Images

The PARP-1 protein localization in salivary gland polytene chromosomes. PARP-1-DsRED and PARPe-EGFP expression in Drosophila larvae.

Poly(ADP-ribose) turnover

PARP-1 mutation drastically alters the chromatin structure

PARP-1 mutation causes arrest in Drosophila development

PARP-1 activity is restricted to nucleolus and puffs

Localization of PARP-1 and PARG proteins in a single nucleus

PARP protein activity cycle

PARP protein localizes into Cajal body in Parg mutants

A model of proteins delivery of Cajal body by PARP-1 protein shuttling

PARP-1 controls hnRNP protein localization in chromatin

Colocalization of pADPr and hnRNP proteins in puffs

Poly(ADP-ribosyl)ation inhibits hnRNP binding to RNA

The model for the splicing modulation by hnRNP poly(ADP-ribosyl)ation

PARP is required for nucleolar function

The PARP protein localization in salivary gland polytene chromosomes