Welcome to the Archana Dhasarathy laboratory!
Gene Regulation during EMT
The Epithelial to Mesenchymal Transition involves changes in cellular phenotype from a well-differentiated, immobile state to a non-adhesive, mobile phenotype. This transition is involved in early development, when cells migrate to form different germ layers and hence tissues, to cancer metastasis, when cells move from the original tumor site to other locations in the body. Our lab aims to understand the molecular basis for this transition, specifically addressing 3 important questions:
(1) What are the signals that induce EMT?
(2) How are EMT-related transcription factors such as SNAIL-regulated?
(3) What roles do transcription factor proteins play during EMT?