Epigenomics of Development and Disease

Researchers studying epigenetics and epigenomics explore the mechanisms that regulate gene expression.

The Epigenetics Working Group unites multiple research teams using different conceptual frameworks and experimental approaches to study epigenetic mechanisms regulating development and aging. Using a wide range of experimental systems, research teams are aiming to uncover how exposure to developmental and environmental stress leads to the accumulation of genome-wide epigenetic changes and whether these changes can eventually cause or exacerbate development of aging-associated diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases.

As a group, we are targeting molecular mechanisms of local and reversible genome-wide reprogramming, cellular heritability of epigenetic changes, fine-tuning of local gene activity that can be recruited for clinical applications. Understanding how chromatin proteins act during normal development and during pathogenesis to shape the chromatin landscape will allow us to develop methods to experimentally re-program genes and gene networks and to design new therapeutic regimens for treating human disorders.

Faculty

brissette
Associate Professor, Department of Biomedical Sciences
Holly Brown-Borg
Chester Fritz Distinguished Professor, Department of Biomedical Sciences
Kate Larson
Acting Research Leader, Agricultural Research Service Human Nutrition Research Center
Diane Darland
Associate Professor, Department of Biology
Tristian Darland
Assistant Professor, Department of Biology
  • 701.777.3375
  • Starcher Hall Room 309
    10 Cornell St Stop 9019
    Grand Forks, ND 58202-9019 

     

Archana Dhasarathy
Assistant Professor, Department of Biomedical Sciences
Keith Henry
Associate Professor, Department of Biomedical Sciences Adjunct Professor, Department of Chemistry
Manu
Assistant Professor, Department of Biology
Barry Milavetz
Professor, Department of Biomedical Sciences
Kumi
Assistant Professor, Department of Pathology
Sergei Nechaev
Associate Professor, Department of Biomedical Sciences
Alexei Tulin
Professor, Department of Biomedical Sciences 
Roxanne Vaughan
Professor, Department of Biomedical Sciences
John Watt
Associate Professor, Department of Biomedical Sciences
  • 701.777.6225
  • Neuroscience Building
    504 Hamline St Stop 9061
    Grand Forks, ND 58203-9061

    504 Nth Hameline St, Office room 124, Lab room 126

    Watt lab page