Nechaev Lab

Welcome to Nechaev lab!

The lab pursues the mechanisms that enable epigenetic regulation of gene activity. The puzzling problem is how the same genome is properly read in each cell and how malfunctioning of this mechanism can lead to cancer. We believe that a phenomenon of RNA polymerase II pausing has something to do with it.

Updates:

11/2023  Sayantani Ghosh Dastidar et al., manuscript is out at Nature Communications! Congratulations Sayantani as well as all involved in this exciting project!

09/2021 Damien Parrello, et al, review manuscript is out. Congratulations all involved!

02/2020 Sayantani Ghosh Dastidar accepts a postdoctoral position at Oregon Health & Science University in the lab of Dr. Gail Mandel. Congratulations and good luck with your new position!

02/2020 Sayantani Ghosh Dastidar defends her PhD thesis. Congratulations Dr. Ghosh Dastidar!

7/19/2019- Nii Koney-Kwaku defends his Ph.D. thesis. Congratulations Dr. Koney and good luck with your new position as Lecturer at the University of Ghana!

7/2019- Epigenetics CoBRE II grant is renewed for the next 5 years! Congrats to the Epigenetics Group and all involved in the great work they did!

06/2019 - Mariia Vlasenok successfully defends her Master's thesis. The work was done in collaboration with Skoltech Life Sciences Program (Moscow, Russia) under supervision of Konstantin Severinov (Skoltech), Sergei Nechaev (UND Biomedical Sciences) and Yen Lee Loh (UND Physics). Congrats Mariia and good luck with your PhD!

06/2019 - Adam Scheidegger publishes a manuscript in BMC Genomics. Congrats Adam and good luck with your new job!

 03/2018 - Sergei receives a 5-year NSF CAREER grant to study the molecular mechanisms of global transcription regulation at gene promoters.

02/2018 - Damien Parrello joins the lab as a postdoctoral fellow.

09/2017 - Sergei receives a 3-year R21 grant for the development of small RNA-based technology to analyze degraded cancer specimens.

04/2017 - Ann Samarakkody accepts a postdoctoral position at Boston Children's Hospital, Harvard Medical School.

03/21/2017 - Ann Samarakkody defends her Ph.D. thesis. Congratulations Dr. Samarakkody!

02/2017 - Ata Abbas accepts a position of Adjunct Assistant Professor at Cleveland Clinic Lerner College of Medicine, Cleveland, OH

12/2016 - Ann Samarakkody presents permanganate footprinting technique at UC Boulder, Taatjes Lab

Recent publications from the lab

• Dastidar, et al., 2023
• Parrello, et al., 2021
• Scheidegger et al., 2019.
• Schacke M. et al., 2019
• Casselli T. et al., 2017
• Scheidegger and Nechaev, 2016.
• Scheidegger et al., 2015.
• Samarakkody et al., 2015.

*Full list of publications from PubMed.