Publications

2019

Weiss K, Lazar HP, Kurolap A, Martinez AF, Paperna T, Cohen L, Smeland MF, Wallen S, Solveig H, Keren B, Terhal P, Irving M, Takaku M,…, Lachlan K. (2019) The CHD4-related syndrome: a comprehensive investigation of the clinical spectrum, genotype-phenotype correlations, and molecular basis. Genet Med
Grimm SA, Shimbo T, Takaku M, Thomas JW, Auerbach S, Bennett B, Bucher JR, Burkholder AB, Day F, Du Y, French JE, Li J, Merrick BA. Tice RR, Wang T, Xu X, Bushel P, Fargo DC, Mullikin JC, Wade PA. (2019) DNA methylation in mice is influenced by genetics as well as sex and life experience. Nat Commun, 10(1). Nature

2018

Blok LS, Rousseau J, Twist J, Ehresmann S, Takaku M, et al. (2018) CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language. Nat Commun, 9 (4619). Nature
Takaku M, Grimm SA, Roberts JD, Chrysovergis K, Bennett BD, Myers P, Perera L, Tucker CJ, Perou CM, and Wade PA. (2018) GATA3 Zinc Finger 2 mutations reprogram the breast cancer transcriptional network. Nat Commun, 9 (1) doi:10.1038/s41467-018-03478-4. Nature

2017

Li P, Wang L, Bennett BD, Wang J, Li J, Qin Y, Takaku M, Wade PA, Wong J, Hu G (2017) Rif1 Promotes a Repressive Chromatin State to Safeguard Against Endogenous Retrovirus Activation. Nucleic Acids Res, 45(22):12723-12738. PubMed
Zhang S, Takaku M, Zou L, Gu A, Chou W, Zhang G, Wu B, Kong Q, Thomas SY, Serody JS, Chen X, Xu X, Wade PA, Cook DN, Ting JP, Wan YY (2017) Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation. Nature, 551(7678):105-109. PubMed
Thomas SY, Whitehead GS, Takaku M, Ward JM, Xu X, Nakano K, Lyons-Cohen MR, Nakano H, Gowdy KM, Wade PA, Cook DN (2017) MyD88-dependent Dendritic and Epithelial Cell Crosstalk Orchestrates Immune Responses to Allergens. Mucosal Immunol, doi: 10.1038/mi.2017.84. Nature

2016

Kobayashi W, Takaku M, Machida S, Tachiwana H, Maehara K, Ohkawa Y, Kurumizaka H (2016) Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing. Sci Rep, 6:24228. PubMed
Shimbo T, Takaku M, Wade PA (2016) High-quality ChIP-seq analysis of MBD3 in human breast cancer cells. Genom Data, 7:173-4. PubMed
Takaku M, Grimm SA, Shimbo T, Perera L, Menafra R, Stunnenberg HG, Archer TK, Machida S, Kurumizaka H, Wade PA (2016) GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler. Genome Biol, 17(1):36. PubMed
Machida M, Hayashida R, Takaku M, Fukuto A, Sun J, Kinomura A, Tashiro S, Kurumizaka H (2016) Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T. Biochemistry, 55(4):637-46. PubMed

2015

Takaku M, Grimm SA, Wade PA. (2015) GATA3 in Breast Cancer: Tumor Suppressor or Oncogene? Gene Expr, 16(4). PubMed

2014

Machida S*, Takaku M*, Ikura M, Sun J, Suzuki H, Kobayashi W, Kinomura A, Osakabe A, Tachiwana H, Horikoshi Y, Fukuto A, Matsuda R, Ura K, Tashiro S, Ikura T, Kurumizaka H. (2014) *co-first authors. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1. Sci Rep, 4:4863. Nature
Adomas AB, Grimm SA, Malone C, Takaku M, Sims JK, Wade PA. (2014) Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer, 14:278. PubMed

2011-2013

Osakabe A, Tachiwana H, Takaku M, Hori T, Obuse C, Kimura H, Fukagawa T, Kurumizaka H. (2013) Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription. J Cell Sci, 126(Pt 6):1323-1332. PubMed
Morozumi Y, Ino R, Takaku M, Hosokawa M, Chuma S, Kurumizaka H. (2012) Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing. Nucleic Acids Res, 40(7):3031-3041. PubMed
Takaku M*, Tsujita T*, Horikoshi N, Takizawa Y, Qing Y, Hirota K, Ikura M, Ikura T, Takeda S, Kurumizaka H. (2011) *co-first authors. Purification of the human SMN-GEMIN2 complex and assessment of its stimulation of RAD51-mediated DNA recombination reactions. Biochemistry, 50(32):6797-6805. Biochemistry
Takaku M*, Ueno H*, and Kurumizaka H. (2011) *co-first authors. Biochemical analysis of the human Ena/Vasp-family proteins, MENA, VASP, and EVL, in homologous recombination. J Biochem, 149(6):721-729. PubMed
Takaku M*, Kainuma T*, Ishida-Takaku T, Ishigami S, Suzuki H, Tashiro S, van Soest RW, Nakao Y and Kurumizaka H. (2011) *co-first authors. Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51.Genes Cell., 16(4):427-436. PubMed

2009-2010

Takaku M, Takahashi D, Machida S, Ueno H, Hosoya N, Ikawa S, Miyagawa K, Shibata T, Kurumizaka H. (2010) Single-stranded DNA catenation mediated by human EVL and a type I topoisomerase. Nucleic Acids Res, 38(21):7579-7586. PubMed
Takizawa Y, Qing Y, Takaku M, Ishida T, Morozumi Y, Tsujita T, Kogame T, Hirota K, Takahashi M, Shibata T, Kurumizaka H, Takeda S. (2010) GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination. Nucleic Acids Res, 38(15):5059-5074. PubMed
Horikoshi N, Morozumi Y, Takaku M, Takizawa Y, Kurumizaka H. (2010) Holliday junction-binding activity of human SPF45. Genes Cell., 15(4):373-383. PubMed
Takaku M, Machida S, Nakayama S, Takahashi D, Kurumizaka H. (2009) Biochemical analysis of the human EVL domains in homologous recombination. FEBS J, 276(20):5841-5848. PubMed
Morozumi Y, Takizawa Y, Takaku M, Kurumizaka H. (2009) Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities. Nucleic Acids Res, 37(13):4296-4307. PubMed
Katsura M, Tsuruga T, Date O, Yoshihara T, Ishida M, Tomoda Y, Okajima M, Takaku M, Kurumizaka H, Kinomura A, Mishima HK, Miyagawa K. (2009) The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction. Nucleic Acids Res, 37(12):3959-3968. PubMed
Takaku M, Machida S, Hosoya N, Nakayama S, Takizawa Y, Sakane I, Shibata T, Miyagawa K, Kurumizaka H. (2009) Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL. J Biol Chem, 284(21):14326-14336. PubMed