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Images

PARP-1 protein localization in Salivary gland polytene chromosomes

The PARP-1 protein localization in salivary gland polytene chromosomes. PARP-1-DsRED and PARPe-EGFP expression in Drosophila larvae. 

Poly(ADP-ribose) turnover

 Poly(ADP-ribose) turnover

PARP-1 mutation

 PARP-1 mutation drastically alters the chromatin structure

Drosophilia development

 PARP-1 mutation causes arrest in Drosophila development

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 PARP-1 activity is restricted to nucleolus and puffs

Localization of PARP-1 and PARG proteins

 Localization of PARP-1 and PARG proteins in a single nucleus

Activity cycle

 PARP protein activity cycle

Cajal Body

 PARP protein localizes into Cajal body in Parg mutants

Cajal body model

 A model of proteins delivery of Cajal body by PARP-1 protein shuttling

Protein localization

 PARP-1 controls hnRNP protein localization in chromatin

Colocalization in puffs

 Colocalization of pADPr and hnRNP proteins in puffs

Poly(ADP-ribosyl)ation inhibitation

 Poly(ADP-ribosyl)ation inhibits hnRNP binding to RNA

Splicing

 The model for the splicing modulation by hnRNP poly(ADP-ribosyl)ation

Nucleolar function

 PARP is required for nucleolar function

Salivary gland

 The PARP protein localization in salivary gland polytene chromosomes

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