Publications

2023

• Amanda Haage* and Archana Dhasarathy* Working a second job: cell matrix proteins that moonlight in the nucleus Front Cell Dev Biol. 2023 Apr 24;11:1163553. doi: 10.3389/fcell.2023.1163553. eCollection 2023. https://www.frontiersin.org/articles/10.3389/fcell.2023.1163553/full
• Investigating pioneer factor activity and its coordination with chromatin remodelers using integrated synthetic oligo assay. Hengye Chen; Chao Yan; Archana Dhasarathy; Michael Kladde; Lu Bai STAR Protoc. 2023 Jun 7;4(2):102279. doi: 10.1016/j.xpro.2023.102279. https://www.sciencedirect.com/science/article/pii/S2666166723002460?via%3Dihub

 2022

• Hengye Chen, Hungyo Kharerin, Archana Dhasarathy, Michael Kladde, and Lu Bai. Partitioned Usage of Chromatin Remodelers by Nucleosome-Displacing Factors. 2022. Cell Reports. 40(8):111250, AUGUST 23, 2022. https://doi.org/10.1016/j.celrep.2022.111250
•  Mikhala Cooper, Atrayee Ray, Atrayee Bhattacharya, Archana Dhasarathy, and Motoki Takaku. ATAC-seq Optimization for Cancer Epigenetics Research.J Vis Exp. 2022 Jun 30;(184). https://doi.org/10.3791/64242

2019

• Michelle Schacke, Janani Kumar, Nicholas Colwell, Kole Hermanson, Gustavo Folle, Sergei Nechaev, Archana Dhasarathy*, and Laura Lafon-Hughes*. PARP-1/2 inhibitor Olaparib prevents or (partially) reverts EMT induced by TGF-β in NMuMG cells.  International Journal of Molecular Sciences, Special Issue: Epithelial-Mesenchymal Transition". Int J Mol Sci. 2019 Jan 26;20(3):518. doi: 10.3390/ijms20030518.

2018

• Bhattacharya A, Kumar J, Hermanson K, Sun Y, Qureshi H, Perley D, et al. The calcium channel proteins ORAI3 and STIM1 mediate TGF-beta-induced Snai1 expression. Oncotarget. 2018;9(50):29468-83. doi: 10.18632/oncotarget.25672. PubMed 
• Sun Y, Schaar A, Sukumaran P, Dhasarathy A, Singh BB. TGF-beta-induced epithelial-to-mesenchymal transition in prostate cancer cells is mediated via TRPM7 expression. Molecular carcinogenesis. 2018;57(6):752-61. doi: 10.1002/mc.22797. PubMed 

2017

• Casselli T, Qureshi H, Peterson E, Perley D, Blake E, Jokinen B, Abbas A, Nechaev S, Watt JA, Dhasarathy A, and Brissette CA (2017) MicroRNA and mRNA Transcriptome Profiling in Primary Human Astrocytes Infected with Borrelia burgdorferi PLoS One. 2017 Jan 30;12(1): e0170961. eCollection 2017. PubMed

• Dhasarathy A, Roemmich JN, Claycombe KJ. Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes. Molecular aspects of medicine. 2017;54:37-49. doi: 10.1016/j.mam.2016.10.003. PubMed 

• Ye Y, Lin P, Zhang W, Tan S, Zhou X, Li R, et al. DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia. Journal of immunology. 2017;198(7):2844-53. doi: 10.4049/jimmunol.1601001. PubMed 

2016

• Dhasarathy A, Roemmich JN, and Claycombe KJ (2016) Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes. Mol Aspects Med. 2017 Apr; 54:37-49. Epub 2016 Nov 4. PubMed
• Schaar A, Sukumaran P, Sun Y, Dhasarathy A, and Singh BB (2016) TRPC1-STIM1 activation modulates transforming growth factor β-induced epithelial-to-mesenchymal transition. Oncotarget. 2016 Dec 6; 7(49): 80554-80567. PubMed
• Warns JA, Davie JR, and Dhasarathy A (2016) Connecting the dots: chromatin and alternative splicing in EMT. Biochem Cell Biol. 2016 Feb; 94 (1): 12-25. Epub 2015 Jul 7. PubMed

2015

• Zarns K, Desell T, Nechaev S, and Dhasarathy A (2015) Searching the Human Genome for Snail and Slug With DNA@Home.  Proc IEEE Int Conf Escience. 2015 Aug-Sep;2015:429-438. PubMed
• Raza S, Ohm JE, Dhasarathy A, Schommer J, Roche C, Hammer KD, and Ghribi O (2015)  The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. Mol Cell Biochem. 2015 Dec;410(1-2):187-95. Epub 2015 Sep. PubMed
• Ye Y, Tan S, Zhou X, Li X, Jundt MC, Lichter N, Hidebrand A, Dhasarathy A, and Wu MJ (2015) Inhibition of p-IκBα Ubiquitylation by Autophagy-Related Gene 7 to Regulate Inflammatory Responses to Bacterial Infection. Infect Dis. 2015 Dec 1;212(11):1816-26. Epub 2015 May 28. PubMed
• Samarakkody A, Abbas A, Scheidegger A, Warns J, Nnoli O, Jokinen B, Zarns K, Kubat B, Dhasarathy A, and Nechaev S (2015) RNA polymerase II pausing can be retained or acquired during activation of genes involved in the epithelial to mesenchymal transition Nucleic Acids. Res. 2015 Apr 30;43(8):3938-49. Epub 2015 Mar 27. PubMed
• McCowan TJ, Dhasarathy A, and Carvelli LJ (2015) The Epigenetic Mechanisms of Amphetamine Addict. Prev. 2015;2015(Suppl 1). Epub 2015 Feb 9. PubMed

2003-2013

• Dhasarathy A, Shimbo T, Du Y, Grimm SA, Mav D, Shah RR, Shi H, and Wade PA (2013) MBD3 localizes at promoters, gene bodies and enhancers of active genes. PLoS Genet. 2013;9(12):e1004028. Epub 2013 Dec 26. PubMed
• Dhasarathy A, Phadke D, Mav D, Shah RR, and Wade PA (2011) The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PLoS One. 2011;6(10):e26514. Epub 2011 Oct 20. PubMed
• Lai AY, Fatemi M, Dhasarathy A, Malone C, Sobol SE, Geigerman C, Jaye DL, Mav D, Shah R, Li L, and Wade PA (2010) DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exp Med . 2010 Aug 30;207(9):1939-50. Epub 2010 Aug 23. PubMed
• Pondugula S, Neef DW, Voth WP, Darst RP, Dhasarathy A, Reynolds MM, Takahata S, Stillman DJ, and Kladde MP (2009) Coupling phosphate homeostasis to cell cycle-specific transcription: mitotic activation of Saccharomyces cerevisiae PHO5 by Mcm1 and Forkhead proteins. Mol Cell Biol. 2009 Sep;29(18):4891-905. Epub 2009 Jul 13. PubMed
• Dhasarathy A and Wade PA (2008) The MBD protein family-reading an epigenetic mark? Mutat Res. 2008 Dec 1;647(1-2):39-43. Epub 2008 Jul 22. PubMed
• Dhasarathy A, Kajita M, and Wade PA (2007) The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha. Mol Endocrinol. 2007 Dec;21(12):2907-18 Epub 2007 Aug 30. PubMed
• Dhasarathy A and Kladde MP (2006) Promoter occupancy is a major determinant of chromatin remodeling enzyme requirements. Mol Cell Biol. 2005 Apr;25(7):2698-707 Erratum in: Mol Cell Biol. 2006 Jan;26(1):388. PubMed
• Norwood LE, Grade SK, Cryderman DE, Hines KA, Furiasse N, Toro R, Li Y, Dhasarathy A, Kladde MP, Hendrix MJ, Kirschmann DA, and Wallrath Gene LL (2004) Conserved properties of HP1(Hsalpha). 2004 Jul 7;336(1):37-46. PubMed
• Jessen WJ, Dhasarathy A, Hoose SA, Carvin CD, Risinger AL, and Kladde MP (2004) Mapping chromatin structure in vivo using DNA methyltransferases. Methods. 2004 May;33(1):68-80. PubMed
• Carvin CD, Dhasarathy A, Friesenhahn LB, Jessen WJ, and Kladde MP (2003) Targeted cytosine methylation for in vivo detection of protein-DNA interactions. Proc Natl Acad Sci U S A . 2003 Jun 24;100(13):7743-8. Epub 2003 Jun 13. PubMed

*Co-corresponding author