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Publications

2019

  • Weiss K, Lazar HP, Kurolap A, Martinez AF, Paperna T, Cohen L, Smeland MF, Wallen S, Solveig H, Keren B, Terhal P, Irving M, Takaku M,…, Lachlan K. (2019) The CHD4-related syndrome: a comprehensive investigation of the clinical spectrum, genotype-phenotype correlations, and molecular basis. Genet Med 

  • Grimm SA, Shimbo T, Takaku M, Thomas JW, Auerbach S, Bennett B, Bucher JR, Burkholder AB, Day F, Du Y, French JE, Li J, Merrick BA. Tice RR, Wang T, Xu X, Bushel P, Fargo DC, Mullikin JC, Wade PA. (2019) DNA methylation in mice is influenced by genetics as well as sex and life experience. Nat Commun, 10(1). Nature

2018

  • Blok LS, Rousseau J, Twist J, Ehresmann S, Takaku M, et al. (2018) CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language. Nat Commun, 9 (4619). Nature
  • Takaku M, Grimm SA, Roberts JD, Chrysovergis K, Bennett BD, Myers P, Perera L, Tucker CJ, Perou CM, and Wade PA. (2018) GATA3 Zinc Finger 2 mutations reprogram the breast cancer transcriptional network. Nat Commun, 9 (1) doi:10.1038/s41467-018-03478-4. Nature

2017

  • Li P, Wang L, Bennett BD, Wang J, Li J, Qin Y, Takaku M, Wade PA, Wong J, Hu G (2017) Rif1 Promotes a Repressive Chromatin State to Safeguard Against Endogenous Retrovirus Activation. Nucleic Acids Res, 45(22):12723-12738. PubMed
  • Zhang S, Takaku M, Zou L, Gu A, Chou W, Zhang G, Wu B, Kong Q, Thomas SY, Serody JS, Chen X, Xu X, Wade PA, Cook DN, Ting JP, Wan YY (2017) Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation. Nature, 551(7678):105-109. PubMed
  • Thomas SY, Whitehead GS, Takaku M, Ward JM, Xu X, Nakano K, Lyons-Cohen MR, Nakano H, Gowdy KM, Wade PA, Cook DN (2017) MyD88-dependent Dendritic and Epithelial Cell Crosstalk Orchestrates Immune Responses to Allergens. Mucosal Immunol, doi: 10.1038/mi.2017.84. Nature

2016

  • Kobayashi W, Takaku M, Machida S, Tachiwana H, Maehara K, Ohkawa Y, Kurumizaka H (2016) Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing. Sci Rep, 6:24228. PubMed
  • Shimbo T, Takaku M, Wade PA (2016) High-quality ChIP-seq analysis of MBD3 in human breast cancer cells. Genom Data, 7:173-4. PubMed
  • Takaku M, Grimm SA, Shimbo T, Perera L, Menafra R, Stunnenberg HG, Archer TK, Machida S, Kurumizaka H, Wade PA (2016) GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler. Genome Biol, 17(1):36. PubMed 
  • Machida M, Hayashida R, Takaku M, Fukuto A, Sun J, Kinomura A, Tashiro S, Kurumizaka H (2016) Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T. Biochemistry, 55(4):637-46. PubMed

2015

  • Takaku M, Grimm SA, Wade PA. (2015) GATA3 in Breast Cancer: Tumor Suppressor or Oncogene? Gene Expr, 16(4). PubMed

2014

  • Machida S*, Takaku M*, Ikura M, Sun J, Suzuki H, Kobayashi W, Kinomura A, Osakabe A, Tachiwana H, Horikoshi Y, Fukuto A, Matsuda R, Ura K, Tashiro S, Ikura T, Kurumizaka H. (2014) *co-first authors. Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1. Sci Rep, 4:4863.  Nature
  • Adomas AB, Grimm SA, Malone C, Takaku M, Sims JK, Wade PA. (2014) Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer, 14:278. PubMed

2011-2013

  • Osakabe A, Tachiwana H, Takaku M, Hori T, Obuse C, Kimura H, Fukagawa T, Kurumizaka H. (2013) Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription. J Cell Sci, 126(Pt 6):1323-1332. PubMed
  • Morozumi Y, Ino R, Takaku M, Hosokawa M, Chuma S, Kurumizaka H. (2012) Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing. Nucleic Acids Res, 40(7):3031-3041. PubMed
  • Takaku M*, Tsujita T*, Horikoshi N, Takizawa Y, Qing Y, Hirota K, Ikura M, Ikura T, Takeda S, Kurumizaka H. (2011) *co-first authors. Purification of the human SMN-GEMIN2 complex and assessment of its stimulation of RAD51-mediated DNA recombination reactions. Biochemistry, 50(32):6797-6805. Biochemistry
  • Takaku M*, Ueno H*, and Kurumizaka H. (2011) *co-first authors. Biochemical analysis of the human Ena/Vasp-family proteins, MENA, VASP, and EVL, in homologous recombination. J Biochem, 149(6):721-729. PubMed
  • Takaku M*, Kainuma T*, Ishida-Takaku T, Ishigami S, Suzuki H, Tashiro S, van Soest RW, Nakao Y and Kurumizaka H. (2011) *co-first authors. Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51.Genes Cell., 16(4):427-436. PubMed

2009-2010

  • Takaku M, Takahashi D, Machida S, Ueno H, Hosoya N, Ikawa S, Miyagawa K, Shibata T, Kurumizaka H. (2010) Single-stranded DNA catenation mediated by human EVL and a type I topoisomerase. Nucleic Acids Res, 38(21):7579-7586. PubMed 
  • Takizawa Y, Qing Y, Takaku M, Ishida T, Morozumi Y, Tsujita T, Kogame T, Hirota K, Takahashi M, Shibata T, Kurumizaka H, Takeda S. (2010) GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination. Nucleic Acids Res, 38(15):5059-5074. PubMed
  • Horikoshi N, Morozumi Y, Takaku M, Takizawa Y, Kurumizaka H. (2010) Holliday junction-binding activity of human SPF45. Genes Cell., 15(4):373-383. PubMed
  • Takaku M, Machida S, Nakayama S, Takahashi D, Kurumizaka H. (2009) Biochemical analysis of the human EVL domains in homologous recombination. FEBS J, 276(20):5841-5848. PubMed
  • Morozumi Y, Takizawa Y, Takaku M, Kurumizaka H. (2009) Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities. Nucleic Acids Res, 37(13):4296-4307. PubMed
  • Katsura M, Tsuruga T, Date O, Yoshihara T, Ishida M, Tomoda Y, Okajima M, Takaku M, Kurumizaka H, Kinomura A, Mishima HK, Miyagawa K. (2009) The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction. Nucleic Acids Res, 37(12):3959-3968. PubMed
  • Takaku M, Machida S, Hosoya N, Nakayama S, Takizawa Y, Sakane I, Shibata T, Miyagawa K, Kurumizaka H. (2009) Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL. J Biol Chem, 284(21):14326-14336. PubMed
Motoki Takaku
Assistant Professor
Columbia Hall Room 1744
P 701.777.2250
motoki.takaku@UND.edu

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