Publications

2016-2017

Krout D, Pramod AB, Dahal RA, Tomlinson MJ, Sharma B, Foster JD, Zou M-F, Boatang C, Newman AH, Lever JR, Vaughan RA, and Henry LK (2017) Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs. Biochem. Pharmacol. 10.1016/j.bcp.2017.07.015. PubMed
Krout D, Rodriquez M, Brose SA, Golovko MY, Henry LK and Thompson BJ (2017) Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms. ACS Chem Neurosci 8, 1011-1018. PMC
Simmler LD, Anacker AMJ, Levin MH, Vaswani NM, Gresch PJ, Nackenoff AG, Anastasio NC, Stutz, SJ, Cunningham, K A, Wang J, Zhang B, Henry LK, Stewart A, Veenstra-VanderWeele, J. and Blakely, R. D. (2017) Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. Br J Pharmacol. PubMed
Richardson BD, Saha K, Krout D, Cabrera E, Felts B, Henry LK, Swant J, Zou M-F, Newman AH, and Khoshbouei H (2016) Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane. Nat Commun 7:10423. Nature

2014-2015

Kumar V, Yarravarapu N, Lapinsky DJ, Perley D, Felts B, Tomlinson MJ, Vaughan RA, Henry LK, Lever JR, and Newman AH (2015) Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram. J Med Chem. 58, 5609–5619. ACS
Dahal RA, Pramod AB, Sharma B, Krout D, Foster JD, Cha JH, Cao J, Newman AH, Lever JR, Vaughan RA, and Henry LK (2014) Computational and Biochemical Docking of the Irreversible Cocaine Analog RTI 82 Directly Demonstrates Ligand Positioning in the Dopamine Transporter Central Substrate-binding Site. J Biol Chem 289, 29712–29727. PubMed
Bowton E, Saunders C, Reddy IA, Campbell NG, Hamilton PJ, Henry LK, Coon H, Sakrikar D, Veenstra-VanderWeele JM, Blakely RD, Sutcliffe J, Matthies HJG, Erreger K, and Galli A (2014) SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry 4, e464. PubMed
Felts B, Pramod AB, Sandtner W, Burbach N, Bulling S, Sitte HH, and Henry LK (2014) The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transport. J Biol Chem 289, 1825-1840. PubMed

2010-2013

Gaffaney JD, Shetty M, Felts B, Pramod AB, Foster JD, Henry LK, and Vaughan RA (2013) Antagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridge. Neurochem Int 73, 16–26. PubMed
Beckman ML, Pramod AB, Perley D, and Henry LK (2013) Stereoselective inhibition of serotonin transporters by antimalarial compounds. Neurochem Int 73, 98–106. PubMed
Pramod AB, Foster J, Carvelli L, and Henry LK (2013) SLC6 transporters: Structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 34, 197–219. PubMed
Henry LK (corresponding author), Iwamoto H, Field JR, Kaufmann K, Dawson ES, Jacobs MT, Adams C, Felts B, Zdravkovic I, Armstrong V, Combs S, Solis E, Rudnick G, Noskov SY, DeFelice LJ, Meiler J, and Blakely RD (2011) A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport., J Biol Chem. 2011. 286, 30823–30836. PubMed
Thompson BJ, Jessen T, Henry LK, Field JR, Gamble KL, Gresch PJ, Carneiro AM, Horton RE, Chisnell PJ, Belova Y, McMahon DG, Daws LC, and Blakely RD (2011) Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proc Natl Acad Sci USA 108, 3785–3790. PubMed
Field JR, Henry LK, and Blakely RD (2010) Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine. J Biol Chem. 2010. 285, 11270-280. PubMed

2006-2009

Kaufmann KW, Dawson ES, Henry LK, Field JR, Blakely RD, and Meiler J (2009) Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies. Proteins. 2009 74:630-642. PubMed
Henry LK, (corresponding author) and Blakely RD (2008) Distinctions between dopamine transporter antagonists could be just around the bend. Mol Pharmacol. 73:616-8. PubMed
Henry LK, Meiler J, and Blakely RD (2007) Bound to be different: neurotransmitter transporters meet their bacterial cousins. Mol. Interv. 7, 306–309. PubMed
Henry LK, DeFelice LJ and Blakely RD (2006) Getting the message across: A recent transporter structure shows the way. Neuron, 2006 Mar 16;49(6):791-6. ScienceDirect
Henry LK, Field JR, Adkins EM, Parnas ML, Vaughan RA, Zou MF, Newman AH, and Blakely RD (2006) Tyr95 and Ile172 in transmembrane segments I and III of human serotonin transporters interact to establish high-affinity recognition of antidepressants. J Biol Chem.2006 Jan 27;281(4):2012-23. PubMed

2000-2003

Henry LK, Adkins EM, and Blakely RD (2003) Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonate modification of transmembrane domain I. J Biol Chem. 2003, Sep 26;278(39):37052-63. JBC
Naider F, Lee BK, Henry LK, Ding F, Khare BK, and Becker JM (2001) Probing the binding site of a heptahelical peptide pheromone receptor using photoaffinity labelling, site-directed mutagenesis and spectroscopic approaches. Proceedings of the 17th American Peptide Symposium. SpringerLink
Henry LK, Khare S, Son C, Babu VV, Naider F, Becker JM (2002) Identification of a contact region between the tridecapeptide alpha-factor mating pheromone of Saccharomyces cerevisiae and its G protein-coupled receptor by photoaffinity labeling. Biochemistry.2002, May 14;41(19):6128-39. PubMed
Munro CA, Winter K, Buchan A, Henry LK, Becker JM, Bulawa CE, and Gow NA (2001) Chs1 of Candida albicans is an essential chitin synthase required for synthesis of the septum and for cell integrity. Mol Microbiol. 2001, 39, (5) 1414-1426. PubMed
Henry LK, Liu S, Lee BK, Wang SH, Arshava B, Becker JM, and Naider F (2000) Position 13 Analogs of the Tridecapeptide Mating Pheromone from Saccharomyces cerevisiae: Design of an Iodinatable Ligand for Receptor Binding. J. Pept. Res.2000, 56, (1) 24-34. PubMed

1995-1998

Lay J, Henry LK, Koltin Y, Bulawa CE, and Becker JM (1998) Altered expression of selectable marker URA3 in gene-disrupted Candida albicans strains complicates interpretation of virulence studies. Infect. Immun. 1998, 66, 5301-5306. PubMed
Bulawa CE, Miller DW, Henry LK, and Becker JM (1995) Attenuated virulence of chitin-deficient mutants of Candida albicans. Proc. Natl. Acad. Sci.1995, 92, 10570-10574. PubMed
Becker JM, Henry LK, Jiang W, and Koltin Y (1995) Reduced virulence of Candida albicans mutants affected in multidrug resistance. Infect. Immun.1995, 63, 4515-4518. PubMed