News and Publications

 

2023 Publications

Chen KS, Noureldein MH, McGinley LM, Hayes JM, Rigan DM, Kwentus JF, Mason SN, Mendelson FE, Savelieff MG, Feldman EL. Human neural stem cells restore spatial memory in a transgenic Alzheimer's disease mouse model by an immunomodulating mechanism. Front Aging Neurosci. 2023 Dec 14;15:1306004. doi: 10.3389/fnagi.2023.1306004. PMID: 38155736

Wilbourne J, Jia S, Fogarty A, Takaku M, Zhao F. Crucial Roles of the Mesenchymal Androgen Receptor in Wolffian Duct Development. Endocrinology. 2023 Dec 23;165(2):bqad193. doi: 10.1210/endocr/bqad193. PMID: 38146640

Karpova Y, Orlicky DJ, Schmidt EE, Tulin AV. Disrupting Poly(ADP-ribosyl)ating Pathway Creates Premalignant Conditions in Mammalian Liver. Int J Mol Sci. 2023 Dec 6;24(24):17205. doi: 10.3390/ijms242417205. PMID: 38139034

Basheer A, Jamal SB, Alzahrani B, Faheem M. Development of a tetravalent subunit vaccine against dengue virus through a vaccinomics approach. Front Immunol. 2023 Nov 17;14:1273838. doi: 10.3389/fimmu.2023.1273838. PMID: 38045699

Vomhof-DeKrey EE, Rajpathy OK, Preszler E, Basson MD. Vil-Cre specific Slfn3KO mice exhibit sex-specific differences in lung, stomach, cecum, kidney, and proximal colon differentiation markers and Slfn family members expression levels. Biochem Biophys Rep. 2023 Nov 23;36:101552. doi: 10.1016/j.bbrep.2023.101552. PMID: 38076659

Navaeiseddighi Z, Tripathi JK, Guo K, Wang Z, Schmit T, Brooks DR, Allen RA, Hur J, Mathur R, Jurivich D, Khan N. IL-17RA promotes pathologic epithelial inflammation in a mouse model of upper respiratory influenza infection. PLoS Pathog. 2023 Dec 7;19(12):e1011847. doi: 10.1371/journal.ppat.1011847. PMID: 38060620

Seeger DR, Schofield B, Besch D, Golovko SA, Kotha P, Parmer M, Solaymani-Mohammadi S, Golovko MY. Exogenous oxygen is required for prostanoid induction under brain ischemia as evidence for a novel regulatory mechanism. J Lipid Res. 2023 Nov;64(11):100452. doi: 10.1016/j.jlr.2023.100452. Epub 2023 Sep 30. PMID: 37783389

Brown SR, Vomhof-DeKrey EE, Al-Marsoummi S, Brown ND, Hermanson K, Basson MD. Schlafen Family Intra-Regulation by IFN-α2 in Triple-Negative Breast Cancer. Cancers (Basel). 2023 Nov 30;15(23):5658. doi: 10.3390/cancers15235658. PMID: 38067362

Shetty M, Bolland DE, Morrell J, Grove BD, Foster JD, Vaughan RA. Dopamine transporter membrane mobility is bidirectionally regulated by phosphorylation and palmitoylation. Curr Res Physiol. 2023 Sep 29;6:100106. doi: 10.1016/j.crphys.2023.100106. PMID: 38107792

Khasabova IA, Khasabov SG, Johns M, Juliette J, Zheng A, Morgan H, Flippen A, Allen K, Golovko MY, Golovko SA, Zhang W, Marti J, Cain D, Seybold VS, Simone DA. Exosome-associated lysophosphatidic acid signaling contributes to cancer pain. Pain. 2023 Dec 1;164(12):2684-2695. doi: 10.1097/j.pain.0000000000002967. Epub 2023 Jun 6. PMID: 37278638

Ekanayake EMDV, De Silva PMCS, Gunasekara TDKSC, Thakshila WAKG, Gunarathna SD, Pinipa RAI, Jayasinghe S, Chandana EPS, Wijewickrama ES, Jayasundara N. Prevalence of Chronic Kidney Disease of Uncertain Etiology Within Selected Farming Communities in Rural Sri Lanka. Can J Kidney Health Dis. 2023 Sep 26;10:20543581231199013. doi: 10.1177/20543581231199013. PMID: 37771543

Elzinga SE, Eid SA, McGregor BA, Jang DG, Hinder LM, Dauch JR, Hayes JM, Zhang H, Guo K, Pennathur S, Kretzler M, Brosius FC, Koubek EJ, Feldman EL, Hur J. Transcriptomic analysis of diabetic kidney disease and neuropathy in mouse models of type 1 and type 2 diabetes. Dis Model Mech. 2023 Oct 1;16(10):dmm050080. doi: 10.1242/dmm.050080. Epub 2023 Oct 4. PMID: 37791586

Goutman SA, Savelieff MG, Jang DG, Hur J, Feldman EL. The amyotrophic lateral sclerosis exposome: recent advances and future directions. Nat Rev Neurol. 2023 Oct;19(10):617-634. doi: 10.1038/s41582-023-00867-2. Epub 2023 Sep 14. PMID: 37709948

Nookala S, Mukundan S, Grove B, Combs C. Concurrent Brain Subregion Microgliosis in an HLA-II Mouse Model of Group A Streptococcal Skin Infection. Microorganisms. 2023 Sep 20;11(9):2356. doi: 10.3390/microorganisms11092356. PMID: 37764200

Mayer FP, Stewart A, Varman DR, Moritz AE, Foster JD, Owens AW, Areal LB, Gowrishankar R, Velez M, Wickham K, Phelps H, Katamish R, Rabil M, Jayanthi LD, Vaughan RA, Daws LC, Blakely RD, Ramamoorthy S. Kappa Opioid Receptor Antagonism Rescues Genetic Perturbation of Dopamine Homeostasis: Molecular, Physiological and Behavioral Consequences. bioRxiv [Preprint]. 2023 May 3:2023.05.03.539310. doi: 10.1101/2023.05.03.539310. PMID: 37205452

Tayyebi A, Alshami AS, Rabiei Z, Yu X, Ismail N, Talukder MJ, Power J. Prediction of organic compound aqueous solubility using machine learning: a comparison study of descriptor-based and fingerprints-based models. J Cheminform. 2023 Oct 18;15(1):99. doi: 10.1186/s13321-023-00752-6. PMID: 37853492

Brown CR, Foster JD. Palmitoylation Regulates Human Serotonin Transporter Activity, Trafficking, and Expression and Is Modulated by Escitalopram. ACS Chem Neurosci. 2023 Sep 20;14(18):3431-3443. doi: 10.1021/acschemneuro.3c00319. Epub 2023 Aug 29. PMID: 37644775

Thompson D, Odufuwa AE, Brissette CA, Watt JA. Transcriptome and methylome of the supraoptic nucleus provides insights into the age-dependent loss of neuronal plasticity. Front Aging Neurosci. 2023 Aug 30;15:1223273. doi: 10.3389/fnagi.2023.1223273. PMID: 37711995

Saotome M, Poduval DB, Grimm SA, Nagornyuk A, Gunarathna S, Shimbo T, Wade PA, Takaku M. Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4. Res Sq [Preprint]. 2023 Mar 15:rs.3.rs-2587918. doi: 10.21203/rs.3.rs-2587918/v1. PMID: 36993416

Jusufovic N, Krusenstjerna AC, Savage CR, Saylor TC, Brissette CA, Zückert WR, Schlax PJ, Motaleb MA, Stevenson B. Borrelia burgdorferi PlzA is a cyclic-di-GMP dependent DNA- and RNA-binding protein. bioRxiv [Preprint]. 2023 Sep 5:2023.01.30.526351. doi: 10.1101/2023.01.30.526351. PMID: 36778503

Brissette C, Moniuszko-Malinowska A, Nuttens C, Lindgren PE, Angulo FJ. An Expert Panel Discussion Lyme Disease in Europe. Vector Borne Zoonotic Dis. 2023 Sep;23(S1):i-S8. doi: 10.1089/vbz.2023.29009.bri. PMID: 37755330

Thompson D, Odufuwa AE, Watt JA. Microdissection of the supraoptic nucleus and posterior pituitary gland from fresh unfixed tissue. MethodsX. 2023 Sep 22;11:102388. doi: 10.1016/j.mex.2023.102388. PMID: 37791008

Talukdar SN, McGregor B, Osan JK, Hur J, Mehedi M. RSV infection does not induce EMT. bioRxiv [Preprint]. 2023 Mar 14:2023.03.13.532506. doi: 10.1101/2023.03.13.532506. PMID: 36993657

Combs P, Erickson J, Hsieh JH, Guo K, Nolte S, Schmitt C, Auerbach S, Hur J. Corrigendum: Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis. Front Toxicol. 2023 Aug 24;5:1278066. doi: 10.3389/ftox.2023.1278066. Erratum for: Front Toxicol. 2023 Jun 27;5:1147608. PMID: 37692902

Ke T, Ambigapathy G, Ton T, Dhasarathy A, Carvelli L. Long-Lasting Epigenetic Changes in the Dopamine Transporter in Adult Animals Exposed to Amphetamine during Embryogenesis: Investigating Behavioral Effects. Int J Mol Sci. 2023 Aug 23;24(17):13092. doi: 10.3390/ijms241713092. PMID: 37685899

Elsayed AAR, Newman WP, Klug MG, Basson MD. Effect of COVID-19 and its vaccines on surgical and postsurgical mortality, ICU admission and 90-day readmission for elective surgical procedures in a United States veteran population. Am J Surg. 2023 Sep;226(3):379-384. doi: 10.1016/j.amjsurg.2023.06.017. Epub 2023 Jun 14. PMID: 37357039

Sun D, Wu S, Martin JP, Tayutivutikul K, Du G, Combs C, Darland DC, Zhao JX. Streamlined synthesis of potential dual-emissive fluorescent silicon quantum dots (SiQDs) for cell imaging. RSC Adv. 2023 Sep 4;13(38):26392-26405. doi: 10.1039/d3ra03669c. PMID: 37671347

Eid SA, Rumora AE, Beirowski B, Bennett DL, Hur J, Savelieff MG, Feldman EL. New perspectives in diabetic neuropathy. Neuron. 2023 Sep 6;111(17):2623-2641. doi: 10.1016/j.neuron.2023.05.003. Epub 2023 May 31. PMID: 37263266

Zhang X, Isah MB, Dang M, Morgan PM, Sienczyk M, Bradley D, Chacana P. Editorial: IgY technology: theory, technical aspects, applications, and innovations. Front Immunol. 2023 Aug 18;14:1267926. doi: 10.3389/fimmu.2023.1267926. PMID: 37662904

Ambigapathy G, Mukundan S, Nagamoto-Combs K, Combs CK, Nookala S. HLA-II-Dependent Neuroimmune Changes in Group A Streptococcal Necrotizing Fasciitis. Pathogens. 2023 Jul 31;12(8):1000. doi: 10.3390/pathogens12081000. PMID: 37623960

Jimenez DE, Tahir M, Faheem M, Alves WBDS, Correa BL, Andrade GR, Larsen MR, Oliveira GP Jr, Pereira RW. Comparison of Four Purification Methods on Serum Extracellular Vesicle Recovery, Size Distribution, and Proteomics. Proteomes. 2023 Jul 25;11(3):23. doi: 10.3390/proteomes11030023. PMID: 37606419

Talukdar SN, McGregor B, Osan JK, Hur J, Mehedi M. Respiratory Syncytial Virus Infection Does Not Induce Epithelial-Mesenchymal Transition. J Virol. 2023 Jul 27;97(7):e0039423. doi: 10.1128/jvi.00394-23. Epub 2023 Jun 20. PMID: 37338373

Wrede D, Bordak M, Abraham Y, Mehedi M. Pulmonary Pathogen-Induced Epigenetic Modifications. Epigenomes. 2023 Jul 6;7(3):13. doi: 10.3390/epigenomes7030013. PMID: 37489401

Mehedi M., Ricklefs S., Takada A., Sturdevant D., Marzi A., Porcella S.F., Feldmann H., RNA editing is a general trait of Ebola viruses. Epub ahead of print. JID. Jun 22, 2023. jiad228.

Eid SA, Noureldein M, Kim B, Hinder LM, Mendelson FE, Hayes JM, Hur J, Feldman EL. Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination. J Neurochem. 2023 Jul;166(2):367-388. doi: 10.1111/jnc.15877. Epub 2023 Jun 16. PMID: 37328915.

McGregor BA, Razmjou E, Hooshyar H, Seeger DR, Golovko SA, Golovko MY, Singer SM, Hur J, Solaymani-Mohammadi S. A shotgun metagenomic analysis of the fecal microbiome in humans infected with Giardia duodenalis. Parasit Vectors. 2023 Jul 18;16(1):239. doi: 10.1186/s13071-023-05821-1. PMID: 37464386

Combs P, Erickson J, Hsieh JH, Guo K, Nolte S, Schmitt C, Auerbach S, Hur J. Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis. Front Toxicol. 2023 Jun 27;5:1147608. doi: 10.3389/ftox.2023.1147608. PMID: 37441091

Bamgbose G, Johnson S, Tulin A. Cooperative targeting of PARP-1 domains to regulate metabolic and developmental genes. Front Endocrinol (Lausanne). 2023 Jun 6;14:1152570. doi: 10.3389/fendo.2023.1152570. PMID: 37347109

Boyle CA, Lei S. Neuromedin B excites central lateral amygdala neurons and reduces cardiovascular output and fear-potentiated startle. J Cell Physiol. 2023 Jun;238(6):1381-1404. doi: 10.1002/jcp.31020. Epub 2023 Apr 26. PMID: 37186390.

Gaikwad HK, Jaswandkar SV, Katti KS, Haage A, Katti DR. Molecular basis of conformational changes and mechanics of integrins. Philos Trans A Math Phys Eng Sci. 2023 Jul 10;381(2250):20220243. doi: 10.1098/rsta.2022.0243. Epub 2023 May 22. PMID: 37211038

Villeda S, Brown-Borg H, Anderson R. Neurobiology of Aging: New Insights From Across the Research Spectrum. J Gerontol A Biol Sci Med Sci. 2023 Jun 1;78(6):869-871. doi: 10.1093/gerona/glad110. PMID: 37264524

Li L, Liu W, Zhang H, Cai Q, Wen D, Du J, Sun J, Li L, Gao C, Lin P, Wu M, Jiang J. A New Method for Programmable RNA Editing Using CRISPR Effector Cas13X.1. Tohoku J Exp Med. 2023 May 17;260(1):51-61. doi: 10.1620/tjem.2023.J011. Epub 2023 Feb 23. PMID: 36823185

Haage A, Dhasarathy A. Working a second job: Cell adhesion proteins that moonlight in the nucleus. Front Cell Dev Biol. 2023 Apr 24;11:1163553. doi: 10.3389/fcell.2023.1163553. PMID: 37169022;

Hess RA, Erickson OA, Cole RB, Isaacs JM, Alvarez-Clare S, Arnold J, Augustus-Wallace A, Ayoob JC, Berkowitz A, Branchaw J, Burgio KR, Cannon CH, Ceballos RM, Cohen CS, Coller H, Disney J, Doze VA, Eggers MJ, Ferguson EL, Gray JJ, Greenberg JT, Hoffmann A, Jensen-Ryan D, Kao RM, Keene AC, Kowalko JE, Lopez SA, Mathis C, Minkara M, Murren CJ, Ondrechen MJ, Ordoñez P, Osano A, Padilla-Crespo E, Palchoudhury S, Qin H, Ramírez-Lugo J, Reithel J, Shaw CA, Smith A, Smith RJ, Tsien F, Dolan EL. Virtually the Same? Evaluating the Effectiveness of Remote Undergraduate Research Experiences. CBE Life Sci Educ. 2023 Jun;22(2):ar25. doi: 10.1187/cbe.22-01-0001. PMID: 37058442

Halcrow PW, Kumar N, Hao E, Khan N, Meucci O, Geiger JD. Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death. NeuroImmune Pharm Ther. 2023 Mar 25;2(1):19-35. doi: 10.1515/nipt-2022-0013. Epub 2022 Sep 14. PMID: 37027339

Higgs S, Brissette CA. An Overview of Lyme Disease in Europe. Vector Borne Zoonotic Dis. 2023 Apr;23(4):137-138. doi: 10.1089/vbz.2023.29006.hig. PMID: 37071409

Sun Y, Nascimento Da Conceicao V, Chauhan A, Sukumaran P, Chauhan P, Ambrus JL, Vissink A, Kroese FGM, Muniswamy M, Mishra BB, Singh BB. Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca²⁺ signaling. Clin Transl Med. 2023 Apr;13(4):e1228. doi: 10.1002/ctm2.1228. PMID: 37006181

Saylor TC, Savage CR, Krusenstjerna AC, Jusufovic N, Zückert WR, Brissette CA, Motaleb M, Schlax PJ, Stevenson B. Quantitative analyses of interactions between SpoVG and RNA/DNA. Biochem Biophys Res Commun. 2023 Apr 30;654:40-46. doi: 10.1016/j.bbrc.2023.02.044. Epub 2023 Feb 27. PMID: 36889033.

Hur J, Paez-Colasante X, Figueroa-Romero C, Lo TW, Barmada SJ, Paulsen MT, Ljungman M, Alakwaa FM, Savelieff MG, Goutman SA, Feldman EL. miRNA analysis reveals novel dysregulated pathways in amyotrophic lateral sclerosis. Hum Mol Genet. 2023 Mar 6;32(6):934-947. doi: 10.1093/hmg/ddac250. PMID: 36219176

Guo K, Figueroa-Romero C, Noureldein M, Hinder LM, Sakowski SA, Rumora AE, Petit H, Savelieff MG, Hur J, Feldman EL. Gut microbiota in a mouse model of obesity and peripheral neuropathy associated with plasma and nerve lipidomics and nerve transcriptomics. Microbiome. 2023 Mar 15;11(1):52. doi: 10.1186/s40168-022-01436-3. PMID: 36922895

Datta G, Miller NM, Chen X. 17⍺-Estradiol Protects against HIV-1 Tat-Induced Endolysosome Dysfunction and Dendritic Impairments in Neurons. Cells. 2023 Mar 6;12(5):813. doi: 10.3390/cells12050813. PMID: 36899948

Talukdar SN, Osan J, Ryan K, Grove B, Perley D, Kumar BD, Yang S, Dallman S, Hollingsworth L, Bailey KL, Mehedi M. RSV-induced expanded ciliated cells contribute to bronchial wall thickening. Virus Res. 2023 Apr 2;327:199060. doi: 10.1016/j.virusres.2023.199060. Epub 2023 Feb 14. PMID: 36746339

Henn RE, Guo K, Elzinga SE, Noureldein MH, Mendelson FE, Hayes JM, Rigan DM, Savelieff MG, Hur J, Feldman EL. Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity. iScience. 2023 Feb 8;26(3):106164. doi: 10.1016/j.isci.2023.106164. PMID: 36915697

Xia Z, Zhong W, Wu M, Evans SE. Editorial: The interplay between microbiota and allergen in shaping respiratory mucosa immunity: Role in development of asthma. Front Immunol. 2023 Feb 16;14:1131215. doi: 10.3389/fimmu.2023.1131215. PMID: 36875065

Stevenson B, Brissette CA. Erp and Rev Adhesins of the Lyme Disease Spirochete's Ubiquitous cp32 Prophages Assist the Bacterium during Vertebrate Infection. Infect Immun. 2023 Mar 15;91(3):e0025022. doi: 10.1128/iai.00250-22. Epub 2023 Feb 28. PMID: 36853019

Chen X, Gawryluk JW, Wagener JF, Ghribi O, Geiger JD. Correction: Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J Neuroinflammation. 2023 Feb 18;20(1):40. doi: 10.1186/s12974-023-02725-w. Erratum for: J Neuroinflammation. 2008 Apr 03;5:12. PMID: 36800964

Saylor TC, Savage CR, Krusenstjerna AC, Jusufovic N, Zückert WR, Brissette CA, Motaleb M, Schlax PJ, Stevenson B. Quantitative analyses of interactions between SpoVG and RNA/DNA. bioRxiv [Preprint]. 2023 Feb 6:2023.02.06.527361. doi: 10.1101/2023.02.06.527361. PMID: 36860938

Khasabova IA, Gable J, Johns M, Khasabov SG, Kalyuzhny AE, Golovko MY, Golovko SA, Kiven S, Gupta K, Seybold VS, Simone DA. Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease. Haematologica. 2023 Mar 1;108(3):859-869. doi: 10.3324/haematol.2021.280460. PMID: 35615929

Milavetz B, Hanson B, Rowbotham K, Haugen J. Mapping Nucleosome Location Using FS-Seq. Methods Mol Biol. 2023;2611:21-38. doi: 10.1007/978-1-0716-2899-7_2. PMID: 36807061.

Cleveland DW, Anderson CC, Brissette CA. Borrelia miyamotoi: A Comprehensive Review. Pathogens. 2023 Feb 7;12(2):267. doi: 10.3390/pathogens12020267. PMID: 36839539

Jerome K, Sattar S, Mehedi M. Simultaneous detection and quantification of spike mRNA and protein in SARS-CoV-2 infected airway epithelium. MethodsX. 2023;10:102050. doi: 10.1016/j.mex.2023.102050. Epub 2023 Feb 3. PMID: 36779029

Campbell KS, Keller P, Golovko SA, Seeger D, Golovko MY, Kerby JL. Connecting the Pipes: Agricultural Tile Drains and Elevated Imidacloprid Brain Concentrations in Juvenile Northern Leopard Frogs (Rana pipiens). Environ Sci Technol. 2023 Feb 21;57(7):2758-2767. doi: 10.1021/acs.est.2c06527. Epub 2023 Feb 8. PMID: 36753680

Sattar S, Kabat J, Jerome K, Feldmann F, Bailey K, Mehedi M. Nuclear translocation of spike mRNA and protein is a novel feature of SARS-CoV-2. Front Microbiol. 2023 Jan 26;14:1073789. doi: 10.3389/fmicb.2023.1073789. PMID: 36778849

Singhal SK, Al-Marsoummi S, Vomhof-DeKrey EE, Lauckner B, Beyer T, Basson MD. Schlafen 12 Slows TNBC Tumor Growth, Induces Luminal Markers, and Predicts Favorable Survival. Cancers (Basel). 2023 Jan 7;15(2):402. doi: 10.3390/cancers15020402. PMID: 36672349

Huang H, Even Z, Wang Z, Li L, Erickson A, Golovko M, Golovko S, Darland D, Mathur R, Wang X. Proteomics Profiling Reveals Regulation of Immune Response to Salmonella enterica Serovar Typhimurium Infection in Mice. Infect Immun. 2023 Jan 24;91(1):e0049922. doi: 10.1128/iai.00499-22. Epub 2022 Dec 13. PMID: 36511704

Chittimalli K, Jahan J, Sakamuri A, Weyrick H, Winkle W, Adkins S, Vetter SW, Jarajapu YPR. Reversal of aging-associated increase in myelopoiesis and expression of alarmins by angiotensin-(1-7). Sci Rep. 2023 Feb 13;13(1):2543. doi: 10.1038/s41598-023-29853-w. PMID: 36782016

Han J, Wang J, Shi H, Li Q, Zhang S, Wu H, Li W, Gan L, Brown-Borg HM, Feng W, Chen Y, Zhao RC. Ultra-small polydopamine nanomedicine-enabled antioxidation against senescence. Mater Today Bio. 2023 Jan 21;19:100544. doi: 10.1016/j.mtbio.2023.100544. PMID: 36747580

Sakowski SA, Savelieff MG, Feldman EL. Disrupted axon-glia communication leads to neurodegeneration in metabolic diseases. Neurobiol Dis. 2023 Feb;177:105994. doi: 10.1016/j.nbd.2023.105994. Epub 2023 Jan 9. PMID: 36632920

Haage A, Tanentzapf G. Analysis of Integrin-Dependent Melanoblast Migration During Development. Methods Mol Biol. 2023;2608:207-221. doi: 10.1007/978-1-0716-2887-4_13. PMID: 36653710.

Bordet G, Bamgbose G, Bhuiyam SH, Johnson S, Tulin AV. Chromatin Immunoprecipitation Approach to Determine How PARP1 Domains Affect Binding Pattern to Chromatin. Methods Mol Biol. 2023;2609:297-313. doi: 10.1007/978-1-0716-2891-1_17. PMID: 36515842

Bordet G, Tulin AV. Using Drosophila Genetics to Identify Factors that Affect PARP1 Activity In Vivo. Methods Mol Biol. 2023;2609:339-352. doi: 10.1007/978-1-0716-2891-1_20. PMID: 36515845

Karpova Y, Tulin AV. Generating PARP Knockout D. melanogaster with CRISPR/Cas9 System. Methods Mol Biol. 2023;2609:353-362. doi: 10.1007/978-1-0716-2891-1_21. PMID: 36515846

Karpova Y, Tulin AV. TaqMan Multiplex qPCR Method to Genotype PARG Knockout Mice. Methods Mol Biol. 2023;2609:363-371. doi: 10.1007/978-1-0716-2891-1_22. PMID: 36515847

Karpova Y, Guo D, Tulin AV. Cell-Based Screening for New PARP Inhibitors Utilizing PARG-Mutated Mouse Embryonic Stem Cells. Methods Mol Biol. 2023;2609:375-385. doi: 10.1007/978-1-0716-2891-1_23. PMID: 36515848

2022 Publications

Osan K.J, Talukdar S.N., Fedlamnn F, DeMontigny B.A., Jerome K., Bailey K.L., Feldmann, H., and Mehedi M.Goblet cell hyperplasia increases SARS-CoV-2 infection in Chronic Obstructive Pulmonary Disease. Microbiology Spectrum. 2022. Vol 10. Np. 4. E00459-22.

Mitzel H., Brown D., Thomas M., Curl B., Wild M., Keisch A., Muskrat J., Hossain A., Ryan K., Babalola O., Burgrad M., and Mehedi M. Patient-centered discussion on End-of-life care for patient with advanced COPD. Medicina. 2022. 58 (2): 254.

Halcrow P, Kumar N, Hao E, Khan N, Meucci O, Geiger JD. "Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death" NeuroImmune Pharmacology and Therapeutics, 2022. https://doi.org/10.1515/nipt-2022-0013

Saotome M, Poduval DB, Nair R, Cooper M, Takaku M. GATA3 Truncation Mutants Alter EMT Related Gene Expression via Partial Motif Recognition in Luminal Breast Cancer Cells. Front Genet. 2022 Jan 28;13:820532. doi: 10.3389/fgene.2022.820532. PMID: 35154280; PMCID: PMC8831884.

Ai J, Hong W, Wu M, Wei X. Pulmonary vascular system: A vulnerable target for COVID-19. MedComm (2020). 2021 Oct 17;2(4):531-547. doi: 10.1002/mco2.94. PMID: 34909758

Borkar NA, Combs CK, Sathish V. Sex Steroids Effects on Asthma: A Network Perspective of Immune and Airway Cells. Cells. 2022 Jul 19;11(14):2238. doi: 10.3390/cells11142238. PMID: 35883681

Ward SE, O'Sullivan JM, Moran AB, Spencer DIR, Gardner RA, Sharma J, Fazavana J, Monopoli M, McKinnon TAJ, Chion A, Haberichter S, O'Donnell JS. Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance. Haematologica. 2022 Mar 1;107(3):668-679. doi: 10.3324/haematol.2020.274720. PMID: 33763999

Greenmyer JR, Montgomery M, Hosford C, Burd M, Miller V, Storandt MH, Lakpa KL, Tiongson C. Guilt and Burnout in Medical Students. Teach Learn Med. 2022 Jan-Mar;34(1):69-77. doi: 10.1080/10401334.2021.1891544. Epub 2021 Mar 15. PMID: 33722144

Nacarelli T, Azar A, Potnis M, Johannes G, Mell J, Johnson FB, Brown-Borg H, Noguchi E, Sell C. The methyltransferase enzymes KMT2D, SETD1B, and ASH1L are key mediators of both metabolic and epigenetic changes during cellular senescence. Mol Biol Cell. 2022 May 1;33(5):ar36. doi: 10.1091/mbc.E20-08-0523. Epub 2022 Feb 23. PMID: 35196069

Schmit T, Guo K, Tripathi JK, Wang Z, McGregor B, Klomp M, Ambigapathy G, Mathur R, Hur J, Pichichero M, Kolls J, Khan MN. Interferon-γ promotes monocyte-mediated lung injury during influenza infection. Cell Rep. 2022 Mar 1;38(9):110456. doi: 10.1016/j.celrep.2022.110456. PMID: 35235782

Campbell KS, Keller PG, Heinzel LM, Golovko SA, Seeger DR, Golovko MY, Kerby JL. Detection of imidacloprid and metabolites in Northern Leopard frog (Rana pipiens) brains. Sci Total Environ. 2022 Mar 20;813:152424. doi: 10.1016/j.scitotenv.2021.152424. Epub 2021 Dec 20. PMID: 34942261

Boison D, Masino SA, Lubin FD, Guo K, Lusardi T, Sanchez R, Ruskin DN, Ohm J, Geiger JD, Hur J. The impact of methodology on the reproducibility and rigor of DNA methylation data. Sci Rep. 2022 Jan 10;12(1):380. doi: 10.1038/s41598-021-04346-w. PMID: 35013473

Li L, Niu M, Erickson A, Luo J, Rowbotham K, Guo K, Huang H, Li Y, Jiang Y, Hur J, Liu C, Peng J, Wang X. SMAP is a pipeline for sample matching in proteogenomics. Nat Commun. 2022 Feb 8;13(1):744. doi: 10.1038/s41467-022-28411-8. PMID: 35136070

Wu Y, Yu Q, Zhang M, Zhou Y, Su X, Wu M, Lv J, Xia Z. Hemin-primed dendritic cells suppress allergic airway inflammation through releasing extracellular vesicles. J Leukoc Biol. 2022 Apr;111(4):837-848. doi: 10.1002/JLB.3A0321-175R. Epub 2021 Jul 23. PMID: 34296788

Solaymani-Mohammadi S. Mucosal Defense Against Giardia at the Intestinal Epithelial Cell Interface. Front Immunol. 2022 Feb 17;13:817468. doi: 10.3389/fimmu.2022.817468. PMID: 35250996

Yu L, Cao Q, Chen W, Yang N, Yang CG, Ji Q, Wu M, Bae T, Lan L. A novel copper-sensing two-component system for inducing Dsb gene expression in bacteria. Sci Bull (Beijing). 2022 Jan 30;67(2):198-212. doi: 10.1016/j.scib.2021.03.003. Epub 2021 Mar 9. PMID: 36546013

Stewart A, Mayer FP, Gowrishankar R, Davis GL, Areal LB, Gresch PJ, Katamish RM, Peart R, Stilley SE, Spiess K, Rabil MJ, Diljohn FA, Wiggins AE, Vaughan RA, Hahn MK, Blakely RD. Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters. Mol Psychiatry. 2022 Dec;27(12):4869-4880. doi: 10.1038/s41380-022-01773-7. Epub 2022 Sep 18. PMID: 36117213

Goutman SA, Guo K, Savelieff MG, Patterson A, Sakowski SA, Habra H, Karnovsky A, Hur J, Feldman EL. Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts. Brain. 2022 Dec 19;145(12):4425-4439. doi: 10.1093/brain/awac025. PMID: 35088843

Bordet G, Karpova I, Tulin AV. Poly(ADP-ribosyl)ating enzymes cooperate to coordinate development. Sci Rep. 2022 Dec 21;12(1):22120. doi: 10.1038/s41598-022-26530-2. PMID: 36543866

Henn RE, Elzinga SE, Glass E, Parent R, Guo K, Allouch AA, Mendelson FE, Hayes J, Webber-Davis I, Murphy GG, Hur J, Feldman EL. Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice. Immun Ageing. 2022 Dec 22;19(1):67. doi: 10.1186/s12979-022-00323-7. PMID: 36550567

Eliazer S, Sun X, Barruet E, Brack AS. Heterogeneous levels of delta-like 4 within a multinucleated niche cell maintains muscle stem cell diversity. Elife. 2022 Dec 30;11:e68180. doi: 10.7554/eLife.68180. PMID: 36583937

Biggane JP, Xu K, Goldenstein BL, Davis KL, Luger EJ, Davis BA, Jurgens CWD, Perez DM, Porter JE, Doze VA. Pharmacological characterization of the α2A-adrenergic receptor inhibiting rat hippocampal CA3 epileptiform activity: comparison of ligand efficacy and potency. J Recept Signal Transduct Res. 2022 Dec;42(6):580-587. doi: 10.1080/10799893.2022.2110896. Epub 2022 Aug 19. PMID: 35984443

Halcrow PW, Lakpa KL, Khan N, Afghah Z, Miller N, Datta G, Chen X, Geiger JD. HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species. J Neuroimmune Pharmacol. 2022 Jun;17(1-2):181-194. doi: 10.1007/s11481-021-09995-2. Epub 2021 Apr 8. PMID: 33834418

Reagen S, Wu Y, Sun D, Munoz C, Oncel N, Combs C, Zhao JX. Development of Biodegradable GQDs-hMSNs for Fluorescence Imaging and Dual Cancer Treatment via Photodynamic Therapy and Drug Delivery. Int J Mol Sci. 2022 Nov 29;23(23):14931. doi: 10.3390/ijms232314931. PMID: 36499261

Cui G, Zhang Y, Xu X, Liu Y, Li Z, Wu M, Liu J, Gan J, Liang H. PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa. Sci Adv. 2022 Dec 9;8(49):eadd4220. doi: 10.1126/sciadv.add4220. Epub 2022 Dec 7. PMID: 36475801

Hashemi-Hafshejani S, Meamar AR, Moradi M, Hemmati N, Solaymani-Mohammadi S, Razmjou E. Multilocus sequence typing of Giardia duodenalis genotypes circulating in humans in a major metropolitan area. Front Med (Lausanne). 2022 Oct 5;9:976956. doi: 10.3389/fmed.2022.976956. PMID: 36275791

Vomhof-DeKrey EE, Singhal S, Singhal SK, Stover AD, Rajpathy O, Preszler E, Garcia L, Basson MD. RNA Sequencing of Intestinal Enterocytes Pre- and Post-Roux-en-Y Gastric Bypass Reveals Alteration in Gene Expression Related to Enterocyte Differentiation, Restitution, and Obesity with Regulation by Schlafen 12. Cells. 2022 Oct 18;11(20):3283. doi: 10.3390/cells11203283. PMID: 36291149

Oncel S, Basson MD. ZINC40099027 promotes monolayer circular defect closure by a novel pathway involving cytosolic activation of focal adhesion kinase and downstream paxillin and ERK1/2. Cell Tissue Res. 2022 Nov;390(2):261-279. doi: 10.1007/s00441-022-03674-1. Epub 2022 Aug 24. PMID: 36001146

Khasabova II, Juliette J, Rogness VM, Khasabov SG, Golovko MY, Golovko SA, Kiven S, Gupta K, Belcher JD, Vercellotti GM, Seybold VS, Simone DA. A model of painful vaso-occlusive crisis in mice with sickle cell disease. Blood. 2022 Oct 20;140(16):1826-1830. doi: 10.1182/blood.2022017309. PMID: 35960856

Reagen S, Wu Y, Shahni R, Sun W, Zhang J, Chu QR, Hou X, Combs C, Zhao JX. Development of Red-Emissive Porphyrin Graphene Quantum Dots (PGQDs) for Biological Cell-Labeling Applications. ACS Omega. 2022 Oct 19;7(43):38902-38911. doi: 10.1021/acsomega.2c04623. PMID: 36340159

Magnuson AD, Bukowski MR, Rosenberger TA, Picklo MJ. Quantifying Sphingomyelin in Dairy through Infusion-Based Shotgun Mass Spectrometry with Lithium-Ion-Induced Fragmentation. J Agric Food Chem. 2022 Oct 26;70(42):13808-13817. doi: 10.1021/acs.jafc.2c04587. Epub 2022 Oct 14. PMID: 36239443

Wang Z, Guo K, Liu Y, Huang C, Wu M. Dynamic impact of virome on colitis and colorectal cancer: Immunity, inflammation, prevention and treatment. Semin Cancer Biol. 2022 Nov;86(Pt 2):943-954. doi: 10.1016/j.semcancer.2021.10.004. Epub 2021 Oct 14. PMID: 34656791

Wijewickrama ES, Thakshila WAG, Ekanayake EMD, Gunasekara TDKS, Chandana EPS, Jayasinghe SS, Ruwanpathirana T, Jayasinghe S, De Silva MCS. Prevalence of CKD of Unknown Etiology and its Potential Risk Factors in a Rural Population in Sri Lanka. Kidney Int Rep. 2022 Aug 3;7(10):2303-2307. doi: 10.1016/j.ekir.2022.07.012. PMID: 36217515

Manni W, Min W. Signaling pathways in the regulation of cancer stem cells and associated targeted therapy. MedComm (2020). 2022 Oct 5;3(4):e176. doi: 10.1002/mco2.176. PMID: 36226253; PMCID: PMC9534377.

Sohrabi M, Sahu B, Kaur H, Hasler WA, Prakash A, Combs CK. Gastrointestinal Changes and Alzheimer's Disease. Curr Alzheimer Res. 2022;19(5):335-350. doi: 10.2174/1567205019666220617121255. PMID: 35718965.

Li L, Shen G, Wu M, Jiang J, Xia Q, Lin P. CRISPR-Cas-mediated diagnostics. Trends Biotechnol. 2022 Nov;40(11):1326-1345. doi: 10.1016/j.tibtech.2022.04.006. Epub 2022 May 17. PMID: 35595574.

Brishti A, Germundson-Hermanson DL, Smith NA, Kearney AE, Warda Y, Nagamoto-Combs K. Asymptomatic sensitization to a cow's milk protein induces sustained neuroinflammation and behavioral changes with chronic allergen exposure. Front Allergy. 2022 Sep 7;3:870628. doi: 10.3389/falgy.2022.870628. PMID: 36157272

Boyle CA, Hu B, Quaintance KL, Mastrud MR, Lei S. Ionic signaling mechanisms involved in neurokinin-3 receptor-mediated augmentation of fear-potentiated startle response in the basolateral amygdala. J Physiol. 2022 Oct;600(19):4325-4345. doi: 10.1113/JP283433. Epub 2022 Sep 13. PMID: 36030507

Saylor TC, Casselli T, Lethbridge KG, Moore JP, Owens KM, Brissette CA, Zückert WR, Stevenson B. Borrelia burgdorferi, the Lyme disease spirochete, possesses genetically-encoded responses to doxycycline, but not to amoxicillin. PLoS One. 2022 Sep 30;17(9):e0274125. doi: 10.1371/journal.pone.0274125. PMID: 36178885

Thompson D, Brissette CA, Watt JA. The choroid plexus and its role in the pathogenesis of neurological infections. Fluids Barriers CNS. 2022 Sep 10;19(1):75. doi: 10.1186/s12987-022-00372-6. PMID: 36088417

Zelewski SK, Basson MD. Design and implementation of a core EPA-based acting internship curriculum. Med Teach. 2022 Aug;44(8):922-927. doi: 10.1080/0142159X.2022.2049732. Epub 2022 Mar 31. PMID: 35358009

Rumora AE, Guo K, Hinder LM, O'Brien PD, Hayes JM, Hur J, Feldman EL. A High-Fat Diet Disrupts Nerve Lipids and Mitochondrial Function in Murine Models of Neuropathy. Front Physiol. 2022 Aug 22;13:921942. doi: 10.3389/fphys.2022.921942. PMID: 36072849

Chen H, Kharerin H, Dhasarathy A, Kladde M, Bai L. Partitioned usage of chromatin remodelers by nucleosome-displacing factors. Cell Rep. 2022 Aug 23;40(8):111250. doi: 10.1016/j.celrep.2022.111250. PMID: 36001970

Brown-Borg HM. Growth Hormone, Not IGF-1 Is the Key Longevity Regulator in Mammals. J Gerontol A Biol Sci Med Sci. 2022 Sep 1;77(9):1719-1723. doi: 10.1093/gerona/glac092. PMID: 35436323

Karpova Y, Johnson SJ, Bordet G, Guo D, Ghatak A, Markov DA, Tulin AV. Upregulation of PARG in prostate cancer cells suppresses their malignant behavior and downregulates tumor-promoting genes. Biomed Pharmacother. 2022 Sep;153:113504. doi: 10.1016/j.biopha.2022.113504. Epub 2022 Aug 1. PMID: 36076593

Cooper M, Ray A, Bhattacharya A, Dhasarathy A, Takaku M. ATAC-seq Optimization for Cancer Epigenetics Research. J Vis Exp. 2022 Jun 30;(184). doi: 10.3791/64242. PMID: 35848835.

Lei S, Boyle CA, Mastrud M. PLCβ-Mediated Depletion of PIP2 and ATP-Sensitive K+ Channels Are Involved in Arginine Vasopressin-Induced Facilitation of Neuronal Excitability and LTP in the Dentate Gyrus. eNeuro. 2022 Jul 19;9(4):ENEURO.0120-22.2022. doi: 10.1523/ENEURO.0120-22.2022. PMID: 35788107.

Qin S, Xiao W, Zhou C, Pu Q, Deng X, Lan L, Liang H, Song X, Wu M. Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics. Signal Transduct Target Ther. 2022 Jun 25;7(1):199. doi: 10.1038/s41392-022-01056-1. PMID: 35752612; PMCID: PMC9233671.

Rowbotham K, Hanson B, Haugen J, Milavetz B. Early in an SV40 infection, histone modifications correlate with the presence or absence of RNAPII and direction of transcription. Virology. 2022 Aug;573:59-71. doi: 10.1016/j.virol.2022.05.009. Epub 2022 Jun 8. PMID: 35717712.

Xu X, Yan Y, Huang J, Zhang Z, Wang Z, Wu M, Liang H. Regulation of uric acid and glyoxylate metabolism by UgmR protein in Pseudomonas aeruginosa. Environ Microbiol. 2022 Jul;24(7):3242-3255. doi: 10.1111/1462-2920.16088. PMID: 35702827.

Li H, Wu M, Zhao X. Role of chemokine systems in cancer and inflammatory diseases. MedComm (2020). 2022 Jun 8;3(2):e147. doi: 10.1002/mco2.147. PMID: 35702353; PMCID: PMC9175564.

Weisel CL, Dyke CM, Klug MG, Haldis TA, Basson MD. Day-to-day blood pressure variability predicts poor outcomes following percutaneous coronary intervention: A retrospective study. World J Cardiol. 2022 May 26;14(5):307-318. doi: 10.4330/wjc.v14.i5.307. PMID: 35702324.

Raihan MO, Espelien BM, Hanson C, McGregor BA, Velaris NA, Alvine TD, Al Golovko S, Bradley DS, Nilles M, Glovko MY, Hur J, Porter JE. Characterization of prostanoids response to Bordetella pertussis antigen BscF and Tdap in LPS-challenged monocytes. Prostaglandins Leukot Essent Fatty Acids. 2022 Jul;182:102452. doi: 10.1016/j.plefa.2022.102452. Epub 2022 May 21. PMID: 35690004.

Halcrow PW, Kumar N, Quansah DNK, Baral A, Liang B, Geiger JD. Endolysosome Iron Chelation Inhibits HIV-1 Protein-Induced Endolysosome De-Acidification-Induced Increases in Mitochondrial Fragmentation, Mitophagy, and Cell Death. Cells. 2022 May 31;11(11):1811. doi: 10.3390/cells11111811. PMID: 35681506.

Huffman A, Ong E, Hur J, D'Mello A, Tettelin H, He Y. COVID-19 vaccine design using reverse and structural vaccinology, ontology-based literature mining and machine learning. Brief Bioinform. 2022 Jul 18;23(4):bbac190. doi: 10.1093/bib/bbac190. PMID: 35649389.

Wang B, Zhou C, Wu Q, Lin P, Pu Q, Qin S, Gao P, Wang Z, Liu Y, Arel J, Chen Y, Chen T, Wu M. cGAS modulates cytokine secretion and bacterial burdens by altering the release of mitochondrial DNA in pseudomonas pulmonary infection. Immunology. 2022 Jul;166(3):408-423. doi: 10.1111/imm.13482. Epub 2022 May 4. PMID: 35420160.

Sharma A, Chauhan A, Chauhan P, Evans DL, Szlabick RE, Aaland MO, Mishra BB, Sharma J. Glycolipid Metabolite β-Glucosylceramide Is a Neutrophil Extracellular Trap-Inducing Ligand of Mincle Released during Bacterial Infection and Inflammation. J Immunol. 2022 Jul 15;209(2):391-400. doi: 10.4049/jimmunol.2100855. Epub 2022 Jun 29. PMID 35768151

Germundson DL, Nookala S, Smith NA, Warda Y, Nagamoto-Combs K. HLA-II Alleles Influence Physical and Behavioral Responses to a Whey Allergen in a Transgenic Mouse Model of Cow's Milk Allergy. Front Allergy. 2022 Apr 14;3:870513. doi: 10.3389/falgy.2022.870513. PMID: 35769584

Wu Q, Cui L, Liu Y, Li R, Dai M, Xia Z, Wu M. CRISPR-Cas systems target endogenous genes to impact bacterial physiology and alter mammalian immune responses. Mol Biomed. 2022 Jul 20;3(1):22. doi: 10.1186/s43556-022-00084-1. PMID: 35854035.

Md.Obayed Raihan, Brenna M. Espelien, Courtney Hanson, Brett A. McGregor, Nathan A. Velaris, Travis D. Alvine, Svetlana Al. Golovko, David S. Bradley, Matthew Nilles, Mikhail Y. Golovko, Junguk Hur, James E. Porter. Characterization of prostanoids response to Bordetella pertussis antigen BscF and Tdap in LPS-challenged monocytes. Prostaglandins, Leukotrienes and Essential Fatty Acids, Volume 182, 2022, 102452, ISSN 0952-3278,

Gunasekara TDKSC, De Silva PMCS, Ekanayake EMDV, Thakshila WAKG, Pinipa RAI, Sandamini PMMA, Gunarathna SD, Chandana EPS, Jayasinghe SS, Herath C, Siribaddana S, Jayasundara N. Urinary biomarkers indicate pediatric renal injury among rural farming communities in Sri Lanka. Sci Rep. 2022 May 16;12(1):8040. doi: 10.1038/s41598-022-10874-w. PMID: 35577796; PMCID: PMC9110366.

Pandey S, Bruns HA, Condry DLJ, Kleinschmit AJ, Lal A, Sletten S, Sparks-Thissen RL, Vanniasinkam T, Taylor RT, Justement LB, Elliott SL. Antigen and Immunogen: An Investigation into the Heterogeneity of Immunology Terminology in Learning Resources. Immunohorizons. 2022 May 31;6(5):312-323. doi: 10.4049/immunohorizons.2200004. PMID: 35641147.

Ekanayake EMDV, Gunasekara TDKSC, De Silva PMCS, Jayasinghe S, Chandana EPS, Jayasundara N. Applicability of Novel Urinary Biomarkers for the Assessment of Renal Injury in Selected Occupational Groups in Sri Lanka: A Comparative Study with Conventional Markers. Int J Environ Res Public Health. 2022 Apr 26;19(9):5264. doi: 10.3390/ijerph19095264. PMID: 35564662; PMCID: PMC9099841.

McGregor BA, Schommer J, Guo K, Obayed Raihan M, Ghribi O, Hur J, Porter JE. Corrigendum to "Alpha-Synuclein-induced DNA Methylation and Gene Expression in Microglia" [Neuroscience 468 (2021) 186-198]. Neuroscience. 2022 Jun 1;492:108. doi: 10.1016/j.neuroscience.2022.04.021. Epub 2022 May 2. Erratum for: Neuroscience. 2021 Aug 1;468:186-198. PMID: 35513021.

Liu Y, Zhang C, Wu M. Prokaryotic gasdermins: ancestors of eukaryotic counterparts direct the pyroptosis and cell fates. Signal Transduct Target Ther. 2022 May 7;7(1):152. doi: 10.1038/s41392-022-01005-y. PMID: 35525842; PMCID: PMC9079055.

Lin P, Shen G, Guo K, Qin S, Pu Q, Wang Z, Gao P, Xia Z, Khan N, Jiang J, Xia Q, Wu M. Type III CRISPR-based RNA editing for programmable control of SARS-CoV-2 and human coronaviruses. Nucleic Acids Res. 2022 May 6;50(8):e47. doi: 10.1093/nar/gkac016. PMID: 35166837; PMCID: PMC9071467.

Johnson S, Karpova Y, Guo D, Ghatak A, Markov DA, Tulin AV. PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment. BMC Cancer. 2022 May 18;22(1):557. doi: 10.1186/s12885-022-09651-9. PMID: 35585513; PMCID: PMC9118775.

Oncel S, Basson MD. Gut homeostasis, injury, and healing: New therapeutic targets. World J Gastroenterol. 2022 May 7;28(17):1725-1750. doi: 10.3748/wjg.v28.i17.1725. PMID: 35633906; PMCID: PMC9099196.

Qin S, Tang X, Chen Y, Chen K, Fan N, Xiao W, Zheng Q, Li G, Teng Y, Wu M, Song X. mRNA-based therapeutics: powerful and versatile tools to combat diseases. Signal Transduct Target Ther. 2022 May 21;7(1):166. doi: 10.1038/s41392-022-01007-w. PMID: 35597779; PMCID: PMC9123296.

Perazza LR, Brown-Borg HM, Thompson LV. Physiological Systems in Promoting Frailty. Compr Physiol. 2022 Apr 26;12(3):1-46. doi: 10.1002/cphy.c210034. PMID: 35578945.

Kalyan G, Slusser-Nore A, Dunlevy JR, Bathula CS, Shabb JB, Muhonen W, Somji S, Sens DA, Garrett SH. Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells. PLoS One. 2022 May 3;17(5):e0267599. doi: 10.1371/journal.pone.0267599. PMID: 35503771

Raafat Elsayed AA, Al-Marsoummi S, Vomhof-Dekrey EE, Basson MD. SLFN12 Over-expression Sensitizes Triple Negative Breast Cancer Cells to Chemotherapy Drugs and Radiotherapy. Cancer Genomics Proteomics. 2022 May-Jun;19(3):328-338. doi: 10.21873/cgp.20323. PMID: 35430566

Murphy EJ. Glucose as a carbon source to synthesize palmitate de novo in the adult rodent brain: Adding to the carbon recycling story in the brain. J Neurochem. 2022 Apr;161(2):109-111. doi: 10.1111/jnc.15592. Epub 2022 Feb 27. PMID: 35224738.

Raihan MO, Espelien BM, McGregor BA, Hanson C, Brishti A, Velaris NA, Alvine TD, Bradley DS, Nilles M, Golovko MY, Hur J, Porter JE. Modulation of Inflammatory Signaling Molecules in Bordetella pertussis Antigen-Challenged Human Monocytes in Presence of Adrenergic Agonists. Vaccines (Basel). 2022 Feb 17;10(2):321. doi: 10.3390/vaccines10020321. PMID: 35214778

Guo K, Savelieff MG, Rumora AE, Alakwaa FM, Callaghan BC, Hur J, Feldman EL. Plasma Metabolomics and Lipidomics Differentiate Obese Individuals by Peripheral Neuropathy Status. J Clin Endocrinol Metab. 2022 Mar 24;107(4):1091-1109. doi: 10.1210/clinem/dgab844. PMID: 34878536

Erickson OA, Cole RB, Isaacs JM, Alvarez-Clare S, Arnold J, Augustus-Wallace A, Ayoob JC, Berkowitz A, Branchaw J, Burgio KR, Cannon CH, Ceballos RM, Cohen CS, Coller H, Disney J, Doze VA, Eggers MJ, Farina S, Ferguson EL, Gray JJ, Greenberg JT, Hoffmann A, Jensen-Ryan D, Kao RM, Keene AC, Kowalko JE, Lopez SA, Mathis C, Minkara M, Murren CJ, Ondrechen MJ, Ordoñez P, Osano A, Padilla-Crespo E, Palchoudhury S, Qin H, Ramírez-Lugo J, Reithel J, Shaw CA, Smith A, Smith R, Summers AP, Tsien F, Dolan EL. "How Do We Do This at a Distance?!" A Descriptive Study of Remote Undergraduate Research Programs during COVID-19. CBE Life Sci Educ. 2022 Mar;21(1):ar1. doi: 10.1187/cbe.21-05-0125. PMID: 34978923

Campbell KS, Keller PG, Heinzel LM, Golovko SA, Seeger DR, Golovko MY, Kerby JL. Detection of imidacloprid and metabolites in Northern Leopard frog (Rana pipiens) brains. Sci Total Environ. 2022 Mar 20;813:152424. doi: 10.1016/j.scitotenv.2021.152424. Epub 2021 Dec 20. PMID: 34942261.

2021 Publications

Datta G, Miller NM, Du W, Geiger JD, Chang S, Chen X. Endolysosome Localization of ERα Is Involved in the Protective Effect of 17α-Estradiol against HIV-1 gp120-Induced Neuronal Injury. J Neurosci. 2021 Dec 15;41(50):10365-10381. doi: 10.1523/JNEUROSCI.1475-21.2021. Epub 2021 Nov 11. PMID: 34764157; PMCID: PMC8672688.

Bordet G, Lodhi N, Kossenkov A, Tulin A. Age-Related Changes of Gene Expression Profiles in Drosophila. Genes (Basel). 2021 Dec 14;12(12):1982. doi: 10.3390/genes12121982. PMID: 34946931; PMCID: PMC8701748.

Raihan MO, McGregor BA, Velaris NA, Brishti A, Hur J, Porter JE. Method of Microglial DNA-RNA Purification from a Single Brain of an Adult Mouse. Methods Protoc. 2021 Dec 2;4(4):86. doi: 10.3390/mps4040086. PMID: 34940397; PMCID: PMC8704779.

Kumar N, Khan N, Cleveland D, Geiger JD. A common approach for fighting tuberculosis and leprosy: controlling endoplasmic reticulum stress in myeloid-derived suppressor cells. Immunotherapy. 2021 Dec;13(18):1555-1563. doi: 10.2217/imt-2021-0197. Epub 2021 Nov 8. PMID: 34743608.

Zhu R, Yan T, Feng Y, Liu Y, Cao H, Peng G, Yang Y, Xu Z, Liu J, Hou W, Wang X, Li Z, Deng L, Wang S, Li J, Han Q, Li H, Shan G, Cao Y, An X, Yan J, Zhang Z, Li H, Qu X, Zhu J, Zhou S, Wang J, Zhang F, Gao J, Jin R, Xu D, Ma YQ, Huang T, Peng S, Zheng Z, Stambler I, Gilson E, Lim LW, Moskalev A, Cano A, Chakrabarti S, Ulfhake B, Su H, Xu H, Xu S, Wei F, Brown-Borg HM, Min KJ, Ellison-Hughes G, Caruso C, Jin K, Zhao RC. Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms. Cell Res. 2021 Dec;31(12):1244-1262. doi: 10.1038/s41422-021-00573-y. Epub 2021 Oct 26. PMID: 34702946

Zhang M, Yu Q, Tang W, Wu Y, Lv J, Sun L, Shi G, Wu M, Qu J, Di C, Xia Z. Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell-dominant T-cell responses in asthma. J Allergy Clin Immunol. 2021 Dec;148(6):1545-1558. doi: 10.1016/j.jaci.2021.04.025. Epub 2021 May 4. PMID: 33957164.

Bartke A, Brown-Borg H. Mutations Affecting Mammalian Aging: GH and GHR vs IGF-1 and Insulin. Front Genet. 2021 Nov 24;12:667355. doi: 10.3389/fgene.2021.667355. PMID: 34899820

Nascimento Da Conceicao V, Sun Y, Ramachandran K, Chauhan A, Raveendran A, Venkatesan M, DeKumar B, Maity S, Vishnu N, Kotsakis GA, Worley PF, Gill DL, Mishra BB, Madesh M, Singh BB. Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics. iScience. 2021 Oct 23;24(11):103339. doi: 10.1016/j.isci.2021.103339. PMID: 34816101

Chowdhury D, Gardner JC, Satpati A, Nookala S, Mukundan S, Porollo A, Landero Figueroa JA, Subramanian Vignesh K. Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity. Front Immunol. 2021 Nov 12;12:755961. doi: 10.3389/fimmu.2021.755961. PMID: 34867993

Halcrow PW, Lynch ML, Geiger JD, Ohm JE. Role of endolysosome function in iron metabolism and brain carcinogenesis. Semin Cancer Biol. 2021 Nov;76:74-85. doi: 10.1016/j.semcancer.2021.06.013. Epub 2021 Jun 15. PMID: 34139350; PMCID: PMC8627927

Walters DC, Lawrence R, Kirby T, Ahrendsen JT, Anderson MP, Roullet JB, Murphy EJ, Gibson KM; SSADH Deficiency Investigators Consortium (SDIC). Postmortem Analyses in a Patient With Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): II. Histological, Lipid, and Gene Expression Outcomes in Regional Brain Tissue. J Child Neurol. 2021 Nov;36(13-14):1177-1188. doi: 10.1177/0883073820987742. Epub 2021 Feb 9. PMID: 33557678

Hovde MJ, Bolland DE, Armand A, Pitsch E, Bakker C, Kooiker AJ, Provost JJ, Vaughan RA, Wallert MA, Foster JD. Sodium hydrogen exchanger (NHE1) palmitoylation and potential functional regulation. Life Sci. 2022 Jan 1;288:120142. doi: 10.1016/j.lfs.2021.120142. Epub 2021 Nov 11. PMID: 34774621; PMCID: PMC8692447.

Erickson OA, Cole RB, Isaacs JM, Alvarez-Clare S, Arnold J, Augustus-Wallace A, Ayoob JC, Berkowitz A, Branchaw J, Burgio KR, Cannon CH, Ceballos RM, Cohen CS, Coller H, Disney J, Doze VA, Eggers MJ, Farina S, Ferguson EL, Gray JJ, Greenberg JT, Hoffmann A, Jensen-Ryan D, Kao RM, Keene AC, Kowalko JE, Lopez SA, Mathis C, Minkara M, Murren CJ, Ondrechen MJ, Ordoñez P, Osano A, Padilla-Crespo E, Palchoudhury S, Qin H, Ramírez-Lugo J, Reithel J, Shaw CA, Smith A, Smith R, Summers AP, Tsien F, Dolan EL. "How Do We Do This at a Distance?!" A Descriptive Study of Remote Undergraduate Research Programs during COVID-19. CBE Life Sci Educ. 2022 Mar;21(1):ar1. doi: 10.1187/cbe.21-05-0125. PMID: 34978923.

Datta G, Miller NM, Halcrow PW, Khan N, Colwell T, Geiger JD, Chen X. SARS-CoV-2 S1 Protein Induces Endolysosome Dysfunction and Neuritic Dystrophy. Front Cell Neurosci. 2021 Oct 27;15:777738. doi: 10.3389/fncel.2021.777738. PMID: 34776872; PMCID: PMC8579006.

Lo TW, Figueroa-Romero C, Hur J, Pacut C, Stoll E, Spring C, Lewis R, Nair A, Goutman SA, Sakowski SA, Nagrath S, Feldman EL. Extracellular Vesicles in Serum and Central Nervous System Tissues Contain microRNA Signatures in Sporadic Amyotrophic Lateral Sclerosis. Front Mol Neurosci. 2021 Oct 29;14:739016. doi: 10.3389/fnmol.2021.739016. PMID: 34776863; PMCID: PMC8586523.

Sueker M, Stromsodt K, Gorji HT, Vasefi F, Khan N, Schmit T, Varma R, Mackinnon N, Sokolov S, Akhbardeh A, Liang B, Qin J, Chan DE, Baek I, Kim MS, Tavakolian K. Handheld Multispectral Fluorescence Imaging System to Detect and Disinfect Surface Contamination. Sensors (Basel). 2021 Oct 30;21(21):7222. doi: 10.3390/s21217222. PMID: 34770529.

Pabis K, Chiari Y, Sala C, Straka E, Giacconi R, Provinciali M, Li X, Brown-Borg H, Nowikovsky K, Valencak TG, Gundacker C, Garagnani P, Malavolta M. Elevated metallothionein expression in long-lived species mediates the influence of cadmium accumulation on aging. Geroscience. 2021 Aug;43(4):1975-1993. doi: 10.1007/s11357-021-00393-3. Epub 2021 Jun 11. PMID: 34117600.

Adeluwa T, McGregor BA, Guo K, Hur J. https://pubmed.ncbi.nlm.nih.gov/34483896/. Front Pharmacol. 2021 Aug 18;12:648805. doi: 10.3389/fphar.2021.648805. PMID: 34483896; PMCID: PMC8416433.

Al-Marsoummi S, Vomhof-DeKrey EE, Basson MD. Schlafens: Emerging Proteins in Cancer Cell Biology. Cells. 2021 Aug 29;10(9):2238. doi: 10.3390/cells10092238. PMID: 34571887; PMCID: PMC8465726.

Orysiak J, Tripathi JK, Brodaczewska K, Sharma A, Witek K, Sitkowski D, Malczewska-Lenczowska J. The impact of physical training on neutrophil extracellular traps in young male athletes - a pilot study. Biol Sport. 2021 Sep;38(3):459-464. doi: 10.5114/biolsport.2021.101117. Epub 2020 Nov 9. PMID: 34475627; PMCID: PMC8329969.

Liu W, Li L, Jiang J, Wu M, Lin P. Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics. Precis Clin Med. 2021 Jul 10;4(3):179-191. doi: 10.1093/pcmedi/pbab014. PMID: 34541453; PMCID: PMC8444435.

Kaur H, Nookala S, Singh S, Mukundan S, Nagamoto-Combs K, Combs CK. Sex-Dependent Effects of Intestinal Microbiome Manipulation in a Mouse Model of Alzheimer's Disease. Cells. 2021 Sep 9;10(9):2370. doi: 10.3390/cells10092370. PMID: 34572019; PMCID: PMC8469717.

Reagen S, Wu Y, Liu X, Shahni R, Bogenschuetz J, Wu X, Chu QR, Oncel N, Zhang J, Hou X, Combs C, Vasquez A, Zhao JX. Synthesis of Highly Near-Infrared Fluorescent Graphene Quantum Dots Using Biomass-Derived Materials for In Vitro Cell Imaging and Metal Ion Detection. ACS Appl Mater Interfaces. 2021 Sep 22;13(37):43952-43962. doi: 10.1021/acsami.1c10533. Epub 2021 Sep 8. PMID: 34495635.

Khan N, Halcrow PW, Lakpa LK, Rehan M, Chen X, Geiger JD. Endolysosome iron restricts Tat-mediated HIV-1 LTR transactivation by increasing HIV-1 Tat oligomerization and β-catenin expression. J Neurovirol. 2021 Sep 22. doi: 10.1007/s13365-021-01016-5. Epub ahead of print. PMID: 34550543.

Sletten SR. Rethinking Assessment: Replacing Traditional Exams with Paper Reviews. J Microbiol Biol Educ. 2021 Jun 30;22(2):e00109-21. doi: 10.1128/jmbe.00109-21. PMID: 34594442; PMCID: PMC8442008.

Ansari KI, Bhan A, Saotome M, Tyagi A, De Kumar B, Chen C, Takaku M, Jandial R. Autocrine GM-CSF signaling contributes to growth of HER2+ breast leptomeningeal carcinomatosis. Cancer Res. 2021 Jul 9:canres.0259.2021. doi: 10.1158/0008-5472.CAN-21-0259. Epub ahead of print. PMID: 34247146.

Hu B, Boyle CA, Lei S. Roles of PLCβ, PIP2 , and GIRK channels in arginine vasopressin-elicited excitation of CA1 pyramidal neurons. J Cell Physiol. 2021 Jul 20. doi: 10.1002/jcp.30535. Epub ahead of print. PMID: 34287874.

Wu Y, Yu Q, Zhang M, Zhou Y, Su X, Wu M, Lv J, Xia Z. Hemin-primed dendritic cells suppress allergic airway inflammation through releasing extracellular vesicles. J Leukoc Biol. 2021 Jul 23. doi: 10.1002/JLB.3A0321-175R. Epub ahead of print. PMID: 34296788.

Khan N, Geiger JD. Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis. Viruses. 2021 Jul 27;13(8):1466. doi: 10.3390/v13081466. PMID: 34452331

Paluck A., Osan J., Hollingsworth L., Talukdar S.N., Saegh A.A., and Mehedi M. Role of ARP2/3 complex-driven actin polymerization in RSV infection. Pathogens. 2021  Dec 26, 11(1): 26

De Silva PMCS, Gunasekara TDKSC, Gunarathna SD, Sandamini PMMA, Pinipa RAI, Ekanayake EMDV, Thakshila WAKG, Jayasinghe SS, Chandana EPS, Jayasundara N. Urinary Biomarkers of Renal Injury KIM-1 and NGAL: Reference Intervals for Healthy Pediatric Population in Sri Lanka. Children (Basel). 2021 Aug 9;8(8):684. doi: 10.3390/children8080684. PMID: 34438575

Vomhof-DeKrey EE, Stover A, Basson MD. Microbiome diversity declines while distinct expansions of Th17, iNKT, and dendritic cell subpopulations emerge after anastomosis surgery. Gut Pathog. 2021 Aug 10;13(1):51. doi: 10.1186/s13099-021-00447-z. PMID: 34376235

Yu Y, Zhou Y, Di C, Zhao C, Chen J, Su W, Wu Q, Wu M, Su X, Xia Z. Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding. J Cell Mol Med. 2021 Aug 20. doi: 10.1111/jcmm.16843. Epub ahead of print. PMID: 34414666.

Osan JK, DeMontigny BA, Mehedi M. Immunohistochemistry for protein detection in PFA-fixed paraffin-embedded SARS-CoV-2-infected COPD airway epithelium. STAR Protoc. 2021 Sep 17;2(3):100663. doi: 10.1016/j.xpro.2021.100663. Epub 2021 Jun 18. PMID: 34250510; PMCID: PMC8259228.

Xiao F, Sasi PC, Alinezhad A, Golovko SA, Golovko MY, Spoto A. Thermal Decomposition of Anionic, Zwitterionic, and Cationic Polyfluoroalkyl Substances in Aqueous Film-Forming Foams. Environ Sci Technol. 2021 Jul 20;55(14):9885-9894. doi: 10.1021/acs.est.1c02125. Epub 2021 Jul 8. PMID: 34235932.

Kaur H, Seeger D, Golovko S, Golovko M, Combs CK. Liver Bile Acid Changes in Mouse Models of Alzheimer's Disease. Int J Mol Sci. 2021 Jul 12;22(14):7451. doi: 10.3390/ijms22147451. PMID: 34299071; PMCID: PMC8303891.

Lei S, Hu B. Ionic and signaling mechanisms involved in neurotensin-mediated excitation of central amygdala neurons. Neuropharmacology. 2021 Jul 14;196:108714. doi: 10.1016/j.neuropharm.2021.108714. Epub ahead of print. PMID: 34271017.

Hu B, Boyle CA, Lei S. Roles of PLCβ, PIP2 , and GIRK channels in arginine vasopressin-elicited excitation of CA1 pyramidal neurons. J Cell Physiol. 2021 Jul 20. doi: 10.1002/jcp.30535. Epub ahead of print. PMID: 34287874.

Wu Y, Yu Q, Zhang M, Zhou Y, Su X, Wu M, Lv J, Xia Z. Hemin-primed dendritic cells suppress allergic airway inflammation through releasing extracellular vesicles. J Leukoc Biol. 2021 Jul 23. doi: 10.1002/JLB.3A0321-175R. Epub ahead of print. PMID: 34296788.

Zhang M, Yu Q, Tang W, Wu Y, Lv J, Sun L, Shi G, Wu M, Qu J, Di C, Xia Z. Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell-dominant T-cell responses in asthma. J Allergy Clin Immunol. 2021 May 4:S0091-6749(21)00720-X. doi: 10.1016/j.jaci.2021.04.025. Epub ahead of print. PMID: 33957164.

Bian G, Gu Y, Xu C, Yang W, Pan X, Chen Y, Lai M, Zhou Y, Dong Y, Mao B, Zhou Q, Chen B, Nakathata T, Shi L, Wu M, Zhang Y, Ma F. Early development and functional properties of tryptase/chymase double-positive mast cells from human pluripotent stem cells. J Mol Cell Biol. 2021 May 7;13(2):104-115. doi: 10.1093/jmcb/mjaa059. PMID: 33125075; PMCID: PMC8104937.

Sasi PC, Alinezhad A, Yao B, Kubátová A, Golovko SA, Golovko MY, Xiao F. Effect of granular activated carbon and other porous materials on thermal decomposition of per- and polyfluoroalkyl substances: Mechanisms and implications for water purification. Water Res. 2021 Jul 15;200:117271. doi: 10.1016/j.watres.2021.117271. Epub 2021 May 19. PMID: 34082264.

McGregor BA, Schommer J, Guo K, Obayed Raihan M, Ghribi O, Hur J, Porter JE. Alpha-Synuclein-induced DNA Methylation and Gene Expression in Microglia. Neuroscience. 2021 May 31:S0306-4522(21)00274-8. doi: 10.1016/j.neuroscience.2021.05.027. Epub ahead of print. PMID: 34082066.

Sens DA, Bobylev M, Cisek KL, Garrett SH, Somji S, Sens MA, Doze VA. Postbaccalaureate terminal degree and career choices of students who performed undergraduate research. Adv Physiol Educ. 2021 Jun 1;45(2):418-425. doi: 10.1152/advan.00217.2020. PMID: 34018834.

Benolken MM, Meduna AE, Klug MG, Basson MD. Preoperative and Intraoperative Blood Pressure Variability Independently Correlate With Outcomes. J Surg Res. 2021 Jun 1;266:387-397. doi: 10.1016/j.jss.2021.04.027. Epub ahead of print. PMID: 34087623.

Pu Q, Guo K, Lin P, Wang Z, Qin S, Gao P, Combs C, Khan N, Xia Z, Wu M. Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection. Signal Transduct Target Ther. 2021 Jun 4;6(1):210. doi: 10.1038/s41392-021-00602-7. PMID: 34083514

De Kumar B, Darland DC. The Hox protein conundrum: The "specifics" of DNA binding for Hox proteins and their partners. Dev Biol. 2021 Jun 6;477:284-292. doi: 10.1016/j.ydbio.2021.06.002. Epub ahead of print. PMID: 34102167.

Basson MD, Newman WE, Klug MG. Correlations among visit to visit blood pressure variability and treatment with antihypertensive medication with long term adverse outcomes in a large veteran cohort. Am J Hypertens. 2021 Jun 11:hpab087. doi: 10.1093/ajh/hpab087. Epub ahead of print. PMID: 34115112.

Pabis K, Chiari Y, Sala C, Straka E, Giacconi R, Provinciali M, Li X, Brown-Borg H, Nowikovsky K, Valencak TG, Gundacker C, Garagnani P, Malavolta M. Elevated metallothionein expression in long-lived species mediates the influence of cadmium accumulation on aging. Geroscience. 2021 Jun 11. doi: 10.1007/s11357-021-00393-3. Epub ahead of print. PMID: 34117600.

Halcrow PW, Lynch ML, Geiger JD, Ohm JE. Role of endolysosome function in iron metabolism and brain carcinogenesis. Semin Cancer Biol. 2021 Jun 15:S1044-579X(21)00183-8. doi: 10.1016/j.semcancer.2021.06.013. Epub ahead of print. PMID: 34139350.

Pu Q, Lin P, Gao P, Wang Z, Guo K, Qin S, Zhou C, Wang B, Wu E, Khan N, Xia Z, Wei X, Wu M. Gut Microbiota Regulate Gut-Lung Axis Inflammatory Responses by Mediating ILC2 Compartmental Migration. J Immunol. 2021 Jun 16:ji2001304. doi: 10.4049/jimmunol.2001304. Epub ahead of print. PMID: 34135060.

Chauhan A, Sharma A, Tripathi JK, Sun Y, Sukumran P, Singh BB, Mishra BB, Sharma J. Helminth derived factors inhibit neutrophil extracellular trap formation and inflammation in bacterial peritonitis. Sci Rep. 2021 Jun 16;11(1):12718. doi: 10.1038/s41598-021-92001-9. PMID: 34135384

Sletten, Sarah R. Rethinking Assessment: Replacing Traditional Exams with Paper Reviews. Journal of Microbiology & Biology Education.DOI: https://doi.org/10.1128/jmbe. 00109-21

Oncel S, Gupta R, Wang Q, Basson MD. ZINC40099027 Promotes Gastric Mucosal Repair in Ongoing Aspirin-Associated Gastric Injury by Activating Focal Adhesion Kinase. Cells. 2021 Apr 15;10(4):908. doi: 10.3390/cells10040908. PMID: 33920786; PMCID: PMC8071155.

Lei S, Hu B, Rezagholizadeh N. Activation of V1a vasopressin receptors excite subicular pyramidal neurons by activating TRPV1 and depressing GIRK channels. Neuropharmacology. 2021 Apr 20;190:108565. doi: 10.1016/j.neuropharm.2021.108565. Epub ahead of print. PMID: 33891950.

Boyle CA, Hu B, Quaintance KL, Lei S. Involvement of TRPC5 channels, inwardly rectifying K+ channels, PLCβ and PIP2 in vasopressin-mediated excitation of medial central amygdala neurons. J Physiol. 2021 Apr 19. doi: 10.1113/JP281260. Epub ahead of print. PMID: 33871877.

Lin P, Jiang J, Wu M. CRISPR base editor treats premature-aging syndrome. Signal Transduct Target Ther. 2021 Apr 16;6(1):158. doi: 10.1038/s41392-021-00576-6. PMID: 33863871; PMCID: PMC8050807.

Trivedi R, Knopf B, Tripathi JK, Rakoczy S, Manocha GD, Brown-Borg H, Jurivich DA. Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice. Geroscience. 2021 Apr 13. doi: 10.1007/s11357-021-00362-w. Epub ahead of print. PMID: 33846884.

He X, Wang M, Wu M. FcγRIIb blockage: a promising immunotherapy target for severe COVID-19. Signal Transduct Target Ther. 2021 Apr 9;6(1):147. doi: 10.1038/s41392-021-00590-8. PMID: 33837193; PMCID: PMC8032849.

Halcrow PW, Lakpa KL, Khan N, Afghah Z, Miller N, Datta G, Chen X, Geiger JD. HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species. J Neuroimmune Pharmacol. 2021 Apr 8. doi: 10.1007/s11481-021-09995-2. Epub ahead of print. PMID: 33834418.

Eid SA, Hinder LM, Zhang H, Eksi R, Nair V, Eddy S, Eichinger F, Park M, Saha J, Berthier CC, Jagadish HV, Guan Y, Pennathur S, Hur J, Kretzler M, Feldman EL, Brosius FC. Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice: Predictors of pathology and RAS blockade effects. FASEB J. 2021 May;35(5):e21467. doi: 10.1096/fj.202002387R. PMID: 33788970.

Jain S, Abrham E, Khan MN, Mathur R. An Account of Immune Senescence in the Clinical Pathophysiology of COVID-19 Infection in Aging. Aging Dis. 2021 Apr 1;12(2):662-670. doi: 10.14336/AD.2020.1019. PMID: 33815889; PMCID: PMC7990370.

Rashmi, More SK, Wang Q, Vomhof-DeKrey EE, Porter JE, Basson MD. ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain. Pharmacol Res Perspect. 2021 Apr;9(2):e00737. doi: 10.1002/prp2.737. PMID: 33715263; PMCID: PMC7955952.

Ward SE, O'Sullivan JM, Moran AB, Spencer DIR, Gardner RA, Sharma J, Fazavana J, Monopoli M, McKinnon TAJ, Chion A, Haberichter S, Donnell JSO. Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin mediated clearance. Haematologica. 2021 Mar 25. doi: 10.3324/haematol.2020.274720. Epub ahead of print. PMID: 33763999.

Abdul KSM, De Silva PMCS, Ekanayake EMDV, Thakshila WAKG, Gunarathna SD, Gunasekara TDKSC, Jayasinghe SS, Asanthi HB, Chandana EPS, Chaminda GGT, Siribaddana SH, Jayasundara N. Occupational Paraquat and Glyphosate Exposure May Decline Renal Functions among Rural Farming Communities in Sri Lanka. Int J Environ Res Public Health. 2021 Mar 22;18(6):3278. doi: 10.3390/ijerph18063278. PMID: 33810013.

Greenmyer JR, Montgomery M, Hosford C, Burd M, Miller V, Storandt MH, Lakpa KL, Tiongson C. Guilt and Burnout in Medical Students. Teach Learn Med. 2021 Mar 15:1-9. doi: 10.1080/10401334.2021.1891544. Epub ahead of print. PMID: 33722144.

Kalidhindi RSR, Ambhore NS, Balraj P, Schmit T, Khan MN, Sathish V. Androgen receptor activation alleviates airway hyperresponsiveness, inflammation and remodeling in a murine model of asthma. Am J Physiol Lung Cell Mol Physiol. 2021 Mar 10. doi: 10.1152/ajplung.00441.2020. Epub ahead of print. PMID: 33719566.

Smith NA, Germundson DL, Gao P, Hur J, Floden AM, Nagamoto-Combs K. Anxiety-like behavior and intestinal microbiota changes as strain-and sex-dependent sequelae of mild food allergy in mouse models of cow's milk allergy. Brain Behav Immun. 2021 Mar 9:S0889-1591(21)00104-5. doi: 10.1016/j.bbi.2021.03.002. Epub ahead of print. PMID: 33705867.

Anderson C, Brissette CA. The Brilliance of Borrelia: Mechanisms of Host Immune Evasion by Lyme Disease-Causing Spirochetes. Pathogens. 2021 Mar 2;10(3):281. doi: 10.3390/pathogens10030281. PMID: 33801255.

Wang Q, Gallardo-Macias R, Rashmi, Golovko MY, Elsayed AAR, More SK, Oncel S, Gurvich VJ, Basson MD. Discovery of Novel Small-Molecule FAK Activators Promoting Mucosal Healing. ACS Med Chem Lett. 2021 Feb 16;12(3):356-364. doi: 10.1021/acsmedchemlett.0c00311. PMID: 33738062; PMCID: PMC7957922.

Zhou CM, Wu Q, Wang B, Lin P, Wu M, Yu XJ. Calcium-responsive kinase LadS modulates type I-F CRISPR-Cas adaptive immunity. Biochem Biophys Res Commun. 2021 Mar 26;546:155-161. doi: 10.1016/j.bbrc.2021.01.100. Epub 2021 Feb 11. PMID: 33582559.

Walters DC, Lawrence R, Kirby T, Ahrendsen JT, Anderson MP, Roullet JB, Murphy EJ, Gibson KM; SSADH Deficiency Investigators Consortium (SDIC). Postmortem Analyses in a Patient With Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): II. Histological, Lipid, and Gene Expression Outcomes in Regional Brain Tissue. J Child Neurol. 2021 Feb 9:883073820987742. doi: 10.1177/0883073820987742. Epub ahead of print. PMID: 33557678

Halcrow PW, Geiger JD, Chen X. Overcoming Chemoresistance: Altering pH of Cellular Compartments by Chloroquine and Hydroxychloroquine. Front Cell Dev Biol. 2021 Feb 9;9:627639. doi: 10.3389/fcell.2021.627639. PMID: 33634129; PMCID: PMC7900406

Zhou CM, Wu Q, Wang B, Lin P, Wu M, Yu XJ. Calcium-responsive kinase LadS modulates type I-F CRISPR-Cas adaptive immunity. Biochem Biophys Res Commun. 2021 Feb 11;546:155-161. doi: 10.1016/j.bbrc.2021.01.100. Epub ahead of print. PMID: 33582559.

Walters DC, Lawrence R, Kirby T, Ahrendsen JT, Anderson MP, Roullet JB, Murphy EJ, Gibson KM; SSADH Deficiency Investigators Consortium (SDIC). Postmortem Analyses in a Patient With Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): II. Histological, Lipid, and Gene Expression Outcomes in Regional Brain Tissue. J Child Neurol. 2021 Feb 9:883073820987742. doi: 10.1177/0883073820987742. Epub ahead of print. PMID: 33557678.

Sahu B, Mackos AR, Floden AM, Wold LE, Combs CK. Particulate Matter Exposure Exacerbates Amyloid-β Plaque Deposition and Gliosis in APP/PS1 Mice. J Alzheimers Dis. 2021 Feb 4. doi: 10.3233/JAD-200919. Epub ahead of print. PMID: 33554902.

Casselli T, Divan A, Vomhof-DeKrey EE, Tourand Y, Pecoraro HL, Brissette CA. A murine model of Lyme disease demonstrates that Borrelia burgdorferi colonizes the dura mater and induces inflammation in the central nervous system. PLoS Pathog. 2021 Feb 1;17(2):e1009256. doi: 10.1371/journal.ppat.1009256. PMID: 33524035.

Chen F, Cheng X, Li J, Yuan X, Huang X, Lian M, Li W, Huang T, Xie Y, Liu J, Gao P, Wei X, Wang Z, Wu M. Novel Lytic Phages Protect Cells and Mice against Pseudomonas aeruginosa Infection. J Virol. 2021 Jan 20:JVI.01832-20. doi: 10.1128/JVI.01832-20. Epub ahead of print. PMID: 33472935.

Floden AM, Sohrabi M, Nookala S, Cao JJ, Combs CK. Salivary Aβ Secretion and Altered Oral Microbiome in Mouse Models of AD. Curr Alzheimer Res. 2021 Jan 19. doi: 10.2174/1567205018666210119151952. Epub ahead of print. PMID: 33463464.

Liu Y, Hur J, Chan WKB, Wang Z, Xie J, Sun D, Handelman S, Sexton J, Yu H, He Y. Ontological modeling and analysis of experimentally or clinically verified drugs against coronavirus infection. Sci Data. 2021 Jan 13;8(1):16. doi: 10.1038/s41597-021-00799-w. PMID: 33441564

Asali S, Raz A, Turki H, Mafakher L, Razmjou E, Solaymani-Mohammadi S. Restricted genetic heterogeneity of the Plasmodium vivax transmission-blocking vaccine (TBV) candidate Pvs48/45 in a low transmission setting: Implications for the Plasmodium vivax malaria vaccine development. Infect Genet Evol. 2021 Jan 6:104710. doi: 10.1016/j.meegid.2021.104710. Epub ahead of print. PMID: 33421653.

Sohrabi M, Pecoraro HL, Combs CK. Gut Inflammation Induced by Dextran Sulfate Sodium Exacerbates Amyloid-β Plaque Deposition in the AppNL - G - F Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2021 Jan 3. doi: 10.3233/JAD-201099. Epub ahead of print. PMID: 33427741.

Seeger DR, Golovko SA, Grove BD, Golovko MY. Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia. J Neurochem. 2021 Jan 2. doi: 10.1111/jnc.15291. Epub ahead of print. PMID: 33389746.

Schmit T, Klomp M, Khan MN. The Application of Flow Cytometry for Simultaneous and Multi-parametric Analysis of Heterogenous Cell Populations in Basic and Clinical Research. Methods Mol Biol. 2021;2223:183-200. doi: 10.1007/978-1-0716-1001-5_14. PMID: 33226596.

2020 Publications

Bordet G, Lodhi N, Guo D, Kossenkov A, Tulin AV. Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila. Sci Rep. 2020 Dec 3;10(1):21151. doi: 10.1038/s41598-020-78116-5. PMID: 33273587

Schmit T, Klomp M, Khan MN. An Overview of Flow Cytometry: Its Principles and Applications in Allergic Disease Research. Methods Mol Biol. 2021;2223:169-182. doi: 10.1007/978-1-0716-1001-5_13. PMID: 33226595.

Germundson DL, Nagamoto-Combs K. Isotype-Specific Detection of Serum Immunoglobulins Against Allergens. Methods Mol Biol. 2021;2223:159-167. doi: 10.1007/978-1-0716-1001-5_12. PMID: 33226594.

Smith NA, Nagamoto-Combs K. Induction of Hypersensitivity with Purified Beta-Lactoglobulin as a Mouse Model of Cow's Milk Allergy. Methods Mol Biol. 2021;2223:67-78. doi: 10.1007/978-1-0716-1001-5_5. PMID: 33226587.

Lin P, Wu Q, Wu M. Fossicking for microbial defense system: novel antiviral immunity. Signal Transduct Target Ther. 2020 Nov 27;5(1):281. doi: 10.1038/s41392-020-00423-0. PMID: 33247090.

Wang T, Qi Y, Wang Z, Zhao J, Ji L, Li J, Cai Z, Yang L, Wu M, Liang H. Coordinated regulation of anthranilate metabolism and bacterial virulence by the GntR family regulator MpaR in Pseudomonas aeruginosa. Mol Microbiol. 2020 Nov;114(5):857-869. doi: 10.1111/mmi.14584. Epub 2020 Aug 18. PMID: 32748556.

Zhou CM, Luo LM, Lin P, Pu Q, Wang B, Qin S, Wu Q, Yu XJ, Wu M. Annexin A2 regulates unfolded protein response via IRE1-XBP1 axis in macrophages during P. aeruginosa infection. J Leukoc Biol. 2020 Nov 22. doi: 10.1002/JLB.3A1219-686RR. Epub ahead of print. PMID: 33225536.

Cao Q, Yang N, Wang Y, Xu C, Zhang X, Fan K, Chen F, Liang H, Zhang Y, Deng X, Feng Y, Yang CG, Wu M, Bae T, Lan L. Mutation-induced remodeling of the BfmRS two-component system in Pseudomonas aeruginosa clinical isolates. Sci Signal. 2020 Nov 3;13(656):eaaz1529. doi: 10.1126/scisignal.aaz1529. PMID: 33144518.

Geiger JD, Khan N, Murugan M, Boison D. Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities. Front Pharmacol. 2020 Nov 26;11:594487. doi: 10.3389/fphar.2020.594487. PMID: 33324223

Bian G, Gu Y, Xu C, Yang W, Pan X, Chen Y, Lai M, Zhou Y, Dong Y, Mao B, Zhou Q, Chen B, Nakathata T, Shi L, Wu M, Zhang Y, Ma F. Early development and functional properties of tryptase/chymase double-positive mast cells from human pluripotent stem cells. J Mol Cell Biol. 2020 Oct 30:mjaa059. doi: 10.1093/jmcb/mjaa059. Epub ahead of print. PMID: 33125075.

Huang T, Pu Q, Zhou C, Lin P, Gao P, Zhang X, Chu Y, Yue B, Wu M. MicroRNA-302/367 Cluster Impacts Host Antimicrobial Defense via Regulation of Mitophagic Response Against Pseudomonas aeruginosa Infection. Front Immunol. 2020 Oct 7;11:569173. doi: 10.3389/fimmu.2020.569173. PMID: 33117356.

Nookala S, Krishnan KC, Mukundan S, Kotb M. Systems Genetics Approaches in Mouse Models of Group A Streptococcal Necrotizing Soft-Tissue Infections. Adv Exp Med Biol. 2020;1294:151-166. doi: 10.1007/978-3-030-57616-5_10. PMID: 33079368.

Murphy EJ, Chen GG. Randy Weselake: Celebrating a Gentleman Scholar Contributing across a Wide Spectrum of Lipid Biochemistry. Lipids. 2020 Sep;55(5):415-417. doi: 10.1002/lipd.12284. PMID: 33078887.

Hewlett E, Toma M, Sullivan-Reed K, Gordo J, Sliwinski T, Tulin A, Childers WE, Skorski T. Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia. Med Chem Res. 2020 Jun;29(6):962-978. doi: 10.1007/s00044-020-02537-0. Epub 2020 Apr 19. PMID: 33071527.

Zhang Y, Zhou CM, Pu Q, Wu Q, Tan S, Shao X, Zhang W, Xie Y, Li R, Yu XJ, Wang R, Zhang L, Wu M, Deng X. Correction for Zhang et al., "Pseudomonas aeruginosa Regulatory Protein AnvM Controls Pathogenicity in Anaerobic Environments and Impacts Host Defense". mBio. 2020 Oct 13;11(5):e02368-20. doi: 10.1128/mBio.02368-20. Erratum for: mBio. 2019 Jul 23;10(4): PMID: 33051369.

Germundson DL, Vendsel LP, Nagamoto-Combs K. Region-specific regulation of central histaminergic H3 receptor expression in a mouse model of cow's milk allergy. Brain Res. 2020 Dec 15;1749:147148. doi: 10.1016/j.brainres.2020.147148. Epub 2020 Oct 6. PMID: 33035498.

Kaur H, Singh Y, Singh S, Singh RB. Gut microbiome mediated epigenetic regulation of brain disorder and application of machine learning for multi-omics data analysis. Genome. 2020 Oct 8. doi: 10.1139/gen-2020-0136. Epub ahead of print. PMID: 33031715.

Al-Marsoummi S, Pacella J, Dockter K, Soderberg M, Singhal SK, Vomhof-DeKrey EE, Basson MD. Schlafen 12 Is Prognostically Favorable and Reduces C-Myc and Proliferation in Lung Adenocarcinoma but Not in Lung Squamous Cell Carcinoma. Cancers (Basel). 2020 Sep 24;12(10):E2738. doi: 10.3390/cancers12102738. PMID: 32987632.

O'Donnell KL, Espinosa DA, Puerta-Guardo H, Biering SB, Warnes CM, Schiltz J, Nilles ML, Li J, Harris E, Bradley DS. Avian anti-NS1 IgY antibodies neutralize dengue virus infection and protect against lethal dengue virus challenge. Antiviral Res. 2020 Sep 23;183:104923. doi: 10.1016/j.antiviral.2020.104923. Epub ahead of print. PMID: 32979401.

O'Donnell KL, Espinosa DA, Puerta-Guardo H, Biering SB, Warnes CM, Schiltz J, Nilles ML, Li J, Harris E, Bradley DS. Avian anti-NS1 IgY antibodies neutralize dengue virus infection and protect against lethal dengue virus challenge. Antiviral Res. 2020 Nov;183:104923. doi: 10.1016/j.antiviral.2020.104923. Epub 2020 Sep 23. PMID: 32979401.

Qin S, Lin P, Wu Q, Pu Q, Zhou C, Wang B, Gao P, Wang Z, Gao A, Overby M, Yang J, Jiang J, Wilson DL, Tahara YK, Kool ET, Xia Z, Wu M. Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection. J Immunol. 2020 Oct 15;205(8):2231-2242. doi: 10.4049/jimmunol.1901533. Epub 2020 Sep 14. PMID: 32929043

Won S, Cho YJ, Lee N, Kim M, Kim MK, Jung YW, Yun BS, Seong SJ, Hur J, Kim ML. Atypical endometriosis is related to a higher recurrence rate. Eur J Obstet Gynecol Reprod Biol. 2020 Nov;254:44-51. doi: 10.1016/j.ejogrb.2020.08.054. Epub 2020 Sep 6. PMID: 32920422.

Shao X, Xie Y, Zhang Y, Liu J, Ding Y, Wu M, Wang X, Deng X. Novel therapeutic strategies for treating Pseudomonas aeruginosa infection. Expert Opin Drug Discov. 2020 Sep 3:1-21. doi: 10.1080/17460441.2020.1803274. Epub ahead of print. PMID: 32880507.

Klomp M, Ghosh S, Mohammed S, Nadeem Khan M. From virus to inflammation, how influenza promotes lung damage. J Leukoc Biol. 2020 Sep 8. doi: 10.1002/JLB.4RU0820-232R. Epub ahead of print. PMID: 32895987.

Shin D, Lee KJ, Adeluwa T, Hur J. Machine Learning-Based Predictive Modeling of Postpartum Depression. J Clin Med. 2020 Sep 8;9(9):E2899. doi: 10.3390/jcm9092899. PMID: 32911726.

Goutman SA, Boss J, Guo K, Alakwaa FM, Patterson A, Kim S, Savelieff MG, Hur J, Feldman EL. Untargeted metabolomics yields insight into ALS disease mechanisms. J Neurol Neurosurg Psychiatry. 2020 Sep 14:jnnp-2020-323611. doi: 10.1136/jnnp-2020-323611.  PMID: 32928939.

Qin S, Lin P, Wu Q, Pu Q, Zhou C, Wang B, Gao P, Wang Z, Gao A, Overby M, Yang J, Jiang J, Wilson DL, Tahara YK, Kool ET, Xia Z, Wu M. Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection. J Immunol. 2020 Sep 14:ji1901533. doi: 10.4049/jimmunol.1901533. Epub ahead of print. PMID: 32929043.

O'Donnell KL, Espinosa DA, Puerta-Guardo H, Biering SB, Schiltz J, Nilles ML, Li J, Harris E, Bradley DS. Avian anti-NS1 IgY antibodies neutralize dengue virus infection and protect against lethal dengue virus challenge. Antiviral Res. 2020 Sep 23:104923. doi: 10.1016/j.antiviral.2020.104923. Epub ahead of print. PMID: 32979401

Al-Marsoummi S, Pacella J, Dockter K, Soderberg M, Singhal SK, Vomhof-DeKrey EE, Basson MD. Schlafen 12 Is Prognostically Favorable and Reduces C-Myc and Proliferation in Lung Adenocarcinoma but Not in Lung Squamous Cell Carcinoma. Cancers (Basel). 2020 Sep 24;12(10):E2738. doi: 10.3390/cancers12102738. PMID: 32987632.

Jurivich DA, Manocha GD, Trivedi R, Lizakowski M, Rakoczy S, Brown-Borg H. Multifactorial Attenuation of the Murine Heat Shock Response With Age. J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1846-1852. doi: 10.1093/gerona/glz204. PMID: 31612204

Qin S, Pu Q, Wang Z, Wu M. Apolipoprotein E in Asthmatic Inflammatory Response: Friend or Foe? Am J Respir Cell Mol Biol. 2020 Aug;63(2):141-143. doi: 10.1165/rcmb.2020-0106ED. PMID: 32383998

Lin P, Qin S, Pu Q, Wang Z, Wu Q, Gao P, Schettler J, Guo K, Li R, Li G, Huang C, Wei Y, Gao GF, Jiang J, Wu M. CRISPR-Cas13 Inhibitors Block RNA Editing in Bacteria and Mammalian Cells. Mol Cell. 2020 Jun 4;78(5):850-861.e5. doi: 10.1016/j.molcel.2020.03.033. Epub 2020 Apr 28. PMID: 32348779

Wang Q, Peng H, Qi X, Wu M, Zhao X. Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence. Signal Transduct Target Ther. 2020 Jul 29;5(1):137. doi: 10.1038/s41392-020-0199-6. PMID: 32728057

Qin S, Pu Q, Wang Z, Wu M. Apolipoprotein E in Asthmatic Inflammatory Response: Friend or Foe? Am J Respir Cell Mol Biol. 2020 Aug;63(2):141-143. doi: 10.1165/rcmb.2020-0106ED. PMID: 32383998

Zhu P, Bu H, Tan S, Liu J, Yuan B, Dong G, Wang M, Jiang Y, Zhu H, Li H, Li Z, Jiang J, Wu M, Li R. A Novel Cochlioquinone Derivative, CoB1, Regulates Autophagy in Pseudomonas aeruginosa Infection through the PAK1/Akt1/mTOR Signaling Pathway. J Immunol. 2020 Sep 1;205(5):1293-1305. doi: 10.4049/jimmunol.1901346. Epub 2020 Aug 3. PMID: 32747503.

Gao P, Guo K, Pu Q, Wang Z, Lin P, Qin S, Khan N, Hur J, Liang H, Wu M. oprC Impairs Host Defense by Increasing the Quorum-Sensing-Mediated Virulence of Pseudomonas aeruginosa. Front Immunol. 2020 Aug 4;11:1696. doi: 10.3389/fimmu.2020.01696. PMID: 32849593

Brown-Borg HM, Borg KE. A summary of the Proceedings of the Fourteenth International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 15-20, 2018. Geroscience. 2020 Aug 11. doi: 10.1007/s11357-020-00234-9. Epub ahead of print. PMID: 32780291

Petry NJ, Montgomery AD, Hammer KDP, Lo TS. Methicillin-resistant Staphylococcus aureus (MRSA) screening upon inpatient hospital admission: Is there concordance between nasal swab results and samples taken from skin and soft tissue? Infect Control Hosp Epidemiol. 2020 Aug 12:1-4. doi: 10.1017/ice.2020.345. Epub ahead of print. PMID: 32782054.

Guo K, Eid SA, Elzinga SE, Pacut C, Feldman EL, Hur J. Genome-wide profiling of DNA methylation and gene expression identifies candidate genes for human diabetic neuropathy. Clin Epigenetics. 2020 Aug 12;12(1):123. doi: 10.1186/s13148-020-00913-6. Erratum in: Clin Epigenetics. 2020 Aug 27;12(1):130. PMID: 32787975

Tanaka H, Takizawa Y, Takaku M, Kato D, Kumagawa Y, Grimm SA, Wade PA, Kurumizaka H. Interaction of the pioneer transcription factor GATA3 with nucleosomes. Nat Commun. 2020 Aug 18;11(1):4136. doi: 10.1038/s41467-020-17959-y. PMID: 32811816

Wang Z, Zhang L, Wu M. Human-viral chimera: a novel protein affecting viral virulence and driving host T-cell immunity. Signal Transduct Target Ther. 2020 Aug 25;5(1):167. doi: 10.1038/s41392-020-00272-x. PMID: 32843627

Guo K, Eid SA, Elzinga SE, Pacut C, Feldman EL, Hur J. Correction to: Genome-wide profiling of DNA methylation and gene expression identifies candidate genes for human diabetic neuropathy. Clin Epigenetics. 2020 Aug 27;12(1):130. doi: 10.1186/s13148-020-00922-5. Erratum for: Clin Epigenetics. 2020 Aug 12;12(1):123. PMID: 32854766

Milavetz B, Haugen J, Rowbotham K. Comparing a new method for mapping nucleosomes in simian virus 40 chromatin to standard procedures. Epigenetics. 2020 Aug 30:1-10. doi: 10.1080/15592294.2020.1814487. Epub ahead of print. PMID: 32838633

Qin S, Pu Q, Wang Z, Wu M. Apolipoprotein E in Asthmatic Inflammatory Response: Friend or Foe? Am J Respir Cell Mol Biol. 2020 Aug;63(2):141-143. doi: 10.1165/rcmb.2020-0106ED. PMID: 32383998

Hostetter J, Schwarz N, Klug M, Wynne J, Basson MD. Primary care visits increase utilization of evidence-based preventative health measures. BMC Fam Pract. 2020 Jul 28;21(1):151. doi: 10.1186/s12875-020-01216-8. PMID: 32718313

Haage A, Wagner K, Deng W, Venkatesh B, Mitchell C, Goodwin K, Bogutz A, Lefebvre L, Van Raamsdonk CD, Tanentzapf G. Precise coordination of cell-ECM adhesion is essential for efficient melanoblast migration during development. Development. 2020 Jul 17;147(14):dev184234. doi: 10.1242/dev.184234. PMID: 32580934

Thompson D, Sorenson J, Greenmyer J, Brissette CA, Watt JA. The Lyme disease bacterium, Borrelia burgdorferi, stimulates an inflammatory response in human choroid plexus epithelial cells. PLoS One. 2020 Jul 9;15(7):e0234993. doi: 10.1371/journal.pone.0234993. PMID: 32645014

Sohrabi M, Floden AM, Manocha GD, Klug MG, Combs CK. IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer's Disease Transgenic Mouse Model. Front Cell Neurosci. 2020 Jul 3;14:200. doi: 10.3389/fncel.2020.00200. PMID: 32719587

Chen X, Geiger JD. Janus sword actions of chloroquine and hydroxychloroquine against COVID-19. Cell Signal. 2020 Sep;73:109706. doi: 10.1016/j.cellsig.2020.109706. Epub 2020 Jul 3. PMID: 32629149

Schmit T, Ghosh S, Mathur RK, Barnhardt T, Ambigapathy G, Wu M, Combs C, Khan MN. IL-6 Deficiency Exacerbates Allergic Asthma and Abrogates the Protective Effect of Allergic Inflammation against Streptococcus pneumoniae Pathogenesis. J Immunol. 2020 Jul 15;205(2):469-479. doi: 10.4049/jimmunol.1900755. Epub 2020 Jun 15. PMID: 32540994

He Y, Yu H, Ong E, Wang Y, Liu Y, Huffman A, Huang HH, Beverley J, Hur J, Yang X, Chen L, Omenn GS, Athey B, Smith B. CIDO, a community-based ontology for coronavirus disease knowledge and data integration, sharing, and analysis. Sci Data. 2020 Jun 12;7(1):181. doi: 10.1038/s41597-020-0523-6. PMID: 32533075

Fernandes JD, Sarabipour S, Smith CT, Niemi NM, Jadavji NM, Kozik AJ, Holehouse AS, Pejaver V, Symmons O, Bisson Filho AW, Haage A. A survey-based analysis of the academic job market. Elife. 2020 Jun 12;9:e54097. doi: 10.7554/eLife.54097. PMID: 32530420

Xu H, Xiang M, Qin Y, Cheng H, Chen D, Fu Q, Zhang KK, Xie L. Tbx5 inhibits hedgehog signaling in determination of digit identity. Hum Mol Genet. 2020 Jun 3;29(9):1405-1416. doi: 10.1093/hmg/ddz185. PMID: 31373354

In Vivo Generation of PFOA, PFOS, and Other Compounds from Cationic and Zwitterionic Per- and Polyfluoroalkyl Substances in a Terrestrial Invertebrate (Lumbricus terrestris). Jin B, Mallula S, Golovko SA, Golovko MY, Xiao F. Environ Sci Technol. 2020 Jun 16;54(12):7378-7387. doi: 10.1021/acs.est.0c01644. Epub 2020 Jun 1. PMID: 32479721

miR-410 induces both epithelial-mesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer. Yuan Y, Liao H, Pu Q, Ke X, Hu X, Ma Y, Luo X, Jiang Q, Gong Y, Wu M, Liu L, Zhu W. Signal Transduct Target Ther. 2020 Jun 12;5(1):85. doi: 10.1038/s41392-020-0182-2. PMID: 32528035

A survey-based analysis of the academic job market. Fernandes JD, Sarabipour S, Smith CT, Niemi NM, Jadavji NM, Kozik AJ, Holehouse AS, Pejaver V, Symmons O, Bisson Filho AW, Haage A. Elife. 2020 Jun 12;9:e54097. doi: 10.7554/eLife.54097. Online ahead of print. PMID: 32530420

Medical resources are scarce, but theories about their allocation are not. Basson MD. Surgery. 2020 May 8:S0039-6060(20)30255-5. doi: 10.1016/j.surg.2020.05.001. Online ahead of print. PMID: 32532467

Temporal Trends in 6-minute Walking Distance for Older Japanese Adults Between 1998 and 2017. Tomkinson GR, Kidokoro T, Dufner T, Noi S, Fitzgerald JS, Brown-Borg HM. J Sport Health Sci. 2020 Jun 15:S2095-2546(20)30073-9. doi: 10.1016/j.jshs.2020.06.007. Online ahead of print. PMID: 32553730

Precise coordination of cell-ECM adhesion is essential for efficient melanoblast migration during development.
Haage A, Wagner K, Deng W, Venkatesh B, Mitchell C, Goodwin K, Bogutz A, Lefebvre L, Van Raamsdonk CD, Tanentzapf G. Development. 2020 Jun 24:dev.184234. doi: 10.1242/dev.184234. Online ahead of print. PMID: 32580934

In Vivo Generation of PFOA, PFOS, and Other Compounds from Cationic and Zwitterionic Per- and Polyfluoroalkyl Substances in a Terrestrial Invertebrate (Lumbricus terrestris). Jin B, Mallula S, Golovko SA, Golovko MY, Xiao F. Environ Sci Technol. 2020 Jun 1. doi: 10.1021/acs.est.0c01644. Online ahead of print. PMID: 32479721

Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis. Paez-Colasante X, Figueroa-Romero C, Rumora AE, Hur J, Mendelson FE, Hayes JM, Backus C, Taubman GF, Heinicke L, Walter NG, Barmada SJ, Sakowski SA, Feldman EL. Front Cell Neurosci. 2020 May 12;14:117. doi: 10.3389/fncel.2020.00117. eCollection 2020. PMID: 32477070

Oxytocin receptors excite lateral nucleus of central amygdala by PLCβ and PKC-dependent depression of inwardly rectifying K+ channels. Hu B, Boyle CA, Lei S. J Physiol. 2020 May 27. doi: 10.1113/JP279457. Online ahead of print. PMID: 32458437

Decrease in alpha-1 antiproteinase antitrypsin is observed in primary Sjogren's syndrome condition.
Singh BB, Ohm J, Quenum Zanbede FO, Chauhan P, Kroese FGM, Vissink A, Ambrus JL, Mishra BB. Autoimmunity. 2020 May 25:1-13. doi: 10.1080/08916934.2020.1768376. Online ahead of print. PMID: 32449389

Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer's disease. Kaur H, Nagamoto-Combs K, Golovko S, Golovko MY, Klug MG, Combs CK. Neurobiol Aging. 2020 Aug;92:114-134. doi: 10.1016/j.neurobiolaging.2020.04.009. Epub 2020 Apr 18. PMID: 32417748

Histone-dependent PARP-1 inhibitors: A novel therapeutic modality for the treatment of prostate and renal cancers. Makhov P, Uzzo RG, Tulin AV, Kolenko VM. Urol Oncol. 2020 May 8:S1078-1439(20)30145-9. doi: 10.1016/j.urolonc.2020.04.004. Online ahead of print. PMID: 32402770

APOE in Asthmatic Inflammatory Response: Friend or Foe? Qin S, Pu Q, Wang Z, Wu M. Am J Respir Cell Mol Biol. 2020 May 8. doi: 10.1165/rcmb.2020-0106ED. Online ahead of print. PMID: 32383998

Sustained research fund and dedicated research center for preparing next pandemic. Jia H, Wu M. Precis Clin Med. 2020;pbaa012. Published 2020 Apr 11. doi:10.1093/pcmedi/pbaa012. PMCID: PMC7184470

Structurally unique PARP‐1 inhibitors for the treatment of prostate cancer. Divan A, Sibi MP, Tulin A.Structurally unique PARP-1 inhibitors for the treatment of prostate cancer. Pharmacol Res Perspect. 2020;8(2):e00586. doi:10.1002/prp2.586 PMID: 32342655

Cancer-specific mutation of GATA3 disrupts the transcriptional regulatory network governed by Estrogen Receptor alpha, FOXA1 and GATA3. Takaku M, Grimm SA, De Kumar B, Bennett BD, Wade PA. Nucleic Acids Res. 2020 Mar 30. pii: gkaa179. doi: 10.1093/nar/gkaa179. [Epub ahead of print] PMID: 32232341

Exploring histone loading on HIV DNA reveals a dynamic nucleosome positioning between unintegrated and integrated viral genome. Machida S, Depierre D, Chen HC, Thenin-Houssier S, Petitjean G, Doyen CM, Takaku M, Cuvier O, Benkirane M. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6822-6830. doi: 10.1073/pnas.1913754117. Epub 2020 Mar 11. PMID: 32161134

Probing Pedomorphy and Prolonged Lifespan in Naked Mole-Rats and Dwarf Mice. Buffenstein R, Lewis KN, Gibney PA, Narayan V, Grimes KM, Smith M, Lin TD, Brown-Borg HM. Physiology (Bethesda). 2020 Mar 1;35(2):96-111. doi: 10.1152/physiol.00032.2019 PMID: 32024425

Two-pore channels regulate Tat endolysosome escape and Tat-mediated HIV-1 LTR transactivation. Khan N, Halcrow PW, Lakpa KL, Afghah Z, Miller NM, Dowdy SF, Geiger JD, Chen X. FASEB J. 2020  Mar;34(3):4147-4162. doi: 10.1096/fj.201902534R. Epub 2020 Jan 16. PMID: 31950548

Old neurochemical markers, new functional directions?: An Editorial for 'Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain' on page 650. De Deurwaerdere P, Gaetani S, Vaughan RA. J Neurochem. 2020 Mar;152(6):623-626. doi: 10.1111/jnc.14929. Epub 2020 Jan 9. PMID: 31917872

Difference in Strain Pathogenicity of Septicemic Yersinia pestis Infection in a TLR2-/- Mouse Model. O'Donnell KL, Knopick PL, Larsen R, Sarkar S, Nilles ML, Bradley DS. Infect Immun. 2020 Feb 20;88(3). pii: e00792-19. doi: 10.1128/IAI.00792-19. Print 2020 Feb 20. PMID: 31907194

Taurine treatment of retinal degeneration and cardiomyopathy in a consanguineous family with SLC6A6 taurine transporter deficiency. Ansar M, Ranza E, Shetty M, Paracha SA, Azam M, Kern I, Iwaszkiewicz J, Farooq O, Pournaras CJ, Malcles A, Kecik M, Rivolta C, Muzaffar W, Qurban A, Ali L, Aggoun Y, Santoni FA, Makrythanasis P, Ahmed J, Qamar R, Sarwar MT, Henry LK, Antonarakis SE. Hum Mol Genet. 2020 Mar 13;29(4):618-623. doi: 10.1093/hmg/ddz303. PMID: 31903486

COX-2-derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease. Rangarajan S, Rezonzew G, Chumley P, Fatima H, Golovko MY, Feng W, Hua P, Jaimes EA. Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F475-F485. doi: 10.1152/ajprenal.00407.2019. Epub 2019 Dec 16. PMID: 31841390

Role of endolysosomes and inter-organellar signaling in brain disease. Afghah Z, Chen X, Geiger JD. Neurobiol Dis. 2020 Feb;134:104670. doi: 10.1016/j.nbd.2019.104670. Epub 2019 Nov 9. Review. PMID: 31707116

Better Quality Metrics Could Illuminate Quality-Efficiency Tradeoffs in Operating Room Management. Basson MD. J Invest Surg. 2020 Mar;33(3):271-272. doi: 10.1080/08941939.2018.1493552. Epub 2018 Oct 31. PMID: 30380345

Loss of Schlafen3 influences the expression levels of Schlafen family members in ileum, thymus, and spleen tissue. Vomhof-DeKrey EE, Umthun J, Basson MD. PeerJ. 2020 Jan 28;8:e8461. doi: 10.7717/peerj.8461. eCollection 2020. PMID: 32025381

Targeting folate receptor β positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex. Tie Y, Zheng H, He Z, Yang J, Shao B, Liu L, Luo M, Yuan X, Liu Y, Zhang X, Li H, Wu M, Wei X. Signal Transduct Target Ther. 2020 Jan 22;5:6. doi: 10.1038/s41392-020-0115-0. eCollection 2020. PMID: 31993222

My Tenure as Editor-in-Chief of Lipids: What I Learned. Murphy EJ. Lipids. 2020 Jan;55(1):3-4. doi:  10.1002/lipd.12215. No abstract available. PMID: 31989666

Impact Factor vs Integrity Factor: Which Siren Should Be Our Guide? Murphy EJ. Lipids. 2020 Jan;55(1):5-6. doi: 10.1002/lipd.12214. No abstract available. PMID: 31989665

"A Glance Back" at the Journals of Gerontology: We've Come a Long Way, Baby! Brown-Borg HM. J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):205-206. doi: 10.1093/gerona/glz170. No abstract available. PMID: 31957811

Two-pore channels regulate Tat endolysosome escape and Tat-mediated HIV-1 LTR transactivation. Khan N, Halcrow PW, Lakpa KL, Afghah Z, Miller NM, Dowdy SF, Geiger JD, Chen X. FASEB J. 2020 Jan 16. doi: 10.1096/fj.201902534R. [Epub ahead of print] PMID: 31950548

CRISPR-cas3 of Salmonella Upregulates Bacterial Biofilm Formation and Virulence to Host Cells by Targeting Quorum-Sensing Systems. Cui L, Wang X, Huang D, Zhao Y, Feng J, Lu Q, Pu Q, Wang Y, Cheng G, Wu M, Dai M. Pathogens. 2020 Jan 10;9(1). pii: E53. doi: 10.3390/pathogens9010053. PMID: 31936769

Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects. Li H, Yang Y, Hong W, Huang M, Wu M, Zhao X. Signal Transduct Target Ther. 2020 Jan 3;5:1. doi: 10.1038/s41392-019-0089-y. eCollection 2020. Review. PMID: 31934359

Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1? Deme P, Rojas C, Slusher BS, Afghah Z, Geiger JD, Haughey NJ. Exp Neurol. 2020 Jan 10:113181. doi: 10.1016/j.expneurol.2020.113181. [Epub ahead of print] Review. PMID: 31930991

Old neurochemical markers, new functional directions?: An Editorial for 'Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain' on doi: 10.1111/jnc.14897. De Deurwaerdere P, Gaetani S, Vaughan RA. J Neurochem. 2020 Jan 9:e14929. doi: 10.1111/jnc.14929. [Epub ahead of print] PMID: 31917872

Difference in strain pathogenicity of a septicemic Yersinia pestis infection in a TLR2-/- mouse model. O'Donnell KL, Knopick PL, Larsen R, Sarkar S, Nilles ML, Bradley DS. Infect Immun. 2020 Jan 6. pii: IAI.00792-19. doi: 10.1128/IAI.00792-19. [Epub ahead of print] PMID: 31907194

Blood-Brain Barrier Is the Major Site for a Rapid and Dramatic Prostanoid Increase upon Brain Global Ischemia. Seeger DR, Golovko SA, Golovko MY. Lipids. 2020 Jan;55(1):79-85. doi: 10.1002/lipd.12205. Epub 2019 Dec 8.
PMID: 31814137

Circulating levels of ATP is a biomarker of HIV cognitive impairment. Velasquez S, Prevedel L, Valdebenito S, Gorska AM, Golovko M, Khan N, Geiger J, Eugenin EA. EBioMedicine. 2020 Jan;51:102503. doi: 10.1016/j.ebiom.2019.10.029. Epub 2019 Dec 3. PMID: 31806564

Enhanced synergetic antibacterial activity by a reduce graphene oxide/Ag nanocomposite through the photothermal effect. Tan S, Wu X, Xing Y, Lilak S, Wu M, Zhao JX. Colloids Surf B Biointerfaces. 2020 Jan 1;185:110616. doi: 10.1016/j.colsurfb.2019.110616. Epub 2019 Nov 5. PMID: 31740323

Readily Releasable Stores of Calcium in Neuronal Endolysosomes: Physiological and Pathophysiological Relevance. Lakpa KL, Halcrow PW, Chen X, Geiger JD. Adv Exp Med Biol. 2020;1131:681-697. doi: 10.1007/978-3-030-12457-1_27. Review. PMID: 31646530

2019 Publications

Taurine treatment of retinal degeneration and cardiomyopathy in a consanguineous family with SLC6A6 taurine transporter deficiency. Ansar M, Ranza E, Shetty M, Paracha SA, Azam M, Kern I, Iwaszkiewicz J, Farooq O, Pournaras CJ, Malcles A, Kecik M, Rivolta C, Muzaffar W, Qurban A, Ali L, Aggoun Y, Santoni FA, Makrythanasis P, Ahmed J, Qamar R, Sarwar MT, Henry LK, Antonarakis SE.  Hum Mol Genet [Internet]. 2019 Dec 31;

Prolonged Amphetamine Treatments Cause Long-Term Decrease of Dopamine Uptake in Cultured Cells. Ferdous N, Kudumala S, Sossi S, Carvelli L. Neurochem Res. 2019 Dec 27. doi: 10.1007/s11064-019-02938-7. [Epub ahead of print] PMID: 31883055

A 2018 workshop: vaccine and drug ontology studies (VDOS 2018). Hur J, Tao C, He Y. BMC Bioinformatics. 2019 Dec 23;20(Suppl 21):705. doi: 10.1186/s12859-019-3191-9. PMID: 31865905

Machine learning-based identification and rule-based normalization of adverse drug reactions in drug labels. Tiftikci M, Özgür A, He Y, Hur J. BMC Bioinformatics. 2019 Dec 23;20(Suppl 21):707. doi:  10.1186/s12859-019-3195-5. PMID: 31865904

Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes. O'Brien PD, Guo K, Eid SA, Rumora AE, Hinder LM, Hayes JM, Mendelson FE, Hur J, Feldman EL. Dis Model Mech. 2019 Dec 10. pii: dmm.042101. doi: 10.1242/dmm.042101. [Epub ahead of print] PMID: 31822493

Blood-Brain Barrier Is the Major Site for a Rapid and Dramatic Prostanoid Increase upon Brain Global Ischemia. Seeger DR, Golovko SA, Golovko MY. Lipids. 2019 Dec 8. doi: 10.1002/lipd.12205. [Epub ahead of print] PMID: 31814137

Circulating levels of ATP is a biomarker of HIV cognitive impairment. Velasquez S, Prevedel L, Valdebenito S, Gorska AM, Golovko M, Khan N, Geiger J, Eugenin EA. EBioMedicine. 2019 Dec 2. pii: S2352-3964(19)30692-9. doi: 10.1016/j.ebiom.2019.10.029. [Epub ahead of print] PMID: 31806564

A network of phosphatidylinositol (4,5)-bisphosphate (PIP2) binding sites on the dopamine transporter regulates amphetamine behavior in Drosophila Melanogaster. Belovich AN, Aguilar JI, Mabry SJ, Cheng MH, Zanella D, Hamilton PJ, Stanislowski DJ, Shekar A, Foster JD, Bahar I, Matthies HJG, Galli A. Mol Psychiatry. 2019 Dec 3. doi: 10.1038/s41380-019-0620-0. [Epub ahead of print] PMID: 31796894

The potential role of necroptosis in inflammaging and aging. Royce GH, Brown-Borg HM, Deepa SS. Geroscience. 2019 Dec;41(6):795-811. doi: 10.1007/s11357-019-00131-w. Epub 2019 Nov 13. Review. PMID: 31721033

Protease Inhibitors, Saquinavir and Darunavir, Inhibit Oligodendrocyte Maturation: Implications for Lysosomal Stress. Festa L, Roth LM, K Jensen B, Geiger JD, Jordan-Sciutto KL, Grinspan JB. J Neuroimmune Pharmacol. 2019 Nov 28. doi: 10.1007/s11481-019-09893-8. [Epub ahead of print] PMID: 31776836

Maternal diet intervention before pregnancy primes offspring lipid metabolism in liver. Zhou Y, Peng H, Xu H, Li J, Golovko M, Cheng H, Lynch EC, Liu L, McCauley N, Kennedy L, Alpini G, Zhang KK, Xie L. Lab Invest. 2019 Nov 20. doi: 10.1038/s41374-019-0344-4. [Epub ahead of print] PMID: 31748681

Enhanced synergetic antibacterial activity by a reduce graphene oxide/Ag nanocomposite through the photothermal effect. Tan S, Wu X, Xing Y, Lilak S, Wu M, Zhao JX. Colloids Surf B Biointerfaces. 2019 Nov 5:110616. doi: 10.1016/j.colsurfb.2019.110616. [Epub ahead of print] PMID: 31740323

The potential role of necroptosis in inflammaging and aging. Royce GH, Brown-Borg HM, Deepa SS.
Geroscience. 2019 Nov 13. doi: 10.1007/s11357-019-00131-w. [Epub ahead of print] Review. PMID: 31721033

Role of endolysosomes and inter-organellar signaling in brain disease. Afghah Z, Chen X, Geiger JD. Neurobiol Dis. 2019 Nov 9;134:104670. doi: 10.1016/j.nbd.2019.104670. [Epub ahead of print] Review. PMID: 31707116

Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice.
Figueroa-Romero C, Guo K, Murdock BJ, Paez-Colasante X, Bassis CM, Mikhail KA, Raue KD, Evans MC, Taubman GF, McDermott AJ, O'Brien PD, Savelieff MG, Hur J, Feldman EL. Dis Model Mech. 2019 Nov 15;13(2). pii: dmm041947. doi: 10.1242/dmm.041947. PMID: 31597644

Bacterial Type I CRISPR-Cas systems influence inflammasome activation in mammalian host by promoting autophagy. Wu Q, Wang B, Zhou C, Lin P, Qin S, Gao P, Wang Z, Xia Z, Wu M. Immunology. 2019 Nov;158(3):240-251. doi: 10.1111/imm.13108. Epub 2019 Sep 17. PMID: 31429483

Involvement of organelles and inter-organellar signaling in the pathogenesis of HIV-1 associated neurocognitive disorder and Alzheimer's disease. Khan N, Haughey NJ, Nath A, Geiger JD. Brain Res. 2019 Nov 1;1722:146389. doi: 10.1016/j.brainres.2019.146389. Epub 2019 Aug 16. Review. PMID: 31425679

Multifactorial Attenuation of the Murine Heat Shock Response With Age. Jurivich DA, Manocha GD, Trivedi R, Lizakowski M, Rakoczy S, Brown-Borg H. J Gerontol A Biol Sci Med Sci. 2019 Oct 14. pii: glz204. doi: 10.1093/gerona/glz204. [Epub ahead of print] PMID: 31612204

Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing. Wang Q, More SK, Vomhof-DeKrey EE, Golovko MY, Basson MD. Sci Rep. 2019 Oct 11;9(1):14669. doi: 10.1038/s41598-019-51183-z. PMID:31604999

Interaction among inflammasome, autophagy and non-coding RNAs: new horizons for drug. Pu Q, Lin P, Wang Z, Gao P, Qin S, Cui L, Wu M. Precis Clin Med. 2019 Sep;2(3):166-182. doi: 10.1093/pcmedi/pbz019. Epub 2019 Oct 1. Review. PMID: 31598387

Temporal evolution of the microbiome, immune system, and epigenome with disease progression in ALS mice. Figueroa-Romero C, Guo K, Murdock BJ, Paez-Colasante X, Bassis CM, Mikhail KA, Raue KD, Evans MC, Taubman GF, McDermott AJ, O'Brien PD, Savelieff MG, Hur J, Feldman EL. Dis Model Mech. 2019 Oct 9. pii: dmm.041947. doi: 10.1242/dmm.041947. [Epub ahead of print] PMID: 31597644

Sorption and Desorption Mechanisms of Cationic and Zwitterionic Per- and Polyfluoroalkyl Substances in Natural Soils: Thermodynamics and Hysteresis. Xiao F, Jin B, Golovko SA, Golovko MY, Xing B. Environ Sci Technol. 2019 Oct 15;53(20):11818-11827. doi: 10.1021/acs.est.9b05379. Epub 2019 Sep 25. PMID: 31553179

Sterol Carrier Protein-2/Sterol Carrier Protein-x/Fatty Acid Binding Protein-1 Ablation Impacts Response of Brain Endocannabinoid to High-Fat Diet. Martin GG, Seeger DR, McIntosh AL, Milligan S, Chung S, Landrock D, Dangott LJ, Golovko MY, Murphy EJ, Kier AB, Schroeder F. Lipids. 2019 Oct;54(10):583-601. doi: 10.1002/lipd.12192. Epub 2019 Sep 5. PMID: 31487051

Toll-like receptors and inflammation in metabolic neuropathy; a role in early versus late disease? Elzinga S, Murdock BJ, Guo K, Hayes JM, Tabbey MA, Hur J, Feldman EL. Exp Neurol. 2019 Oct;320:112967. doi: 10.1016/j.expneurol.2019.112967. Epub 2019 May 28. PMID: 31145897

Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha. Askvig JM, Watt JA. J Comp Neurol. 2019 Oct 1;527(14):2291-2301. doi: 10.1002/cne.24675. Epub 2019 Mar 25. PMID: 30861131

Sorption and Desorption Mechanisms of Cationic and Zwitterionic Per- and Polyfluoroalkyl Substances in Natural Soils: Thermodynamics and Hysteresis. Xiao F, Jin B, Golovko SA, Golovko MY, Xing B. Environ Sci Technol. 2019 Sep 25. doi: 10.1021/acs.est.9b05379. [Epub ahead of print] PMID: 31553179

Sterol Carrier Protein-2/Sterol Carrier Protein-x/Fatty Acid Binding Protein-1 Ablation Impacts Response of Brain Endocannabinoid to High-Fat Diet. Martin GG, Seeger DR, McIntosh AL, Milligan S, Chung S, Landrock D, Dangott LJ, Golovko MY, Murphy EJ, Kier AB, Schroeder F. Lipids. 2019 Sep 5. doi: 10.1002/lipd.12192. [Epub ahead of print] PMID: 31487051

Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice. Manocha GD, Floden AM, Miller NM, Smith AJ, Nagamoto-Combs K, Saito T, Saido TC, Combs CK. Neurobiol Aging. 2019 Sep;81:166-176. doi: 10.1016/j.neurobiolaging.2019.05.025. Epub 2019 Jun 13. PMID: 31284126

The Lyme disease spirochete's BpuR DNA/RNA-binding protein is differentially expressed during the mammal-tick infectious cycle, which affects translation of the SodA superoxide dismutase. Jutras BL, Savage CR, Arnold WK, Lethbridge KG, Carroll DW, Tilly K, Bestor A, Zhu H, Seshu J, Zückert WR, Stewart PE, Rosa PA, Brissette CA, Stevenson B. Mol Microbiol. 2019 Sep;112(3):973-991. doi: 10.1111/mmi.14336. Epub 2019 Jul 7. PMID: 31240776

Microenvironment-sensing, nanocarrier-mediated delivery of combination chemotherapy for pancreatic cancer. Ray P, Nair G, Ghosh A, Banerjee S, Golovko MY, Banerjee SK, Reindl KM, Mallik S, Quadir M. J Cell Commun Signal. 2019 Sep;13(3):407-420. doi: 10.1007/s12079-019-00514-w. Epub 2019 Mar 26. PMID: 30915617

BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation. Khan N, Lakpa KL, Halcrow PW, Afghah Z, Miller NM, Geiger JD, Chen X. Sci Rep. 2019 Aug 22;9(1):12285. doi: 10.1038/s41598-019-48777-y.
PMID: 31439883

Bacterial Type I CRISPR-Cas systems influence inflammasome activation in mammalian host by promoting autophagy. Wu Q, Wang B, Zhou C, Lin P, Qin S, Gao P, Wang Z, Xia Z, Wu M. Immunology. 2019 Aug 20. doi: 10.1111/imm.13108. [Epub ahead of print] PMID: 31429483

High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination. Lin P, Pu Q, Wu Q, Zhou C, Wang B, Schettler J, Wang Z, Qin S, Gao P, Li R, Li G, Cheng Z, Lan L, Jiang J, Wu M. Nat Commun. 2019 Aug 19;10(1):3728. doi: 10.1038/s41467-019-11695-8. PMID: 31427601

Involvement of organelles and inter-organellar signaling in the pathogenesis of HIV-1 associated neurocognitive disorder and Alzheimer's disease. Khan N, Haughey NJ, Nath A, Geiger JD. Brain Res. 2019 Aug 16;1722:146389. doi: 10.1016/j.brainres.2019.146389. [Epub ahead of print] Review. PMID: 31425679

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. Etchegaray JP, Zhong L, Li C, Henriques T, Ablondi E, Nakadai T, Van Rechem C, Ferrer C, Ross KN, Choi JE, Samarakkody A, Ji F, Chang A, Sadreyev RI, Ramaswamy S, Nechaev S, Whetstine JR, Roeder RG, Adelman K, Goren A, Mostoslavsky R. Mol Cell. 2019 Aug 22;75(4):683-699.e7. doi: 10.1016/j.molcel.2019.06.034. Epub 2019 Aug 6. PMID: 31399344

Tbx5 inhibits hedgehog signaling in determination of digit identity. Xu H, Xiang M, Qin Y, Cheng H, Chen D, Fu Q, Zhang KK, Xie L. Hum Mol Genet. 2019 Aug 2. pii: ddz185. doi: 10.1093/hmg/ddz185. [Epub ahead of print]
PMID: 31373354

Genome-wide DNA methylation profiling of human diabetic peripheral neuropathy in subjects with type 2 diabetes mellitus. Guo K, Elzinga S, Eid S, Figueroa-Romero C, Hinder LM, Pacut C, Feldman EL, Hur J. Epigenetics. 2019 Aug;14(8):766-779. doi: 10.1080/15592294.2019.1615352. Epub 2019 May 28. PMID: 31132961

Degradable antimicrobial polycarbonates with unexpected activity and selectivity for treating multidrug-resistant Klebsiella pneumoniae lung infection in mice. Yang C, Lou W, Zhong G, Lee A, Leong J, Chin W, Ding B, Bao C, Tan JPK, Pu Q, Gao S, Xu L, Hsu LY, Wu M, Hedrick JL, Fan W, Yang YY. Acta Biomater. 2019 Aug;94:268-280. doi: 10.1016/j.actbio.2019.05.057. Epub 2019 May 24. PMID: 31129359

Methamphetamine exacerbates neuroinflammatory response to lipopolysaccharide by activating dopamine D1-like receptors. Wang B, Chen T, Xue L, Wang J, Jia Y, Li G, Ren H, Wu F, Wu M, Chen Y. Int Immunopharmacol. 2019 Aug;73:1-9. doi: 10.1016/j.intimp.2019.04.053. Epub 2019 May 9. PMID: 31078920

Tamoxifen restores extracellular trap formation in neutrophils from patients with chronic granulomatous disease in a reactive oxygen species-independent manner. Sharma A, McCann K, Tripathi JK, Chauhan P, Zerbe C, Mishra BB, Holland SM, Sharma J. J Allergy Clin Immunol. 2019 Aug;144(2):597-600.e3. doi: 10.1016/j.jaci.2019.04.014. Epub 2019 Apr 27. PMID: 31039377

Pseudomonas aeruginosa Regulatory Protein AnvM Controls Pathogenicity in Anaerobic Environments and Impacts Host Defense. Zhang Y, Zhou CM, Pu Q, Wu Q, Tan S, Shao X, Zhang W, Xie Y, Li R, Yu XJ, Wang R, Zhang L, Wu M, Deng X. MBio. 2019 Jul 23;10(4). pii: e01362-19. doi: 10.1128/mBio.01362-19. PMID: 31337721

Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons. Nash B, Tarn K, Irollo E, Luchetta J, Festa L, Halcrow P, Datta G, Geiger JD, Meucci O. eNeuro. 2019 Jul 31;6(4). pii: ENEURO.0237-19.2019. doi: 10.1523/ENEURO.0237-19.2019. Print 2019 Jul/Aug. PMID: 31300544

Schlafen 3 knockout mice display gender-specific differences in weight gain, food efficiency, and expression of markers of intestinal epithelial differentiation, metabolism, and immune cell function. Vomhof-DeKrey EE, Lee J, Lansing J, Brown C, Darland D, Basson MD. PLoS One. 2019 Jul 1;14(7):e0219267. doi: 10.1371/journal.pone.0219267. eCollection 2019. PMID: 31260507

Double-Edged Role of Interleukin 17A in Streptococcus pneumoniae Pathogenesis During Influenza Virus Coinfection. Ambigapathy G, Schmit T, Mathur RK, Nookala S, Bahri S, Pirofski LA, Khan MN. J Infect Dis. 2019 Jul 31;220(5):902-912. doi: 10.1093/infdis/jiz193. PMID: 31185076

Ca2+ entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex. Schaar A, Sun Y, Sukumaran P, Rosenberger TA, Krout D, Roemmich JN, Brinbaumer L, Claycombe-Larson K, Singh BB. J Cell Sci. 2019 Jul 1;132(13). pii: jcs231878. doi: 10.1242/jcs.231878. PMID: 31182642

Overexpression of GATA2 Enhances Development and Maintenance of Human Embryonic Stem Cell-Derived Hematopoietic Stem Cell-like Progenitors. Zhou Y, Zhang Y, Chen B, Dong Y, Zhang Y, Mao B, Pan X, Lai M, Chen Y, Bian G, Zhou Q, Nakahata T, Zhou J, Wu M, Ma F. Stem Cell Reports. 2019 Jul 9;13(1):31-47. doi: 10.1016/j.stemcr.2019.05.007. Epub 2019 Jun 6. PMID: 31178416

Methamphetamine exacerbates neuroinflammatory response to lipopolysaccharide by activating dopamine D1-like receptors. Wang B, Chen T, Xue L, Wang J, Jia Y, Li G, Ren H, Wu F, Wu M, Chen Y. Int Immunopharmacol. 2019 Aug;73:1-9. doi: 10.1016/j.intimp.2019.04.053. Epub 2019 May 9. PMID: 31078920

Schlafen 12 mediates the effects of butyrate and repetitive mechanical deformation on intestinal epithelial differentiation in human Caco-2 intestinal epithelial cells. Chaturvedi LS, Wang Q, More SK, Vomhof-DeKrey EE, Basson MD. Hum Cell. 2019 Jul;32(3):240-250. doi: 10.1007/s13577-019-00247-3. Epub 2019 Mar 14. PMID: 30875077

Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences. Quinlan MA, Krout D, Katamish RM, Robson MJ, Nettesheim C, Gresch PJ, Mash DC, Henry LK, Blakely RD. ACS Chem Neurosci. 2019 Jul 17;10(7):3249-3260. doi: 10.1021/acschemneuro.8b00689. Epub 2019 Feb 5. PMID: 30668912

Palmitate-Induced SREBP1 Expression and Activation Underlies the Increased BACE 1 Activity and Amyloid Beta Genesis. Marwarha G, Claycombe-Larson K, Lund J, Ghribi O. Mol Neurobiol. 2019 Jul;56(7):5256-5269. doi: 10.1007/s12035-018-1451-8. Epub 2018 Dec 19. PMID: 30569418

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression. Wang Z, Pu Q, Lin P, Li C, Jiang J, Wu M. J Vis Exp. 2019 Jun 15;(148). doi: 10.3791/59386. PMID: 31259890

Genome-wide RNA pol II initiation and pausing in neural progenitors of the rat. Scheidegger A, Dunn CJ, Samarakkody A, Koney NK, Perley D, Saha RN, Nechaev S. BMC Genomics. 2019 Jun 11;20(1):477. doi: 10.1186/s12864-019-5829-4.
PMID: 31185909

Ca2+ entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex. Schaar A, Sun Y, Sukumaran P, Rosenberger TA, Krout D, Roemmich JN, Brinbaumer L, Claycombe-Larson K, Singh BB. J Cell Sci. 2019 Jun 10. pii: jcs.231878. doi: 10.1242/jcs.231878. [Epub ahead of print]
PMID: 31182642

Trace minerals in tilapia fillets: Status in the United States marketplace and selenium supplementation strategy for improving consumer's health. Farzad R, Kuhn DD, Smith SA, O'Keefe SF, Ralston NVC, Neilson AP, Gatlin DM.
PLoS One. 2019 Jun 6;14(6):e0217043. doi: 10.1371/journal.pone.0217043. eCollection 2019. PMID: 31170189

Roles of K+ and cation channels in ORL-1 receptor-mediated depression of neuronal excitability and epileptic activities in the medial entorhinal cortex. Li H, Hu B, Zhang HP, Boyle CA, Lei S.
Neuropharmacology. 2019 Jun;151:144-158. doi: 10.1016/j.neuropharm.2019.04.017. Epub 2019 Apr 15. PMID: 30998945

Palmitoylation by Multiple DHHC Enzymes Enhances Dopamine Transporter Function and Stability. Bolland DE, Moritz AE, Stanislowski DJ, Vaughan RA, Foster JD.
ACS Chem Neurosci. 2019 Jun 19;10(6):2707-2717. doi: 10.1021/acschemneuro.8b00558. Epub 2019 Apr 19. PMID: 30965003

Inflammatory mechanisms in neurodegeneration. Nichols MR, St-Pierre MK, Wendeln AC, Makoni NJ, Gouwens LK, Garrad EC, Sohrabi M, Neher JJ, Tremblay ME, Combs CK.
J Neurochem. 2019 Jun;149(5):562-581. doi: 10.1111/jnc.14674. Epub 2019 Mar 27. Review. PMID: 30702751

Toll-like receptors and inflammation in metabolic neuropathy; a role in early versus late disease? Elzinga S, Murdock BJ, Guo K, Hayes JM, Tabbey MA, Hur J, Feldman EL. Exp Neurol. 2019 May 27:112967. doi: 10.1016/j.expneurol.2019.112967. [Epub ahead of print] PMID:31145897

Genome-wide DNA methylation profiling of human diabetic peripheral neuropathy in subjects with type 2 diabetes mellitus. Guo K, Elzinga S, Eid S, Figueroa-Romero C, Hinder LM, Pacut C, Feldman EL, Hur J. Epigenetics. 2019 May 28:1-14. doi: 10.1080/15592294.2019.1615352. [Epub ahead of print] PMID: 31132961

Degradable antimicrobial polycarbonates with unexpected activity and selectivity for treating multidrug-resistant Klebsiella pneumoniae lung infection in mice. Yang C, Lou W, Zhong G, Lee A, Leong J, Chin W, Ding B, Bao C, Tan JPK, Pu Q, Gao S, Xu L, Yang Hsu L, Wu M, Hedrick JL, Fan W, Yan Yang Y. Acta Biomater. 2019 May 23. pii: S1742-7061(19)30384-8. doi: 10.1016/j.actbio.2019.05.057. [Epub ahead of print] PMID: 31129359

Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development. Liu J, Cheng H, Xiang M, Zhou L, Wu B, Moskowitz IP, Zhang K, Xie L. PLoS Genet. 2019 May 23;15(5):e1007711. doi: 10.1371/journal.pgen.1007711. [Epub ahead of print] PMID:31120883

Methamphetamine exacerbates neuroinflammatory response to lipopolysaccharide by activating dopamine D1-like receptors. Wang B, Chen T, Xue L, Wang J, Jia Y, Li G, Ren H, Wu F, Wu M, Chen Y. Int Immunopharmacol. 2019 May 9;73:1-9. doi: 10.1016/j.intimp.2019.04.053. [Epub ahead of print] PMID:31078920

Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes. Thomas C, Ji Y, Wu C, Datz H, Boyle C, MacLeod B, Patel S, Ampofo M, Currie M, Harbin J, Pechenkina K, Lodhi N, Johnson SJ, Tulin AV. Proc Natl Acad Sci U S A. 2019 May 14;116(20):9941-9946. doi: 10.1073/pnas.1901183116. Epub 2019 Apr 26. PMID:31028139

TICK TOCK-Time Is Running Out, as the United States Is Being Invaded by the Longhorned Tick! Brissette CA. Vector Borne Zoonotic Dis. 2019 May;19(5):307-308. doi: 10.1089/vbz.2019.2473. Epub 2019 Apr 9. No abstract available. PMID:30964394

Tamoxifen restores extracellular trap formation in neutrophils from patients of chronic granulomatous disease, in ROS-independent manner. Sharma A, McCann K, Tripathi JK, Chauhan P, Zerbe C, Mishra BB, Holland SM, Sharma J. J Allergy Clin Immunol. 2019 Apr 27. pii: S0091-6749(19)30547-0. doi: 10.1016/j.jaci.2019.04.014. [Epub ahead of print] PMID: 31039377

Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes. Thomas C, Ji Y, Wu C, Datz H, Boyle C, MacLeod B, Patel S, Ampofo M, Currie M, Harbin J, Pechenkina K, Lodhi N, Johnson SJ, Tulin AV. Proc Natl Acad Sci U S A. 2019 Apr 26. pii: 201901183. doi: 10.1073/pnas.1901183116. [Epub ahead of print] PMID: 31028139

Roles of K+ and cation channels in ORL-1 receptor-mediated depression of neuronal excitability and epileptic activities in the medial entorhinal cortex. Li H, Hu B, Zhang HP, Boyle CA, Lei S. Neuropharmacology. 2019 Apr 15;151:144-158. doi: 10.1016/j.neuropharm.2019.04.017. [Epub ahead of print] PMID: 30998945

TICK TOCK-Time Is Running Out, as the United States Is Being Invaded by the Longhorned Tick! Brissette CA. Vector Borne Zoonotic Dis. 2019 Apr 9. doi: 10.1089/vbz.2019.2473. [Epub ahead of print] No abstract available.
PMID: 30964394

A Network Pharmacology Approach for the Identification of Common Mechanisms of Drug-Induced Peripheral Neuropathy. de Anda-Jáuregui G, McGregor BA, Guo K, Hur J. CPT Pharmacometrics Syst Pharmacol. 2019 Apr;8(4):211-219. doi: 10.1002/psp4.12383. Epub 2019 Feb 20. PMID: 30762308

Effects of silica nanoparticles on endolysosome function in primary cultured neurons 1. Ye Y, Hui L, Lakpa KL, Xing Y, Wollenzien H, Chen X, Zhao JX, Geiger JD. Can J Physiol Pharmacol. 2019 Apr;97(4):297-305. doi: 10.1139/cjpp-2018-0401. Epub 2018 Oct 12. PMID: 30312546

Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia. Nieborowska-Skorska M, Maifrede S, Ye M, Toma M, Hewlett E, Gordon J, Le BV, Sliwinski T, Zhao H, Piwocka K, Valent P, Tulin AV, Childers W, Skorski T. Leuk Lymphoma. 2019 Apr;60(4):1098-1101. doi: 10.1080/10428194.2018.1520988. Epub 2018 Oct 2. No abstract available. PMID: 30277116

Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa. Hoggarth A, Weaver A, Pu Q, Huang T, Schettler J, Chen F, Yuan X, Wu M. Drug Des Devel Ther. 2019 Mar 20;13:909-924. doi: 10.2147/DDDT.S189847. eCollection 2019. Review. PMID:30936684

11Zika Virus-Specific IgY Results Are Therapeutic Following a Lethal Zika Virus Challenge without Inducing Antibody-Dependent Enhancement. O'Donnell KL, Meberg B, Schiltz J, Nilles ML, Bradley DS. Viruses. 2019 Mar 26;11(3). pii: E301. doi: 10.3390/v030301. PMID:30917523

Microenvironment-sensing, nanocarrier-mediated delivery of combination chemotherapy for pancreatic cancer. Ray P, Nair G, Ghosh A, Banerjee S, Golovko MY, Banerjee SK, Reindl KM, Mallik S, Quadir M. J Cell Commun Signal. 2019 Mar 26. doi: 10.1007/s12079-019-00514-w. [Epub ahead of print] PMID:30915617

Schlafen 12 mediates the effects of butyrate and repetitive mechanical deformation on intestinal epithelial differentiation in human Caco-2 intestinal epithelial cells. Chaturvedi LS, Wang Q, More SK, Vomhof-DeKrey EE, Basson MD. Hum Cell. 2019 Mar 14. doi: 10.1007/s13577-019-00247-3. [Epub ahead of print] PMID: 30875077

Correction to: Pathway crosstalk perturbation network modeling for identification of connectivity changes induced by diabetic neuropathy and pioglitazone. de Anda-Jáuregui G, Guo K, McGregor BA, Feldman EL, Hur J. BMC Syst Biol. 2019 Mar 13;13(1):31. doi: 10.1186/s12918-019-0707-x. PMID:30866938

Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha. Askvig JM, Watt JA. J Comp Neurol. 2019 Mar 12. doi: 10.1002/cne.24675. [Epub ahead of print] PMID:30861131

CdpR Inhibits CRISPR-Cas Adaptive Immunity to Lower Anti-viral Defense while Avoiding Self-Reactivity. Lin P, Pu Q, Shen G, Li R, Guo K, Zhou C, Liang H, Jiang J, Wu M. iScience. 2019 Mar 29;13:55-68. doi: 10.1016/j.isci.2019.02.005. Epub 2019 Feb 15. PMID:30822746

A Computational Platform and Guide for Acceleration of Novel Medicines and Personalized Medicine. Melas IN, Sakellaropoulos T, Hur J, Messinis D, Guo EY, Alexopoulos LG, Bai JPF Methods Mol Biol. 2019;1939:181-198. doi: 10.1007/978-1-4939-9089-4_10. Methods Mol Biol.  2019. PMID:30848462

Dephosphorylation of human dopamine transporter at threonine 48 by protein phosphatase PP1/2A up-regulates transport velocity. Yang JW, Larson G, Konrad L, Shetty M, Holy M, Jäntsch K, Kastein M, Heo S, Erdem FA, Lubec G, Vaughan RA, Sitte HH, Foster JD. J Biol Chem. 2019 Mar 8;294(10):3419-3431. doi: 10.1074/jbc.RA118.005251. Epub 2018 Dec 26. PMID:30587577

A Network Pharmacology Approach for the Identification of Common Mechanisms of Drug-Induced Peripheral Neuropathy. de Anda-Jáuregui G, McGregor BA, Guo K, Hur J. CPT Pharmacometrics Syst Pharmacol. 2019 Feb 14. doi: 10.1002/psp4.12383. [Epub ahead of print] PMID:30762308

Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases. Wang K, Chen Y, Zhang P, Lin P, Xie N, Wu M. Cells. 2019 Feb 3;8(2). pii: E123. doi: 10.3390/cells8020123. Review. PMID:30717487

Nucleolin Is a Functional Binding Protein for Salinomycin in Neuroblastoma Stem Cells. Wang F, Zhou S, Qi D, Xiang SH, Wong ET, Wang X, Fonkem E, Hsieh TC, Yang J, Kirmani B, Shabb JB, Wu JM, Wu M, Huang JH, Yu WH, Wu E. J Am Chem Soc. 2019 Feb 27;141(8):3613-3622. doi: 10.1021/jacs.8b12872. Epub 2019 Feb 13. PMID: 30689374

Directed Nucleosome Sliding during the Formation of the Simian Virus 40 Particle Exposes DNA Sequences Required for Early Transcription. Kumar MA, Kasti K, Balakrishnan L, Milavetz B. J Virol. 2019 Feb 5;93(4). pii: e01678-18. doi: 10.1128/JVI.01678-18. Print 2019 Feb 15. PMID: 30518654

Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach. de Anda-Jáuregui G, Espinal-Enríquez J, Hur J, Alcalá-Corona SA, Ruiz-Azuara L, Hernández-Lemus E. Comput Biol Chem. 2019 Feb;78:127-132. doi: 10.1016/j.compbiolchem.2018.11.021. Epub 2018 Nov 23. PMID: 30504090

Model systems for analysis of dopamine transporter function and regulation. Hovde MJ, Larson GH, Vaughan RA, Foster JD. Neurochem Int. 2019 Feb;123:13-21. doi: 10.1016/j.neuint.2018.08.015. Epub 2018 Sep 1. PMID: 30179648

Identification of the benztropine analog [125I]GA II 34 binding site on the human dopamine transporter. Tomlinson MJ, Krout D, Pramod AB, Lever JR, Newman AH, Henry LK, Vaughan RA. Neurochem Int. 2019 Feb;123:34-45. doi: 10.1016/j.neuint.2018.08.008. Epub 2018 Aug 17. PMID: 30125594

A Diet Enriched in Palmitate and Deficient in Linoleate Exacerbates Oxidative Stress and Amyloid-β Burden in the Hippocampus of 3xTg-AD Mouse Model of Alzheimer's Disease. Marwarha G, Claycombe-Larson K, Lund J, Schommer J, Ghribi O. J Alzheimers Dis. 2019 Jan 28. doi: 10.3233/JAD-180835. [Epub ahead of print]
PMID: 30714957

 The Importance of Ethics in Scientific Research. Lawrence R. Lipids. 2019 Jan 29. doi: 10.1002/lipd.12118. [Epub ahead of print] No abstract available. PMID: 30693960

 PARP-1/2 Inhibitor Olaparib Prevents or Partially Reverts EMT Induced by TGF-β in NMuMG Cells. Schacke M, Kumar J, Colwell N, Hermanson K, Folle GA, Nechaev S, Dhasarathy A, Lafon-Hughes L. Int J Mol Sci. 2019 Jan 26;20(3). pii: E518. doi: 10.3390/ijms20030518. PMID: 30691122

 Network-Based Assessment of Adverse Drug Reaction Risk in Polypharmacy Using High-Throughput Screening Data. de Anda-Jáuregui G, Guo K, Hur J. Int J Mol Sci. 2019 Jan 17;20(2). pii: E386. doi: 10.3390/ijms20020386.
PMID: 30658437

 Pathway crosstalk perturbation network modeling for identification of connectivity changes induced by diabetic neuropathy and pioglitazone. de Anda-Jáuregui G, Guo K, McGregor BA, Feldman EL, Hur J. BMC Syst Biol. 2019 Jan 7;13(1):1. doi: 10.1186/s12918-018-0674-7. PMID: 30616626

 Getting to the Heart of Alzheimer Disease. Tublin JM, Adelstein JM, Del Monte F, Combs CK, Wold LE. Circ Res. 2019 Jan 4;124(1):142-149. doi: 10.1161/CIRCRESAHA.118.313563. PMID: 30605407

 Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis. Hui L, Soliman ML, Geiger NH, Miller NM, Afghah Z, Lakpa KL, Chen X, Geiger JD. J Alzheimers Dis. 2019;67(1):393-410. doi: 10.3233/JAD-180941. PMID: 30594929

 Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues. Kulas JA, Franklin WF, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK. Am J Physiol Endocrinol Metab. 2019 Jan 1;316(1):E106-E120. doi: 10.1152/ajpendo.00279.2018. Epub 2018 Nov 13. Erratum in: Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E345. PMID: 30422705

 TRPC1 intensifies house dust mite-induced airway remodeling by facilitating epithelial-to-mesenchymal transition and STAT3/NF-κB signaling. Pu Q, Zhao Y, Sun Y, Huang T, Lin P, Zhou C, Qin S, Singh BB, Wu M. FASEB J. 2019 Jan;33(1):1074-1085. doi: 10.1096/fj.201801085R. Epub 2018 Aug 1. PMID: 30067380

2018 Publications

Heterogeneity in FoxP3- and GARP/LAP-Expressing T Regulatory Cells in an HLA Class II Transgenic Murine Model of Necrotizing Soft Tissue Infections by Group A Streptococcus. Nookala S, Mukundan S, Fife A, Alagarsamy J, Kotb M. Infect Immun. 2018 Nov 20;86(12). pii: e00432-18. doi: 10.1128/IAI.00432-18. Print 2018 Dec. PMID: 30224551

Trends of self-reported sleep duration in Korean Adults: results from the Korea National Health and Nutrition Examination Survey 2007-2015. Shin D, Hur J, Cho KH, Cho EH. Sleep Med. 2018 Dec;52:103-106. doi: 10.1016/j.sleep.2018.08.008. Epub 2018 Sep 4. PMID: 30308449

A long-term maternal diet intervention is necessary to avoid the obesogenic effect of maternal high-fat diet in the offspring. Xu H, Fu Q, Zhou Y, Xue C, Olson P, Lynch EC, Zhang KK, Wu C, Murano P, Zhang L, Xie L. J Nutr Biochem. 2018 Dec;62:210-220. doi: 10.1016/j.jnutbio.2018.09.008. Epub 2018 Sep 22. PMID: 30316166

Directed Nucleosome Sliding in SV40 Minichromosomes During the Formation of the Virus Particle Exposes DNA Sequences Required for Early Transcription. Kumar MA, Kasti K, Balakrishnan L, Milavetz B. J Virol. 2018 Dec 5. pii: JVI.01678-18. doi: 10.1128/JVI.01678-18. [Epub ahead of print] PMID: 30518654

Conserved Transcriptional Signatures in Human and Murine Diabetic Peripheral Neuropathy. McGregor BA, Eid S, Rumora AE, Murdock B, Guo K, de Anda-Jáuregui G, Porter JE, Feldman EL, Hur J. Sci Rep. 2018 Dec 5;8(1):17678. doi: 10.1038/s41598-018-36098-5. PMID: 30518872

Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis. Hui L, Soliman LM, Geiger HN, Miller MN, Afghah Z, Lakpa LK, Chen X, Geiger DJ. J Alzheimers Dis. 2018 Dec 28. doi: 10.3233/JAD-180941. [Epub ahead of print] PMID: 30594929

Association of Sleep Duration and Obesity According to Gender and Age in Korean Adults: Results from the Korea National Health and Nutrition Examination Survey 2007-2015. Cho KH, Cho EH, Hur J, Shin D. J Korean Med Sci. 2018 Dec 17;33(53):e345. doi: 10.3346/jkms.2018.33.e345. eCollection 2018 Dec 31. PMID: 30595686

Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach. de Anda-Jáuregui G, Espinal-Enríquez J, Hur J, Alcalá-Corona SA, Ruiz-Azuara L, Hernández-Lemus E. Comput Biol Chem. 2018 Nov 23;78:127-132. doi: 10.1016/j.compbiolchem.2018.11.021. [Epub ahead of print] PMID:30504090

Decision Making in Colostomy Closure: Acceptable vs Optimal Safety and Selection vs Bias. Basson MD. JAMA Surg. 2018 Nov 21. doi: 10.1001/jamasurg.2018.4366. [Epub ahead of print] No abstract available. PMID:  30476977

Ablation of Amyloid Precursor Protein Increases Insulin Degrading Enzyme Levels and Activity in Brain and Peripheral Tissues. Kulas JA, Franklin W, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK. Am J Physiol Endocrinol Metab. 2018 Nov 13. doi:  10.1152/ajpendo.00279.2018. [Epub ahead of print] PMID: 30422705

DNA Methylation by Restriction Modification Systems Affects the Global Transcriptome Profile in Borrelia burgdorferi. Casselli T, Tourand Y, Scheidegger A, Arnold WK, Proulx A, Stevenson B, Brissette CA. J Bacteriol. 2018 Nov 26;200(24). pii: e00395-18. doi: 10.1128/JB.00395-18. Print 2018 Dec 15. PMID: 30249703

Dopaminergic neurotoxins induce cell death by attenuating NF-κB-mediated regulation of TRPC1 expression and autophagy. Sukumaran P, Sun Y, Antonson N, Singh BB.FASEB J. 2017 Nov 17. pii: fj.201700662RR. doi: 10.1096/fj.201700662RR. [Epub ahead of print] PMID:29150520

Function of SLAM-Associated Protein (SAP) in Acute Pneumoseptic Bacterial Infection. Tripathi JK, Sharma A, Gupta K, Abdelrahman H, Chauhan P, Mishra BB, Sharma J. J Mol Biol. 2019 Oct 4;431(21):4345-4353. doi: 10.1016/j.jmb.2019.07.002. Epub 2019 Jul 8.

Airway epithelial TSLP production of TLR2 drives type 2 immunity in allergic airway inflammation. Lv J, Yu Q, Lv J, Di C, Lin X, Su W, Wu M, Xia Z. Eur J Immunol. 2018 Nov;48(11):1838-1850. doi: 10.1002/eji.201847663. Epub 2018 Oct 12. PMID: 30184256 

Better Quality Metrics Could Illuminate Quality-Efficiency Tradeoffs in Operating Room Management.
Basson MD. J Invest Surg. 2018 Oct 31:1-2. doi: 10.1080/08941939.2018.1493552. [Epub ahead of print] No abstract available. PMID: 30380345

Role of Inflammatory Risk Factors in the Pathogenesis of Streptococcus pneumoniae. Sohail I, Ghosh S, Mukundan S, Zelewski S, Khan MN. Front Immunol. 2018 Oct 2;9:2275. doi: 10.3389/fimmu.2018.02275. eCollection 2018. Review. PMID:30333833

Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma. Lv J, Su W, Yu Q, Zhang M, Di C, Lin X, Wu M, Xia Z. J Biol Chem. 2018 Oct 17. pii:jbc.RA118.004950. doi: 10.1074/jbc.RA118.004950. [Epub ahead of print] PMID: 30333233

Effects of silica nanoparticles on endolysosome function in primary cultured neurons. Ye Y, Hui L, Lakpa KL, Xing Y, Wollenzien H, Chen X, Zhao J, Geiger JD. Can J Physiol Pharmacol. 2018 Oct 12. doi: 10.1139/cjpp-2018-0401. [Epub ahead of print] PMID:30312546

M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry. Chauhan A, Sun Y, Sukumaran P, Quenum Zangbede FO, Jondle CN, Sharma A, Evans DL, Chauhan P, Szlabick RE, Aaland MO, Birnbaumer L, Sharma J, Singh BB, Mishra BB. iScience. 2018 Oct 26;8:85-102. doi: 10.1016/j.isci.2018.09.014. Epub 2018 Sep 20. PMID: 30293012

Systolic and Diastolic Blood Pressure Variability as Risk Factors for Adverse Events After Coronary Artery Bypass Grafting. Dyke CM, Benz CL, Taggart CM, Klug MG, Basson MD. JAMA Surg. 2018 Oct 3. doi: 10.1001/jamasurg.2018.3233. [Epub ahead of print] No abstract available. PMID: 30285062

Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia. Nieborowska-Skorska M, Maifrede S, Ye M, Toma M, Hewlett E, Gordon J, Le BV, Sliwinski T, Zhao H, Piwocka K, Valent P, Tulin AV, Childers W, Skorski T. Leuk Lymphoma. 2018 Oct 2:1-4. doi: 10.1080/10428194.2018.1520988. [Epub ahead of print] No abstract available. PMID: 30277116

Klebsiella pneumoniae infection of murine neutrophils impairs their efferocytic clearance by modulating cell death machinery. Jondle CN, Gupta K, Mishra BB, Sharma J. PLoS Pathog. 2018 Oct 1;14(10):e1007338. doi: 10.1371/journal.ppat.1007338. eCollection 2018 Oct. PMID:30273394

27-hydroxycholesterol decreases cell proliferation in colon cancer cell lines. Warns J, Marwarha G, Freking N, Ghribi O. Biochimie. 2018 Oct;153:171-180. doi: 10.1016/j.biochi.2018.07.006. Epub 2018 Jul 24. PMID: 30009860

Transcriptional networks of progressive diabetic peripheral neuropathy in the db/db mouse model of type 2 diabetes: An inflammatory story. Hinder LM, Murdock BJ, Park M, Bender DE, O'Brien PD, Rumora AE, Hur J, Feldman EL. Exp Neurol. 2018 Jul;305:33-43. doi: 10.1016/j.expneurol.2018.03.011. Epub 2018 Mar 14. PMID:29550371 

Questionable Assumptions Provided in Nonoperative Treatment of Appendicitis Survey-Reply. Basson MD, Hanson AL, Crosby RD. JAMA Surg. 2018 Oct 1;153(10):970. doi: 10.1001/jamasurg.2018.2063. No abstract available. PMID: 29971345

TRPC1 expression and function inhibit ER stress and cell death in salivary gland cells. Sukumaran P, Sun Y, Zangbede FQ, da Conceicao VN, Mishra B, Singh BB. FASEB Bioadv. 2019 Jan;1(1):40-50. doi: 10.1096/fba.1021. Epub 2018 Oct 8.

Heterogeneity in FoxP3- and GARP/LAP-expressing Tregs in an HLA-II transgenic murine model of Necrotizing Soft Tissue Infections by Group A Streptococcus. Nookala S, Mukundan S, Fife A, Alagarsamy J, Kotb M. Infect Immun. 2018 Sep 17. pii: IAI.00432-18. doi: 10.1128/IAI.00432-18. [Epub ahead of print] PMID: 30224551

Plasma Unesterified Fatty-Acid Profile Is Dramatically and Acutely Changed under Ischemic Stroke in the Mouse Model. Golovko SA, Golovko MY. Lipids. 2018 Jun;53(6):641-645. doi: 10.1002/lipd.12073. Epub 2018 Sep 12. PMID: 30206953

Withaferin A Suppresses Beta Amyloid in APP Expressing Cells: Studies for Tat and Cocaine Associated Neurological Dysfunctions. Tiwari S, Atluri VSR, Yndart Arias A, Jayant RD, Kaushik A, Geiger J, Nair MN. Front Aging Neurosci. 2018 Sep 27;10:291. doi: 10.3389/fnagi.2018.00291. eCollection 2018. PMID:30356847

Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes. Arifuzzaman M, Ang WXG, Choi HW, Nilles ML, St John AL, Abraham SN. JCI Insight. 2018 Sep 20;3(18). pii: 122188. doi: 10.1172/jci.insight.122188. PMID:30232285

Model systems for analysis of dopamine transporter function and regulation. Hovde MJ, Larson GH, Vaughan RA, Foster JD. Neurochem Int. 2018 Sep 1. pii: S0197-0186(18)30293-6. doi: 10.1016/j.neuint.2018.08.015. [Epub ahead of print] PMID:30179648

Visit-to-Visit Variability of Blood Pressure Is Associated With Hospitalization and Mortality in an Unselected Adult Population. Basson MD, Klug MG, Hostetter JE, Wynne J. Am J Hypertens. 2018 Sep 11;31(10):1113-1119. doi: 10.1093/ajh/hpy088. PMID:29860426

Transcriptomic insights on the virulence-controlling CsrA, BadR, RpoN, and RpoS regulatory networks in the Lyme disease spirochete. Arnold WK, Savage CR, Lethbridge KG, Smith TC 2nd, Brissette CA, Seshu J, Stevenson B. PLoS One. 2018 Aug 30;13(8):e0203286. doi: 10.1371/journal.pone.0203286. eCollection 2018. PMID: 30161198

Rho-kinase inhibitor fasudil reduces allergic airway inflammation and mucus hypersecretion by regulating STAT6 and NFκB. Xie T, Luo G, Zhang Y, Wang X, Wang X, Wu M, Li G. Clin Exp Allergy. 2015 Dec;45(12):1812-22. doi: 10.1111/cea.12606. PMID:26245530

Intranasal coinfection model allows for assessment of protein vaccines against nontypeable Haemophilus influenzae in mice. Michel LV, Kaur R, Zavorin M, Pryharski K, Khan MN, LaClair C, O'Neil M, Xu Q, Pichichero ME. J Med Microbiol. 2018 Aug 23. doi: 10.1099/jmm.0.000827. [Epub ahead of print] PMID: 30136923

Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model. Vacano GN, Gibson DS, Turjoman AA, Gawryluk JW, Geiger JD, Duncan M, Patterson D. Neurobiol Aging. 2018 Mar;63:96-109. doi: 10.1016/j.neurobiolaging.2017.11.010. Epub 2017 Nov 26. PMID:29245059

Palmitic Acid-Enriched Diet Increases α-Synuclein and Tyrosine Hydroxylase Expression Levels in the Mouse Brain. Schommer J, Marwarha G, Nagamoto-Combs K, Ghribi O. Front Neurosci. 2018 Aug 6;12:552. doi: 10.3389/fnins.2018.00552. eCollection 2018. PMID: 30127714

Identification of the benztropine analog [125I]GA II 34 binding site on the human dopamine transporter. Tomlinson MJ, Krout D, Pramod AB, Lever JR, Newman AH, Henry LK, Vaughan RA. Neurochem Int. 2018 Aug 17. pii: S0197-0186(18)30241-9. doi: 10.1016/j.neuint.2018.08.008. [Epub ahead of print] PMID: 30125594

MPP+ decreases store-operated calcium entry and TRPC1 expression in Mesenchymal Stem Cell derived dopaminergic neurons. Sun Y, Selvaraj S, Pandey S, Humphrey KM, Foster JD, Wu M, Watt JA, Singh BB, Ohm JE. Sci Rep. 2018 Aug 6;8(1):11715. doi: 10.1038/s41598-018-29528-x. PMID: 30082759

TRPC1 intensifies house dust mite-induced airway remodeling by facilitating epithelial-to-mesenchymal transition and STAT3/NF-κB signaling. Pu Q, Zhao Y, Sun Y, Huang T, Lin P, Zhou C, Qin S, Singh BB, Wu M. FASEB J. 2018 Aug 1:fj201801085R. doi: 10.1096/fj.201801085R. [Epub ahead of print] PMID: 30067380

Identification of potential small-molecule protein-protein inhibitors of cancer metastasis by 3D epitope-based computational screening. Raschka S, More SK, Devadoss D, Zeng B, Kuhn LA, Basson MD. J Physiol Pharmacol. 2018 Apr;69(2). doi: 10.26402/jpp.2018.2.11. Epub 2018 Jul 4. PMID:29980145

Cancer Metastasis to the Peritoneum: Bad Luck or Dysregulated Biology? Basson MD. J Invest Surg. 2018 Aug;31(4):357-358. doi: 10.1080/08941939.2017.1331281. Epub 2017 Jun 9. No abstract available. PMID: 28598704

Anti-a4ß1 integrin antibodies attenuated brain inflammatory changes in a mouse model of Alzheimer's disease. Combs C, Manocha G, Ghatak A, Puig K. Curr Alzheimer Res. 2018 Jul 31. doi: 10.2174/1567205015666180801111033. [Epub ahead of print] PMID: 30068274

Abnormal RNA stability in amyotrophic lateral sclerosis. Tank EM, Figueroa-Romero C, Hinder LM, Bedi K, Archbold HC, Li X, Weskamp K, Safren N, Paez-Colasante X, Pacut C, Thumma S, Paulsen MT, Guo K, Hur J, Ljungman M, Feldman EL, Barmada SJ. Nat Commun. 2018 Jul 20;9(1):2845. doi: 10.1038/s41467-018-05049-z. PMID:30030424

Novel management strategies for medically-refractory vasospasm following aneurysmal subarachnoid hemorrhage. Al-Mufti F, Amuluru K, Damodara N, El-Ghanem M, Nuoman R, Kamal N, Al-Marsoummi S, Morris NA, Dangayach NS, Mayer SA. J Neurol Sci. 2018 Jul 15;390:44-51. doi: 10.1016/j.jns.2018.02.039. Epub 2018 Feb 23. Review. PMID:29801906

Novel minimally invasive multi-modality monitoring modalities in neurocritical care. Al-Mufti F, Smith B, Lander M, Damodara N, Nuoman R, El-Ghanem M, Kamal N, Al-Marsoummi S, Alzubaidi B, Nuoaman H, Foreman B, Amuluru K, Gandhi CD. J Neurol Sci. 2018 Jul 15;390:184-192. doi: 10.1016/j.jns.2018.03.032. Epub 2018 Mar 28. Review. PMID:29801883

Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation. Brown-Borg HM, Rakoczy S, Wonderlich JA, Borg KE, Rojanathammanee L. Ann N Y Acad Sci. 2018 Apr;1418(1):118-136. doi: 10.1111/nyas.13687. PMID:29722030

A novel role for the macrophage galactose-type lectin (MGL) receptor in mediating von Willebrand factor clearance. Ward SE, O'Sullivan JM, Drakeford C, Aguila S, Jondle CN, Sharma J, Fallon PG, Brophy TM, Preston RJS, Smyth P, Sheils O, Chion A, O'Donnell JS. Blood. 2017 Dec 27. pii: blood-2017-06-787853. doi: 10.1182/blood-2017-06-787853. [Epub ahead of print] PMID:29282218

Laboratory Cultivation and Maintenance of Borrelia miyamotoi. Stone BL, Brissette CA. Curr Protoc Microbiol. 2016 Aug 12;42:12F.1.1-6. doi: 10.1002/cpmc.12. PMID:27517334

Oral Antibiotics for Colon Surgery: The Questions Remain the Same, as Do the Answers. Basson MD. JAMA Surg. 2017 Oct 18. doi: 10.1001/jamasurg.2017.3843. [Epub ahead of print] No abstract available.  PMID:29049520

Lipids: 50th anniversary celebration and the future. Murphy EJ. Lipids. 2015 Jan;50(1):1-2. doi: 10.1007/s11745-014-3986-4. No abstract available.  PMID:25547429

Association of Colonoscopy With Risk of Appendicitis. Basson MD, Persinger D, Newman WP. JAMA Surg. 2017 Oct 4. doi: 10.1001/jamasurg.2017.3790. [Epub ahead of print] No abstract available. PMID:28979984

Advances in omics for informed pharmaceutical research and development in the era of systems medicine. Bai JPF, Melas IN, Hur J, Guo E. Expert Opin Drug Discov. 2017 Oct 27:1-4. doi: 10.1080/17460441.2018.1394839. [Epub ahead of print] No abstract available. PMID:29073782

Corrigendum to "The external gate of the human and Drosophila serotonin transporters requires a basic/acidic amino acid pair for 3,4-methylenedioxymethamphetamine (MDMA) translocation and the induction of substrate efflux" [Biochem. Pharmacol. 120 (2016) 46-55]. Sealover NR, Felts B, Kuntz CP, Jarrard RE, Hockerman GH, Lamb PW, Barker EL, Henry LK. Biochem Pharmacol. 2017 Nov 28;147:9. doi: 10.1016/j.bcp.2017.11.001. [Epub ahead of print] No abstract available. PMID:29195124

Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux. Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Peng Y, Nice EC, Wu M, Huang C, Wei Y. Autophagy. 2017 Nov 26:1-56. doi: 10.1080/15548627.2017.1409405. [Epub ahead of print] PMID:29172997

Schlafen 12 Interaction with SerpinB12 and Deubiquitylases Drives Human Enterocyte Differentiation. Basson MD, Wang Q, Chaturvedi LS, More S, Vomhof-DeKrey EE, Al-Marsoummi S, Sun K, Kuhn LA, Kovalenko P, Kiupel M. Cell Physiol Biochem. 2018 Jul 25;48(3):1274-1290. doi: 10.1159/000492019. [Epub ahead of print] PMID: 30045019

The calcium channel proteins ORAI3 and STIM1 mediate TGF-ß induced Snai1 expression. Bhattacharya A, Kumar J, Hermanson K, Sun Y, Qureshi H, Perley D, Scheidegger A, Singh BB, Dhasarathy A. Oncotarget. 2018 Jun 29;9(50):29468-29483. doi: 10.18632/oncotarget.25672. eCollection 2018 Jun 29. PMID: 30034631

Galectin-3 in M2 Macrophages Plays a Protective Role in Resolution of Neuropathology in Brain Parasitic Infection by Regulating Neutrophil Turnover. Quenum Zangbede FO, Chauhan A, Sharma J, Mishra BB. J Neurosci. 2018 Jul 25;38(30):6737-6750. doi: 10.1523/JNEUROSCI.3575-17.2018. Epub 2018 Jun 26. PMID: 29946038

MEG3-4 is a miRNA decoy that regulates IL-1ß abundance to initiate and then limit inflammation to prevent sepsis during lung infection. Li R, Fang L, Pu Q, Bu H, Zhu P, Chen Z, Yu M, Li X, Weiland T, Bansal A, Ye SQ, Wei Y, Jiang J, Wu M. Sci Signal. 2018 Jun 26;11(536). pii: eaao2387. doi: 10.1126/scisignal.aao2387. PMID: 29945883

Oxidant sensor cation channel TRPM2 regulates neutrophil extracellular trap formation and protects against pneumoseptic bacterial infection. Tripathi JK, Sharma A, Sukumaran P, Sun Y, Mishra BB, Singh BB, Sharma J. FASEB J. 2018 Jun 15:fj201800605. doi: 10.1096/fj.201800605. [Epub ahead of print] PMID: 29906250

Ontology-based literature mining and class effect analysis of adverse drug reactions associated with neuropathy-inducing drugs. Hur J, Özgür A, He Y. J Biomed Semantics. 2018 Jun 7;9(1):17. doi: 10.1186/s13326-018-0185-x. PMID: 29880031

Scp-2/Scp-x ablation in Fabp1 null mice differentially impacts hepatic endocannabinoid level depending on dietary fat. Martin GG, Seeger DR, McIntosh AL, Chung S, Milligan S, Landrock D, Dangott LJ, Golovko MY, Murphy EJ, Kier AB, Schroeder F. Arch Biochem Biophys. 2018 Jul 15;650:93-102. doi: 10.1016/j.abb.2018.05.013. Epub 2018 May 12. PMID: 29763591

Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D2 Autoreceptors Shapes the In Vivo Impact of the Neuropsychiatric Disease-Associated DAT Variant Val559. Gowrishankar R, Gresch PJ, Davis GL, Katamish RM, Riele JR, Stewart AM, Vaughan RA, Hahn MK, Blakely RD. J Neurosci. 2018 Jun 6;38(23):5302-5312. doi: 10.1523/JNEUROSCI.0055-18.2018. Epub 2018 May 8. PMID: 29739866

Borrelia burgdorferi SpoVG DNA- and RNA-Binding Protein Modulates the Physiology of the Lyme Disease Spirochete. Savage CR, Jutras BL, Bestor A, Tilly K, Rosa PA, Tourand Y, Stewart PE, Brissette CA, Stevenson B. J Bacteriol. 2018 May 24;200(12). pii: e00033-18. doi: 10.1128/JB.00033-18. Print 2018 Jun 15. PMID: 29632088

 TGFß-induced epithelial-to-mesenchymal transition in prostate cancer cells is mediated via TRPM7 expression. Sun Y, Schaar A, Sukumaran P, Dhasarathy A, Singh BB. Mol Carcinog. 2018 Jun;57(6):752-761. doi: 10.1002/mc.22797. Epub 2018 Mar 15. PMID: 29500887

miRNAs reshape immunity and inflammatory responses in bacterial infection. Zhou X, Li X, Wu M. Signal Transduct Target Ther. 2018 May 25;3:14. doi: 10.1038/s41392-018-0006-9. eCollection 2018. PMID: 29844933

Borrelia burgdorferi adhere to blood vessels in the dura mater and are associated with increased meningeal T cells during murine disseminated borreliosis. Divan A, Casselli T, Narayanan SA, Mukherjee S, Zawieja DC, Watt JA, Brissette CA, Newell-Rogers MK. PLoS One. 2018 May 3;13(5):e0196893. doi: 10.1371/journal.pone.0196893. eCollection 2018. PMID: 29723263

Primary Human Microglia Are Phagocytically Active and Respond to Borrelia burgdorferi With Upregulation of Chemokines and Cytokines. Greenmyer JR, Gaultney RA, Brissette CA, Watt JA. Front Microbiol. 2018 Apr 25;9:811. doi: 10.3389/fmicb.2018.00811. eCollection 2018. PMID: 29922241

Oral sensitization to whey proteins induces age- and sex-dependent behavioral abnormality and neuroinflammatory responses in a mouse model of food allergy: a potential role of mast cells. Germundson DL, Smith NA, Vendsel LP, Kelsch AV, Combs CK, Nagamoto-Combs K. J Neuroinflammation. 2018 Apr 23;15(1):120. doi: 10.1186/s12974-018-1146-0. PMID: 29685134

27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons. Schommer J, Marwarha G, Schommer T, Flick T, Lund J, Ghribi O. PMID:29614969

Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation. Khan N, Datta G, Geiger JD, Chen X. J Neuroinflammation. 2018 Mar 20;15(1):91. doi: 10.1186/s12974-018-1129-1. PMID: 29558961

A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset. Chin W, Zhong G, Pu Q, Yang C, Lou W, De Sessions PF, Periaswamy B, Lee A, Liang ZC, Ding X, Gao S, Chu CW, Bianco S, Bao C, Tong YW, Fan W, Wu M, Hedrick JL, Yang YY. Nat Commun. 2018 Mar 2;9(1):917. doi: 10.1038/s41467-018-03325-6. PMID:29500445

Exploration of the Anti-Inflammatory Drug Space Through Network Pharmacology: Applications for Drug Repurposing. de Anda-Jáuregui G, Guo K, McGregor BA, Hur J. Front Physiol. 2018 Mar 1;9:151. doi: 10.3389/fphys.2018.00151. eCollection 2018. PMID: 29545755

Tox21 Enricher: Web-based Chemical/Biological Functional Annotation Analysis Tool Based on Tox21 Toxicity Screening Platform. Hur J, Danes L, Hsieh JH, McGregor B, Krout D, Auerbach S. Mol Inform. 2018 May;37(5):e1700129. doi: 10.1002/minf.201700129. Epub 2018 Jan 29. PMID: 29377626

Student-teacher trust and journal-reader trust: Engines driving education and research in anatomical sciences. Pawlina W, Evans DJR, Chan LK, Ruit KG, Wilson TD, Lachman N. Anat Sci Educ. 2018 Jan;11(1):5-6. doi: 10.1002/ase.1767. PMID: 29314786

Patient Preferences for Surgery or Antibiotics for the Treatment of Acute Appendicitis. Hanson AL, Crosby RD, Basson M.D.. JAMA Surg. 2018 May 1;153(5):471-478. doi: 10.1001/jamasurg.2017.5310. PMID: 29322168

A New Year and a New Publishing Partnership With Wiley. Murphy EJ. Lipids. 2018 Jan;53(1):3-4. doi: 10.1002/lipd.12020. PMID: 29488639

2017 Publications

The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission. Sambo DO, Lin M, Owens A, Lebowitz JJ, Richardson B, Jagnarine DA, Shetty M, Rodriquez M, Alonge T, Ali M, Katz J, Yan L, Febo M, Henry LK, Bruijnzeel AW, Daws L, Khoshbouei H. Nat Commun. 2017 Dec 20;8(1):2228. doi: 10.1038/s41467-017-02087-x. PMID:29263318

Palmitoylation mechanisms in dopamine transporter regulation. Rastedt DE, Vaughan RA, Foster JD. J Chem Neuroanat. 2017 Oct;83-84:3-9. doi: 10.1016/j.jchemneu.2017.01.002. Epub 2017 Jan 20. Review. J Chem Neuroanat. 2017 PMID:28115272

Nucleosome positioning in the regulatory region of SV 40 chromatin correlates with the activation and repression of early and late transcription during infection. Kumar MA, Christensen K, Woods B, Dettlaff A, Perley D, Scheidegger A, Balakrishnan L, Milavetz B. Virology. 2017 Mar;503:62-69. doi: 10.1016/j.virol.2016.12.023. Epub 2017 Jan 23. Virology. 2017 PMID:28126638

MicroRNA and mRNA Transcriptome Profiling in Primary Human Astrocytes Infected with Borrelia burgdorferi. Casselli T, Qureshi H, Peterson E, Perley D, Blake E, Jokinen B, Abbas A, Nechaev S, WattJA, Dhasarathy A, Brissette CA. PLoS One. 2017 Jan 30;12(1):e0170961. doi: 10.1371/journal.pone.0170961. eCollection 2017. PLoS One. 2017 PMID:28135303 I PMCID:PMC5279786

Quantitation of Human Metallothionein Isoforms in Cells, Tissues, and Cerebrospinal Fluid by Mass Spectrometry. Shabb JB, Muhonen WW, Mehus AA. Methods Enzymol. 20 l 7;586:413-431. doi: 10.1016/bs.mie 2016.11.004. Epub 2016 Dec 7. Methods Enzymol. 2017 PMID:28137574

Effects of prenatal low protein and postnatal high fat diets on visceral adipose tissue macrophage phenotypes and IL-6 expression in Sprague Dawley rat offspring. Xie L, Zhang K, Rasmussen D, Wang}, Wu D, RoemmichJN, Bundy A, Johnson WT, Claycombe K. PLoS One. 2017 Jan 31;12(1):e0169581. doi: 10.1371/journal.pone 0169581. eCollection 2017. PLoS One. 2017 PMID:28141871 I PMCID:PMC5283658

Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies for Borrelia miyamotoi. Stone BL, Brissette CA. Front lmmunol. 2017 Jan 19;8: 12. doi: 10.3389/fimmu.2017.00012. eCollection 2017. Review. Front lmmunol. 2017 PMID:28154563 I PMCID:PMC5243832

Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation. Zhou L, Liu J, Xiang M, Olson P, Guzzetta A, Zhang K, Moskowitz IP, Xie L. Proc Natl Acad Sci US A. 2017 Feb 21;114(8):E1422-E1431. doi: 10.1073/pnas.1605137114. Epub 2017 Feb 6. Proc Nat!Acad Sci US A. 2017 PMID:28167794 I PMCID:PMC5338429

Histamine facilitates GABAergic transmission in the rat entorhinal cortex: Roles of H(l) and H(2) receptors, Na(+) -permeable cation channels, and inward rectifier K(+) channels. Cilz NI, Lei S. Hippocampus. 2017 May;27(5):613-631. doi: 10.1002/hipo.22718. Epub 2017 Feb 28. Hippocampus. 2017 PMID:28188663

Mincle regulates autophagy to control neutrophil extracellular trap formation. Sharma A, Simonson TJ, Jondle CN, Mishra BB, Sharma}. J Infect Dis. 2017 Feb 10. doi: 10.1093/infdis/jix072. [Epub ahead of print] No abstract available. J Infect Dis. 2017 PMID:28186242

Defining the contribution of neuroinflammation to Parkinson's disease in humanized immune system mice. Manocha GD, Floden AM, Puig KL, Nagamoto-Combs K, Scherzer CR, Combs CK. Mo! Neurodegener. 2017 Feb 14;12(1):17. doi: 10.1186/s13024-017-0158-z. Mo! Neurodegener. 2017 PMID:28196514 I PMCID:PMC5310074

Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation. WangX, Li Y, Luo D, WangX, Zhang Y, Liu Z, Zhong N, Wu M, Li G. Sci Rep. 2017 Feb 16;7:42675. doi: 10.1038/srep42675. Sci Rep. 2017 PMID:28205598 I PMCID:PMC5312001

DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia. Ye Y, Lin P, Zhang W, Tan S, Zhou X, Li R, Pu Q, KoffJL, Dhasarathy A, Ma F, DengX, Jiang}, Wu M. J lmmunol. 2017 Apr 1;198(7):2844-2853. doi: 10.4049/jimmunol.1601001. Epub 2017 Feb 15. J lmmunol. 2017 PMID:28202616 I PMCID:PMC5360514

A summary of the Proceedings of the Thirteenth International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 17-22, 2016. Brown-Borg HM, Borg KE. Exp Gerontol. 2017 Feb 16. pii: S0531-5565(17)30108-0. doi: 10.1016/j.exger.2017.02.005. [Epub ahead of print] Exp Gerontol. 2017 PMID:28216411

Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis. Pu Q, Gan C, Li R, Li Y, Tan S, Li X, Wei Y, Lan L, Deng X, Liang H, Ma F, Wu M. J lmmunol. 2017 Apr 15;198(8):3205-3213. doi: 10.4049/jimmunol.1601196. Epub 2017 Mar 3. J lmmunol. 2017 PMID:28258192 I PMCID:PMC5382979

Inhibition of L-Type Ca(2+) Channels by TRPCl-STIMl Complex Is Essential for the Protection of Dopaminergic Neurons. Sun Y, Zhang H, Selvaraj S, Sukumaran P, Lei S, Birnbaumer L, Singh BB. J Neurosci. 2017 Mar 22;37(12):3364-3377. doi: 10.1523/JNEUROSCl.3010-16.2017. Epub 2017 Mar 3. J Neurosci. 2017 PMID:28258168 I PMCID:PMC5373123

Prediction of Gestational Diabetes Mellitus by Unconjugated Estriol Levels in Maternal Serum. Hur J, Cho EH, Baek KH, Lee KJ. lntJ Med Sci. 2017 Feb 7;14(2):123-127. doi: 10.7150/ijms.17321. eCollection 2017. lnt J Med Sci. 2017 PMID:28260987 I PMCID:PMC5332840

Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain. Puig KL, Brose SA, Zhou X, Sens MA, Combs GF, Jensen MD, Golovko MY, Combs CK. Sci Rep. 2017 Mar 6;7:43725. doi: 10.1038/srep43725. Sci Rep. 2017 PMID:28262782 I PMCID:PMC5338020

Comparative RNA-Seq transcriptome analyses reveal distinct metabolic pathways in diabetic nerve and kidney disease. Hinder LM, Park M, Rumora AE, Hur J, Eichinger F, Pennathur S, Kretzler M, Brosius FC 3rd, Feldman EL. J ell Mo! Med. 2017 Sep;21(9):2140-2152. doi: 10.1111/jcmm.13136. Epub 2017 Mar 8. J Cell Mo! Med. 2017 PMID:28272773 I PMCID:PMC5571536

Ontology-based literature mining of E. coli vaccine-associated gene interaction networks. Hur J, A-zgAl/.ir A, He Y. J Biomed Semantics. 2017 Mar 14;8(1):12. doi: 10.1186/s13326-0I7-0122-4. J Biomed Semantics. 2017 PMID:282886851 PMCID:PMC5348867

Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltrans­ferase Zhang LQ, Van Haandel L, Xiong M, Huang P, Heruth DP, Bi C, Gaedigk R, Jiang X, Li DY, WyckoffG, Grigoryev DN, Gao L, Li L, Wu M, Leeder JS, Ye SQ. Cell Death Dis. 017 Mar 23;8(3):e2705. doi: 10.1038/cddis.2017.132. Cell Death Dis. 2017 PMID:28333140

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions. Cole JJ, Robertson NA, Rather MI, Thomson JP, McBryan T, Sproul D, WangT, Brock C, Clark W, IdekerT, Meehan RR, Miller RA, Brown-Borg HM, Adams PD. Genome Biol. 2017 Mar 28;18(1):58. doi: 10.1186/s13059-017-1185-3. Genome Biol. 2017 PMID:28351383 I PMCID:PMC5370462

Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment. Wang T, Tsui B, Kreisberg JF, Robertson NA, Gross AM, Yu MK, Carter H, Brown-Borg HM, Adams PD, Ideker T. Genome Biol. 2017 Mar 28;18(1):57. doi: 10.1186/s13059-0I7-1186-2. Genome Biol. 2017 PMID:28351423 I PMCID:PMC5371228

Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis. Chevalier AC, Rosenberger TA. J Neurochem. 2017 Jun; 141 (5):721-737. doi: 10.1111/jnc. l 4032. Epub 2017 May 2. J Neurochem. 2017 PMID:28369944

The blood-brain barrier and protein-mediated fatty acid uptake: role of the blood-brain barrier as a metabolic barrier: An Editorial Comment for 'The blood-brain barrier fatty acid transport protein 1 (FATPI/SLC27 Al) supplies docosahexaenoic acid to the brain, and insulin facilitates transport'. Murphy EJ. J Neurochem. 2017 May;I41(3):324-329. doi: 10.1111/jnc.14000. Epub 2017 Mar 30. J Neurochem. 2017 PMID:28369884

Pre-Pregnancy Body Mass Index Is Associated with Dietary Inflammatory Index and C-Reactive Protein Concentrations during Pregnancy. Shin D, Hur J, Cho EH, Chung HK, Shivappa N, Wirth MD, Hébert JR, Lee KW Nutrients. 2017 Apr 1;9(4). pii: E35I. doi: 10.3390/nu904035I. Nutrients. 2017 PMID:28368304 I PMCID:PMC5409690

Comparative effects of high oleic acid vs high mixed saturated fatty acid obesogenic diets upon PUFA metabolism in mice. Picklo MJ Sr, Idso J, Seeger DR, Aukema HM, Murphy EJ. Prostaglandins Leukot Essent Fatty Acids. 2017 Apr;l 19:25-37. doi: 10.1016/j.plefa.2017.03.001. Epub 2017 Mar 8. Prostaglandins Leukot Essent Fatty Acids. 2017 PMID:28410667

Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring. Marwarha G, Claycombe-Larson K, Schommer J, Ghribi 0. J Nutr Biochem. 2017 Jul;45:54-66. doi: 10.1016/j.jnutbio.2017.03.005. Epub 2017 Apr 6. J Nutr Biochem. 2017 PMID:28432877 I PMCID:PMC5466833

So You Want to Publish in Lipids: Tips for Authors to Enhance Their Potential for Success. Murphy EJ. Lipids. 2017 Apr 28. doi: 10.1007/sl1745-0I7-4255-0. [Epub ahead of print] No abstract available. Lipids. 2017 PMID:28455684

Method for organotypic tissue culture in the aged animal. Schommer J, Schrag M, Nackenoff A, Marwarha G, Ghribi 0. MethodsX. 2017 Apr 7;4:166-171. doi: 10.1016/j.mex.2017.03.003. eCollection 2017. MethodsX. 2017 PMID:28462173 I PMCID:PMC5403786

Nuclear Localizing Peptide-Conjugated, Redox-Sensitive Polymersomes for Delivering Curcumin and Doxorubicin to Pancreatic Cancer Microtumors. Anajafi T, Yu J, Sedigh A, Haldar MK, Muhonen WW, Oberlander S, Wasness H, Froberg], Molla MS, Katti KS, Choi Y, Shabb JB, Srivastava DK, Mallik S. Mol Pharm. 2017 Jun 5;14(6):1916-1928. doi: 10.102I/acs.molpharmaceut.7b00014. Epub 2017 May 22. Mol Pharm. 2017 PMID:28493710

Potential of a Northern Population of Aedes vexans (Diptera: Culicidae) to Transmit Zika Virus. O'Donnell KL, Bixby MA, Morin KJ, Bradley DS, Vaughan JA. J Med Entomol. 2017 May 12. doi: 10.I093/jme/tjx087. [Epub ahead of print] J Med Entomol. 2017 PMID:28499036

The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERI2 in prostate cancer cells. Raza S, Meyer M, Goodyear C, Hammer KDP, Guo B, Ghribi 0. Cancer Cell Int. 2017 May 11;17:52. doi: 10.1186/s12935-0I7-0422-x. eCollection 2017. Cancer Cell Int. 2017 PMID:28503095 I PMCID:PMC5425984

NFATc2 Modulates Microglial Activation in the AI2PP/PSI Mouse Model of Alzheimer's Disease. Manocha GD, Ghatak A, Puig KL, Kraner SD, Norris CM, Combs CK. J Alzheimers Dis. 2017 May 8. doi: 10.3233/JAD-151203. [Epub ahead of print] J Alzheimers Dis. 2017 PMID:28505967

Graphene oxide as an efficient antimicrobial nanomaterial for eradicating multi-drug resistant bacteria in vitro and in vivo. Wu X, Tan S, Xing Y, Pu Q, Wu M, Zhao JX. Colloids Surf B Biointerfaces. 2017 May 17; 157: 1-9. doi: 10.1016/j.colsurfb.2017.05.024. [Epub ahead of print] Colloids Surf B Bio­ interfaces. 2017 PMID:28554055

Somatostatin depresses the excitability of subicular bursting cells: Roles of inward rectifier K( +) channels, KCNQ channels and Epac. Hu B, Cilz NI, Lei S. Hippocampus. 2017 May 30. doi: 10.1002/hipo.22744. [Epub ahead of print] Hippocampus. 2017 PMID:28558129

Alternate binding modes of anti-CRISPR viral suppressors AcrFI/2 to Csy surveillance complex revealed by cryo-EM structures. Peng R, Xu Y, Zhu T, Li N, Qi J, Chai Y, Wu M, Zhang X, Shi Y, Wang P, Wang J, Gao N, Gao GE Cell Res. 2017 Jul;27(7):853-864. doi: 10.1038/cr.2017.79. Epub 2017 Jun 2. Cell Res. 2017 PMID:28574055

27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. Marwarha G, Raza S, Hammer K, Ghribi 0. Chem Phys Lipids. 2017 Jun 3. pii: S0009-3084(17)30037-3. doi: 10.1016/j.chemphyslip. 2017.05.012. [Epub ahead of print] Review. Chem Phys Lipids. 2017 PMID:28583434 

Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. Simmler LO, Anacker AMJ, Levin MH, Vaswani NM, Gresch PJ, Nackenoff AG, Anastasio NC, Stutz SJ, Cunningham KA, Wang J, Zhang B, Henry LK, Stewart A, Veenstra-VanderWeele J, Blakely RD. Br J Pharmacol. 2017 Aug;! 7 4(16) :2716-2738. doi: 10.1111/bph.13899. Epub 2017 Jul 11. Br J Pharmacol. 2017 PMID:28585320 

An Ethical Dilemma: To Share or Not To Share Your Paper Published in Lipids Using an On-Line Outlet. Murphy EJ. Lipids. 2017 Jul;52{7):573-574. doi: 10.1007/sl 1745-017-4268-8. No abstract available. Lipids. 2017 PMID:28603809

Sickle Cells Produce Functional Immune Modulators and Cytotoxics. Sun CW, Wu LC, Knopick PL, Bradley OS, TownesT, Terman OS. Am] Hemacol. 2017 Jun 24. doi: 10.1002/ajh.24836. [Epub ahead of print] Am] Hemacol. 2017 PMID:28646491

Dengue virus specific IgY provides protection following lethal dengue virus challenge and is neutralizing in the absence of inducing antibody dependent enhancement. Fink AL, Williams KL, Harris E, Alvine TD, Henderson T, Schiltz], Nilles ML, Bradley OS. PLoS Neg! Trop Dis. 2017 Jul 7;11 (7):e0005721. doi: 10.1371/journal.pntd.0005721. eCollection 2017 Jul. PLoS Negl Trop Dis. 2017 PMID:28686617

Response to Comment on "DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia". Ye Y, Lin P, Zhang W, Tan S, Zhou X, Li R, Pu Q, Koff JL, Dhasarathy A, Ma F, Deng X, Jiang], Wu M. J Immunol. 2017 Jul 15;199(2):381-382. doi: 10.4049/jimmunol.1700676. No abstract available. J Immunol. 2017 PMID:28696327

Amyloid precursor protein in pancreatic islets. Kulas J, Puig K, Combs CK. J Endocrinol. 2017 Jul 14. pii: JOE-17-0122. doi: 10.1530/JOE-17-0122. [Epub ahead of print] J Endocrinol. 2017 PMID:28710249

Assessment of the DNA damaging potential of environmental chemicals using a quantitative high-throughput screening approach to measure p53 activation. Wice KL, Hsieh JH, Smith-Roe SL, Xia M, Huang R, Zhao J, Auerbach SS, Hur J, Tice RR. Environ Mol Mutagen. 2017 Aug;58(7):494-507. doi: 10.1002/em.22112. Epub 2017 Jul 17. Environ Mol Mutagen. 2017 PMID:28714573 I PMCID:PMC5555817

Brave New Worlds: The Expanding Universe of Lyme Disease. Stone BL, Tourand Y, Brissette CA. Vecror Borne Zoonotic Dis. 2017 Sep;l7(9):619-629. doi: 10.1089/vbz.2017.2127. Epub 2017 Jul 20. Review. Vector Borne Zoonocic Dis. 2017 PMID:28727515 I PMCID:PMC5576071

Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs. Krout D, Pramod AB, Dahal RA, Tomlinson MJ, Sharma B, Foster JD, Zou MF, Boa tang C, Newman AH, Lever JR, Vaughan RA, Henry LK. Biochem Pharmacol. 2017 Jul 19. pii: S0006-2952(17)30492-6. doi: 10.1016/j.bcp.2017.07.015. [Epub ahead of print] Biochem Pharmacol. 2017 PMID:28734777

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease. Ghribi 0. CNS Neurol Disord Drug Targets. 2017 Jul 25. doi: 10.2174/1871527316666170725 l 14652. [Epub ahead of print] CNS Neurol Disord Drug Targets. 2017 PMID:287 45240

Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation. Guo X, Shu C, Li H, Pei Y, Woo SL, Zheng J, Liu M, Xu H, Bocchlecc R, Guo T, Cai Y, Gao X, Zhou J, Chen L, Li Q, Xiao X, Xie L, Zhang KK, Ji JY, Huo Y, Meng F, Alpini G, et al. Sci Rep. 2017 Jul 25;7(1):6355. doi: 10.1038/s41598-017-05884-y. Sci Rep. 2017 PMID:28743914

An IDeA for enhancing undergraduate research at rural primarily undergraduate institutions. Sens DA, Cisek KL, Conway P, Doze VA. Adv Physiol Educ. 2017 Sep 1;41(3):464-471. doi: 10.l 152/advan.00041.2017. Adv Physiol Educ. 2017 PMID:28743692

Epigenetic Analysis of SV 40 Minichromosomes. Balakrishnan L, Milavetz B. Curr Protoc Micro biol. 2017 Aug 11;46:14F.3.l-14F.3.26. doi: 10.1002/cpmc.35. Curr Protoc Microbial. 2017 PMID:28800155

Disentangling High Fat, Low Carb, and Healthy Aging. Brown-Borg HM. Cell Metab. 2017 Sep 5;26(3):458-459. doi: 10.1016/j.cmec.2017.08.020. Cell Metab. 2017 PMID:28877453

The conformational epitope for a new AB42 protofibril-selective antibody partially overlaps with the peptide N-terminal region. Colvin BA, Rogers VA, Kulas JA, Ridgway EA, Amcashar FS, Combs CK, Nichols MR. J Neurochem. 2017 Sep 7. doi: 10.1111/jnc.1421 l. [Epub ahead of print) J Neurochem. 2017 PMID:28881033

Metabolic adventures in aging research. Brown-Borg HM, Anderson RM. Mol Cell Endocrinol. 2017 Nov 5 455:1-3. doi: 10.1016/j.mce.2017.08.012. No abstract available. Mol Cell Endocrinol. 2017 PMID:28888245

Identification of novel non-ionic, cationic, zwitcerionic, and anionic polyfluoroalkyl substances using UPLC-TOF-MS(E) high-resolution parent ion search. Xiao F, Golovko SA, Golovko MY. Anal Chim Acea. 2017 Oct 2;988:41-49. doi:10.1016/j.aca.2017.08.016. Epub 2017 Aug 22. Anal Chim Acea. 2017 PMID:28916102

Dopamine Transporter Phosphorylation Site Threonine 53 is Stimulated by Amphetamines and Regulates Dopamine Transport, Effiux, and Cocaine Analog Binding. Challasivakanaka S, Zhen J, Smith ME, Reich MEA, Foster JD, Vaughan RA. J Biol Chem. 2017 Sep 22. pii: jbc.Ml 17.787002. doi: 10.1074/jbc.Ml 17.787002. [Epub ahead of print] J Biol Chem. 2017 PMID:28939767

Ether lipids and their elusive function in the nervous system: a role for plasmalogens: An Editorial Highlight for 'Reduced muscle strength in ether lipid-deficient mice is accompanied by altered development and function of the neuromuscular junction' on page569: 10.1111/jnc.14082. Murphy EJ. J Neurochem. 2017 Sep 25. doi: 10.1111/jnc.14156. [Epub ahead of print) J Neurochem. 2017 PMID:28944460

STEERing an IDeA in Undergraduate Research at a Rural Research Intensive University. Sens DA, Cisek KL, Garrett SH, Somji S, Dunlevy JR, Sens MA, Conway P, Doze VA. Acad Pathol. 2017 Oct 13;4:2374289517735092. doi: 10. l l 77/2374289517735092. eCollection 2017 Jan-Dec. Acad Pathol. 2017 PMID:29057317 I PMCID:PMC5642003

A protocol for preparation and transfection of rat entorhinal cortex organotypic cultures for electrophysiological whole-cell recordings. Cilz NI, Porter JE, Lei S. MethodsX. 2017 Oct 18;4:360-371. doi: 10.1016/j.mex.2017.10.003 eCollection 2017. MethodsX. 2017 PMID:29071214 I PMCID:PMC5651549

Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AI CD induction of MAST 4 abundance and kinase activity. Gongol B, Marin TL, Jeppson JD, Mayagoitia K, Shin S, Sanchez N, Kirsch WM, Vinters HY, Wilson CG, Ghribi 0, Soriano S. Sci Rep. 2017 Oct 24;7(1):13898. doi: 10.1038/s41598-0l 7-13933-9. Sci Rep. 2017 PMID:29066835 I PMCID:PMC5654999

Advances in omics for informed pharmaceutical research and development in the era of systems medicine. Bai JPF, Melas IN, Hur J, Guo E. Expert Opin Drug Discov. 2017 Oct 27:1-4. doi: 10.1080/17460441.2018.1394839. <[Epub ahead of print] No abstract available. Expert Opin Drug Discov. 2017 PMID:29073782

The TRPCl Ca(2+)-permeable channel inhibits exercise-induced protection against high-fat diet-induced obesity and type II diabetes. Krout D, Schaar A, Sun Y, Sukumaran P, Roemmich JN, Singh BB, Claycombe-Larson KJ. J Biol Chem. 2017 Dec l 5;292(50):20799-20807. doi: 10.1074/jbc.Ml 17.809954. Epub 2017 Oct 26. J Biol Chem. 2017 PMID:29074621 I PMCID:PMC5733613

Prevalences and Management of Diabetes and Pre-diabetes among Korean Teenagers and Young Adults: Results from the Korea National Health and Nutrition Examination Survey 2005-2014. Cho EH, Shin D, Cho KH, Hur J. J Korean Med Sci. 2017 Dec;32(12):1984-1990. doi: 10.3346/jkms.2017.32.12.1984. J Korean Med Sci. 2017 PMID:29115080 I PMCID:PMC5680497

The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis. Brandimarti R, Hill GS, Geiger JD, Meucci 0. Sci Rep. 2017 Nov 8;7(1):15103. doi: 10.1038/s41598-017-15128-8. Sci Rep. 2017 PMID:29118375 I PMCID:PMC5678071

Epigenetic Regulation of Viral Biological Processes. Balakrishnan L, Milavetz B. Viruses. 2017 Nov 17;9(1 l). pii: E346. doi: 10.3390/v9 l l 0346. Review. Viruses. 2017 PMID:29149060

Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux. Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Peng Y, Nice EC, Wu M, Huang C, Wei Y. Autophagy. 2017 Nov 26:1-56. doi: 10.1080/15548627.2017.1409405. [Epub ahead of print] Autophagy. 2017 PMID:29172997

Corrigendum to "The external gate of the human and Drosophila serotonin transporters requires a basic/acidic amino acid pair for 3,4-methylenedioxymethamphetamine (MOMA) translocation and the induction of substrate efflux" [Biochem. Pharmacol. 120 (2016) 46-55]. Sealover NR, Felts B, Kuntz CP, Jarrard RE, Hockerman GH, Lamb PW, Barker EL, Henry LK. Biochem Pharmacol. 2017 Nov 28;147:9. doi: 10.1016/j.bcp.2017.11.001. [Epub ahead of print] No abstract available. Biochem Pharmacol. 2017 PMID:29195124

The sigma-I receptor modulates methamphetamine dysregulation of dopamine neurotransmission. Sambo DO, Lin M, Owens A, Lebowicz JJ, Richardson B, Jagnarine DA, Shetty M, Rodriquez M, AlongeT, Ali M, KaczJ, Yan L, Febo M, Henry LK, BruijnzeelAW, Daws L, Khoshbouei H. Nat Commun. 2017 Dec 20;8(1):2228. doi: 10.1038/s41467-017-02087-x. Nat Commun. 2017 PMID:29263318 I PMCID:PMC5738444

A novel role for the macrophage galactose-type lectin (MGL) receptor in mediating von Willebrand factor clearance. Ward SE, O'Sullivan JM, Drakeford C, Aguila S, Jondle CN, Sharma J, Fallon PG, Brophy TM, Preston RJS, Smyth P, Sheils 0, Chion A, O'Donnell JS. Blood. 2017 Dec 27. pii: blood-2017-06-787853. doi: 10.1182/blood-2017-06-787853. [Epub ahead of print] Blood. 2017 PMID:29282218