Publications

Books

Articles

2023

• Bamgbose G, Tulin AV. 2023. PARP-1 is a transcriptional rheostat of metabolic and bivalent genes during development. Life Science Alliance, in press.
• Bordet G, Bamgbose G, Tulin AV. 2023. Poly(ADP-ribosyl)ating enzymes coordinate changes in the expression of metabolic genes with developmental progression. Scientific Reports, 13: 20320. doi.org/10.1038/s41598-023-47691-8.
• Bamgbose G, Johnson SJ, Tulin AV. 2023. Cooperative targeting of PARP-1 domains to regulate metabolic and developmental genes. Frontiers in Endocrinology. 14:1152570.
• Bhuiyan S, Bordet G, Bamgbose G, Tulin AV. 2023. The Drosophila gene encoding JIG protein (CG14850) is required to modulate nuclear-mitochondrial processes during development. Nucleic Acids Res. 51(11):5647-5660.

2022

• Bordet G, Karpova Y, Tulin AV. 2022. Poly(ADP-ribosyl)ating enzymes cooperate to coordinate development. Scientific Reports. 12(1):22120.
• Karpova Y, Johnson SJ, Bordet G, Guo D, Ghatak A, Markov DA, Tulin AV. 2022. Upregulation of PARG in prostate cancer cells suppresses their malignant behavior and downregulates tumor-promoting genes. Biomedicine & Pharmacotherapy, 153, 113504.
• Johnson SJ, Karpova Y, Guo D, Ghatak A, Markov DA, Tulin AV. 2022. PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment. BMC Cancer, 22(1):557.
• Karpova Y, Guo D, Tulin AV. 2023. Cell-Based Screening for New PARP Inhibitors Utilizing PARG-Mutated Mouse Embryonic Stem Cells. Methods Mol Biol. 2609:375-385.
• Karpova Y, Tulin AV. 2023. TaqMan Multiplex qPCR Method to Genotype PARG Knockout Mice. Methods Mol Biol. 2609:363-371.
• Karpova Y, Tulin AV. 2023. Generating PARP Knockout D.melanogaster with CRISPR/Cas9 System. Methods Mol Biol. 2609:353-362.
• Bordet G, Tulin AV. 2023. Using Drosophila Genetics to Identify Factors that Affect PARP1 Activity In Vivo. Methods Mol Biol. 2609:339-352.
• Bordet G, Bamgbose G, Bhuiyam SH, Johnson S, Tulin AV. 2023. Chromatin Immunoprecipitation Approach to Determine How PARP1 Domains Affect Binding Pattern to Chromatin. Methods Mol Biol. 2609:297-313.

2021

• Bordet G, Kotova E, Tulin AV. 2021. Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity control. Life Science Alliance, 5(3): e202101071.
• Bordet G, Lodhi N, Kossenkov A, Tulin AV. 2021. Age-related changes of gene expression profiles in Drosophila. Genes, 12, 1982.
• Karpova Y, Guo D, Haines AM, Makhov P, Markov DA, Kolenko V, Tulin AV. 2021. Poly(ADP-ribosyl)ation inhibition: a promising approach for ccRCC therapy. Cancers, 13(19): 4973.

2020

• Bordet G, Lodhi N, Guo D, Kossenkov A, Tulin AV. 2020. Poly(ADP-ribose) Polymerase 1 in genome-wide expression control in Drosophila. Scientific Reports. Dec 3;10(1):21151.
• Divan A, Sibi MP, Tulin A. 2020. Structurally unique PARP-1 inhibitors for the treatment of prostate cancer. Pharmacol Res Perspect. 8(2):e00586.
• Makhov P, Uzzo RG, Tulin A*, Kolenko V*. 2020. Histone-dependent PARP-1 inhibitors: a novel therapeutic modality for the treatment of prostate and renal cancers. Urologic Oncology: Seminars and Original Investigations. 8:S1078-1439(20)30145-9. *Co-corresponding authors.
• Hewlett E, Toma M; Sullivan-Reed K; Gordon J; Sliwinski T; Divan A; Tulin A; Childers W; Skorski T. 2020. Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia. Med Chem Res 29(6):962-978.

2019

• Thomas C, Ji Y, Wu C, Datz H, Boyle C, MacLeod B, Patel S, Ampofo M, Currie M, Harbin J, Pechenkina K, Lodhi N, Johnson S, Tulin AV. 2019. Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes. Proc. Natl. Acad. Sci. U. S. A. 116(20): 9941-9946. PNAS
• Karpova Y, Wu C, Divan A, McDonnel ME, Hewlett E, Makhov P, Gordon J, Ye M, Childers WE, Skorski T, Kolenko V, Tulin AV. 2019. Non-NAD-like PARP-1 inhibitors in prostate cancer treatment. Biochemical Pharmacology pii: S0006-2952(19): 30107-8. PubMed

2018

• Nieborowska-Skorska M, Maifrede S, Ye M, Toma M, Hewlett E, Gordon J, Le B-V, Sliwinski T, Zhao H, Piwocka K, Valent P, Tulin A, Childers W, Skorski T. 2018. Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia. Leukemia and Lymphoma 1-4. PubMed

2017

• Thomas C, Kotova E, andTulin AV(2017) PARP-1 Interaction with and Activation by Histones and Nucleosomes. Methods Mol Biol. 1608:255-267.PubMed
• Kotova E and Tulin AV (2017) High-Throughput Colorimetric Assay for Identifying PARP-1 Inhibitors Using a Large Small-Molecule Collection. Methods Mol Biol.1608: 299-312. PubMed
• Naito S, Makhov P, Astsaturov I, Golovine K, Tulin A, Kutikov A, Uzzo RG, and Kolenko VM (2017) LDL cholesterol counteracts the antitumour effect of tyrosine kinase inhibitors against renal cell carcinoma. Br J Cancer. 116(9): 1203-1207. PubMed

2016

• Thomas C, Ji Y, Kotova E, Lodhi N, Pinnola AD, Golovine K, Makhov P, Pechenkina K, Kolenko V,Tulin AV(2016) New generation non-NAD-like PARP-1 inhibitors effectively eliminate drug resistant tumors in vivo. EBioMedicine.13 (2016) 90–98. ScienceDirect
• Ji Y, Thomas C, Tulin N, Lodhi N, Boamah E, Kolenko V, and Tulin AV (2016) Charon mediates IMD-driven PARP-1 dependent immune responses in Drosophila. Journal of Immunology.197: 2382-2389.PMC
• Ji Y andTulin AV(2016) Poly(ADP-ribosyl)ation of hnRNP A1 protein controls translational repression in Drosophila. Molecular and Cellular Biology. 36(19): 2476-2486. PMC
• Lodhi N, Ji. Y andTulin AV (2016) Mitotic bookmarking: maintaining post-mitotic reprogramming of transcription reactivation. Curr Mol Biol Rep. 2: 10-16. SpringerLink

2015

• Golovine K, Makhov P, Naito S, Raiyani H, Tomaszewski J, Mehrazin R, Tulin A, Kutikov A, Uzzo RG, and Kolenko VM (2015) Piperlongumine and its analogs down-regulate expression of c-Met in renal cell carcinoma. Cancer Biol Ther. 16(5): 743-9. PubMed

2014

• Lodhi N, Kossenkov A, and Tulin AV (2014) Bookmarking promoters in mitotic chromatin: Poly(ADP-ribose)Polymerase-1 as an epigenetic mark. Nucleic Acids Res. 42(11): 7028-7038. PubMed
• Kirsanov KI, Kotova E, Markov P, Golovine K, Lesovaya EA, Kolenko V, Yakubovskaya MG, and Tulin AV(2014) Minor grove binding ligands disrupt PARP-1 activation pathways. Oncotarget. 5: 428-437. PMC
• Thomas CJ, Kotova E, Andrake M, Adolf-Bryfogle J, Glaser R, Regnard C, and Tulin AV (2014) Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly-ADP-ribosylation. Mol Cell. 53: 831–842. PubMed
• Makhov P, Golovine K, Teper E, Kutikov A, Mehrazin R, Corcoran A, Tulin A, Uzzo RG, and Kolenko VM (2014) Piperlongumine promotes autophagy via inhibition of Akt/mTOR signaling and mediates cancer cell death. British journal of cancer. 110(4): 899-907.PMC

2013

• Ji Y andTulin AV(2013) Post-transcriptional regulation by Poly(ADP-ribosyl)ation. Int J Mol Sci. 14: 16168-16183. PMC
• Ji Y and Tulin AV(2013) Alternative Splicing Regulation by Poly(ADP-ribosyl)ation. Nova Science Publishers. New Development in Alternative Splicing Research. pp. 159-170.
• Ji Y, Jarnik M, and Tulin AV (2013) Poly(ADP-ribose) Glycohydrolase and Poly(ADP-ribose)-interacting Protein Hrp38 Regulate Pattern Formation during Drosophila Eye Development. Gene. 526: 187–194. PubMed
• Thomas C and Tulin AV (2013) Poly-ADP-Ribose Polymerase: Machinery for Nuclear Processes. Mol Aspects Med. 34(6): 1124-1137. PubMed

2012

• Ji Y and Tulin AV(2012) Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization. Nat Communications. 3: 760. doi:10.1038/ncomms1759. PubMed
• Boamah EK, Kotova E, Garabedian M, Jarnik M, and Tulin AV(2012) Poly(ADP-ribose) Polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli. PLoS Genetics. 8(1):e1002442. PubMed

2011

• Tulin A(2011) Re-evaluating PARP1 inhibitor in cancer. Nat Biotechnol. 2011;29(12):1078-9. Nature Biotechnology
• Garabedian M, Jarnik M, Kotova E, and Tulin AV (2011) Generating a knockdown transgene against Drosophila heterochromatic Tim17b gene encoding mitochondrial translocase subunit. PLoS One. 2011;6(10):e25945. PubMed
• Lohdi N and Tulin AV (2011) PARP1 Genomics: Chromatin Immunoprecipitation Approach using Anti-PARP1 Antibody (ChIP and ChIP-seq). Methods Mol Biol. 780: 191-208. PubMed
• Kotova E, Pinnola AD, and Tulin AV (2011) Small-molecule Collection and High-throughput Colorimetric Assay to Identify PARP-1 Inhibitors. Methods Mol Biol. 780: 491-516. PubMed
• Kotova E, Lodhi N, Jarnik M, Pinnola AD, Ji Y, and Tulin AV(2011) Drosophila histone H2A variant (H2Av) controls Poly(ADP-Ribose) Polymerase 1 (PARP1) activation in chromatin. Proc. Natl. Acad. Sci. USA. 2011;108(15): 6205-6210. PubMed

2010

• Zaret KS, Caravaca JM, Tulin A, Sekiya T (2010) Nuclear Mobility and Mitotic Chromosome Binding: Similarities between Pioneer Transcription Factor FoxA and Linker Histone H1. Cold Spring Harb Symp Quant Biol. 2010;75:219-26. PubMed
• Tikhmyanova N, Tulin AV, Roegiers F, and Golemis EA (2011) Dcas Supports Cell Polarization and Cell-Cell Adhesion Complexes in Development. PLoS One. 2010 Aug 24;5(8). pii: e12369. PubMed
• Ji Y and Tulin AV (2010) The roles of PARP1 in gene control and cell differentiation. Review for Curr. Opin. Genet. Dev. 20(5):512-518. PubMed
• Kotova E, Jarnik M, Tulin AV (2010) Uncoupling of the trans-activation and trans-repression functions of PARP1 protein. Proc Natl Acad Sci USA. 2010;107(14):6406-11. PubMed

2009

• Ji Y and Tulin AV (2009) Poly(ADP-ribosyl)ation of Heterogeneous Nuclear Ribonucleoproteins Modulates Splicing. Nucl. Acids Research. 2009;37:3501-13. PubMed
• Sekiya T, Muthurajan UM, Luger K,Tulin AV, and Zaret KS (2009) Nucleosome-Binding Affinity as a Primary Determinant of the Nuclear Mobility of the Pioneer Transcription Factor FoxA. Genes Dev. 2009;23:804-809. PubMed
• Kotova E, Jarnik M, and Tulin AV(2009) Poly (ADP-ribose) Polymerase 1 is required for protein localization to Cajal body. PLoS Genetics. 2009;5(2):e1000387. PubMed

2000-2008

• Sala A, La Rocca D, Burgio G, Kotova E, Di Gesù D, Collesano M, Ingrassia A, Tulin AV, and Corona DFV (2008) The Nucleosome Remodeling ATPase ISWI is Regulated by poly-ADP-ribosylation. PLoS Biology. 2008;6(10):e252. PubMed
• Pinnola AD, Naumova N, Shah M, and Tulin AV(2007) Nucleosomal core histones mediate dynamic regulation of PARP1 protein binding to chromatin and induction of PARP1 enzymatic activity. J Biol Chem. 2007;282:325119. PubMed
• Tulin A, Naumova N, Menon A, and Spradling A (2006) The Drosophila Poly(ADP-ribose) Glycohydrolase (Parg) protein mediates chromatin structure and Sir2-dependent silencing. Genetics. 2006;172:363-371. Genetics
• Tulin A, Chinenov Y, and Spradling A (2003) Regulation of chromatin structure and gene activity by Poly(ADP-ribose) polymerases. Curr Top Devel Biol. 2003;56:55-83. John Hopkins University
• Kogan GL, Tulin AV, Aravin AA, Abramov YA, Kalmykova AI, Maisonhaute C, and Gvozdev VA (2003) The GATE retrotransposon in Drosophila melanogaster: mobility in heterochromatin and aspects of its expression in germline tissues. Mol Genet Genomics. 2003;269(2):234-42. PubMed
• Tulin A and Spradling A (2003) Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science. 2003;299(5606):560-2. PubMed
• Tulin A, Stewart D, and Spradling AC (2002) The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development. Genes Dev. 2002;16(16): 2108-19. PubMed
• Gvozdev VA, Aravin AA, Abramov YA, Klenov M.S., Kogan GL, Lavrov SA, Naumova NM, Olenkina OM, Tulin AV, and Vagin VV (2003) Stellate repeats: targets of silencing and modules causing cis-inactivation and trans-activation. Genetika. 2003;117(2-3):239-45. PubMed
• Aravin AA, Naumova NM, Tulin AV, Vagin VV, Rozovsky YM, Gvozdev VA (2001) Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline. Curr Biol. 2001;11(13):1017-27. PubMed
• Gvozdev VA, Kogan GL, Tulin AV, Aravin AA, Naumova NM, and Shevelyov YY (2000) Paralogous stellate and Su(Ste) repeats: evolution and ability to silence a reporter gene. Genetika. 2000;109(1-2):131-40. PubMed
• Aravin AA, Naumova NM, Tulin AV, Klenov M.S., Gvozdev VA (2000) The study of interaction between paralogous tandem repeats stellate and suppressor of stellate in the genome of Drosophila melanogaster. Genetika. 2000;36(4):581-4. PubMed

1997-1999

• Erist LK, Kosorukov VS, Antipova TA, Chupina IuM,Tulin AV, Lavrov SA, Bashkirov VN, Gvozdev VA, Brem G, and Korochkin LI (1999) Preparation of transgenic house flies Musca domestica. Dokl Akad Nauk. 1999;367(3):430-2.
• Tulin AV, Naumova NM, Aravin AA, and Gvozdev VA (1998) Repeated, protein-encoding heterochromatic genes cause inactivation of a juxtaposed euchromatic gene. FEBS Lett. 1998;425(3):513-6. ScienceDirect
• Benevolenskaya EV, Kogan GL, Tulin AV, Philipp D, and Gvozdev VA (1997) Segmented gene conversion as a mechanism of correction of 18S rRNA pseudogene located outside of rDNA cluster in D. melanogaster. J Mol Evol. 1997;44(6):646-51. PubMed
• Tulin AV, Kogan GL, Filipp D, Balakireva MD, and Gvozdev VA (1997) Heterochromatic Stellate gene cluster in Drosophila melanogaster: structure and molecular evolution. Genetics. 1997;146(1):253-62. PubMed