Publications

2018

Krout D, Roemmich JN, Bundy A, Garcia RA, Yan L, and Claycombe-Larson KJ (2018) Paternal exercise protects mouse offspring from high-fat-diet-induced type 2 diabetes risk by increasing skeletal muscle insulin signaling. The Journal of nutritional biochemistry 57:35-44. ScienceDirect
Jahns L, Conrad Z, Johnson LK, Whigham LD, Wu D, and Claycombe-Larson KJ (2018) A diet high in carotenoid-rich vegetables and fruits favorably impacts inflammation status by increasing plasma concentrations of IFN-alpha2 and decreasing MIP-1beta and TNF-alpha in healthy individuals during a controlled feeding trial. Nutrition research 52:98-104.

2017

Krout D, Schaar A, Sun Y, Sukumaran P, Roemmich JN, Singh BB, and Claycombe-Larson KJ (2017) The TRPC1 Ca(2+)-permeable channel inhibits exercise-induced protection against high-fat diet-induced obesity and type II diabetes. The Journal of biological chemistry 292:20799-20807. PubMed
Marwarha G, Claycombe-Larson K, Schommer J, and Ghribi O (2017) Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring. The Journal of nutritional biochemistry 45:54-66. PubMed

2016

Claycombe KJ, Vomhof-DeKrey EE, Garcia, Johnson WT, Uthus E, and Roemmich JN (2016) Decreased beige adipocyte number and mitochondrial respiration coincide with reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat diets, J Nutr. Biochem, 113: 113-121. PubMed
Dhasarathy A, Roemmich JN, and Claycombe KJ (2016) Influence of Maternal Obesity, Diet and Exercise on Epigenetic Regulation of Adipocytes, In review, Molecular Aspects of Medicine. ScienceDirect
Vomhof-DeKrey E, Roemmich J, and Claycombe K (2016) Maternal low protein diet leads to placental angiogenic compensation via dysregulated M1/M2 macrophages and TNFα expression in Sprague-Dawley rats, In revision, Journal of Reproductive Immunology. PubMed
Garcia RA, Roemmich JN, and Claycombe KJ (2016) Evaluation of Markers of Beige Adipocytes in White Adipose Tissue of the Mouse, Nutr and Metabolism, 18;13:24. BioMed

2015

Zeng H, Claycombe K, and Reindl K (2015) Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation, J Nutritional Biochem., In press, July 2015. PubMed
Claycombe K, Vomhof-DeKrey EE, Roemmich JN,Rhen T, and Ghribi O (2015) Maternal low protein diet causes body weight loss in male, neonate Sprague-Dawley rats involving UCP-1 mediated thermogenesis, In press, , J Nutritional Biochem., 26:729-35. PubMed
Claycombe KJ, Roemmich JN, Johnson L, Vomhof-DeKrey EE, and Johnson WT (2015) Skeletal muscle Sirt3 expression and mitochondrial respiration are regulated by a prenatal low protein diet, 26(2):184-189, J Nutritional Biochem. PubMed
Claycombe KJ, Brissette CA, and Ghribi O (2015) Epigenetics of Inflammation, Maternal Infection, and Nutrition. Journal of Nutr., 145(5): 1109S-1115S. PubMed
Stephensen CB, Dawson HD, and Claycombe KJ (2015) Impact of nutrition on immune function and the inflammatory response. Journal of Nutr., 145(5):1039S-1108S. PubMed
Zeng H, Claycombe K, and Reindl K (2015) Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation, J Nutritional Biochem., In press, July 2015. PubMed
Claycombe K, Vomhof-DeKrey EE, Roemmich JN, Rhen T, and Ghribi O (2015) Maternal low protein diet causes body weight loss in male, neonate Sprague-Dawley rats involving UCP-1 mediated thermogenesis, In press, J Nutritional Biochem., 26:729-35. PubMed
Claycombe KJ, Roemmich JN, Johnson L, Vomhof-DeKrey EE, and Johnson WT (2015) Skeletal muscle Sirt3 expression and mitochondrial respiration are regulated by a prenatal low protein diet, 26(2):184-189, J Nutritional Biochem. PubMed

2013-2014

Martinez JA, Milagro FI, Claycombe KJ, and Schalinske KL (2014) Epigenetics in adipose tissue, obesity, weight loss, and diabetes. Adv Nutr., 5:71-81. PubMed
Choi SW, Claycombe KJ, Martinez JA, Friso S, and Schalinske KL (2013) Nutritional epigenomics: a portal to disease prevention. Adv Nutr. 2013;4:530-2. ResearchGate
Yan L, Graef GL, Claycombe KJ, and Johnson LK (2013) Effects of voluntary running and soy supplementation on diet-induced metabolic disturbance and inflammation in mice. J Agric Food Chem., 61:9373-9. PubMed
Claycombe KJ, Uthus EO, Roemmich JN, Johnson LK, and Johnson WT (2013) Prenatal Low-Protein and Postnatal High-Fat Diets Induce Rapid Adipose Tissue Growth by Inducing Igf2 Expression in Sprague Dawley Rat Offspring. J Nutr. 143 (10): 1533-1539. PubMed

2012

Zhou Z, Nepune M, Zhou HR, Wu D, Moustaid-Moussa N, and Claycombe KJ (2012) Signal transducer and activator of transcription 3 (stat3) is differentially regulated under basal and leptin-stimulated conditions in the adipose CD34+ cell. In press, Nutr Metab, December 2012. NCBI
Picklo M,Claycombe KJ, and Meydani M (2012) Adipose dysfunction, interaction of reactive oxygen species and inflammation. Adv. Nutr. 3(5):734-735. Advances in Nutrition
Zhou Z, Nair M, and Claycombe KJ (2012) Synergistic inhibition of interleukin-6 production in adipose stem cells by tart cherry anthocyanins and atorvastatin, Phytomedicine, 19(10): 878-881. PubMed
Siriwardhana N, Kalupahana NS, Fletcher S, Xin W, Claycombe KJ, Zhao L, Saxton AM, Quignard-Boulange A, and Moustaid-Moussa N (2012) N-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines, in part via NF-kB dependent mechanisms, J Nutr Biochem. 23(12): 1661-1667. PubMed
Kalupahana NS, Moustaid-Moussa N, and Claycombe KJ (2012) Immunity as a link between obesity and insulin resistance. Mol Aspects Med. 33:26-34. PubMed

2011

Kalupahana NS,Claycombe KJ, and Moustaid-Moussa N (2011) (n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights, Adv Nutr, 2(4): 304-316. PubMed
Hsueh HW, Zhou Z, Whelan J, Allen KG, Moustaid-Moussa N, Kim H ,and Claycombe KJ (2011) Stearidonic and eicosapentaenoic acids inhibit interleukin-6 expression in ob/ob mouse adipose stem cells via Toll-like receptor-2-mediated pathways. J Nutr. 141:1260-6. PubMed

2009-2010

Kalupahana NS, Claycombe KJ, Newman SJ, Stewart T, Siriwardhana N, Matthan N, Lichtenstein AH, and Moustaid-Moussa N (2010) Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. J Nutr. 140:1915-22. PubMed
Shin AC, MohanKumar SM, Sirivelu MP,Claycombe KJ, Haywood JR, Fink GD, and MohanKumar PS (2010) Chronic exposure to a high-fat diet affects stress axis function differentially in diet-induced obese and diet-resistant rats. Int J Obes, 34:1218-26. PubMed
Han D, Yang B, Olson LK, Greenstein A, Baek SH, Claycombe KJ, Goudreau JL, Yu SW, and Kim EK (2009) Activation of autophagy through modulation of AMP-activated protein kinase protects pancreatic beta-cells from hyperglycemia, Biochem J, 425: 541-55. Biochem Journal
Wortman P, Miyazaki Y, Kalupahana NS, Kim S, Hansen-Petrik M, Saxton AM, Claycombe KJ, Voy BH, Whelan J, and Moustaid-Moussa N (2009) N-3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes., Nutr Metab. 6:5. PubMed

2007-2008

Aziz K, Berger K, Claycombe KJ, Ma H, Huang R, Patel R, and Abela GS (2008) Noninvasive detection and localization of vulnerable plaque and arterial thrombosis using CTA/PET, Circulation. 117: 2061-2070, 8. Circulation
Claycombe K, King L, and Fraker P (2008) A role for leptin in sustaining lymphopoiesis and myelopoiesis. PNAS. 105: 2017-2021. PubMed
Chun OK, Chung SJ, Claycombe KJ, and Song WO (2008) Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults, J. Nutr. 138: 753-760. PubMed
Zhou HR, Kim EK, Kim H, and Claycombe KJ (2007) Obesity -associated mouse adipose stem cell secretion of monocyte chemotactic protein-1 (MCP-1), Am. J. Physiol. 293: E1153- 1158. American Journal of Physiology

2003-2004

Harkins JM, Moustaid-Moussa N, Penner KM, Pestka JJ, Chung YJ, North CM, and Claycombe KJ (2004) Expression of interleukin-6 is greater in preadipocytes than in adipocytes of 3T3-L1 cells and C57BL/6J and ob/ob mice. J Nutr. 134: 2673-2677. PubMed
Wang Y, Jones Voy B, Urs S, Kim S, Soltani-Bejnood M, Quigley N, Heo YR, Standridge M, Andersen B, Dhar M, Joshi R, Wortman P, Taylor JW, Chun J, Leuze M, Claycombe K, Saxton AM, and Moustaid-Moussa N (2004) The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue. J. Nutr. 134: 1032-1038. PubMed
Wu D, Marko M, Claycombe K, Paulson KE, and Meydani SN (2003) Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediated through upregulation of NF- kappa B activity. J Biol Chem. 278: 0983-10992. PubMed

2001-2002

Heo YR, Claycombe K, Jones BH, Wright P, Truett GE, Zemel M, Banz W, Maher M, and Moustaid-Moussa N (2002) Effects of Fatty (fa) Allele and High-Fat Diet on Adipose Tissue Leptin and Lipid Metabolism. Horm Metab Res. 34: 686-690. PubMed
Claycombe KJ, Wu D, and Meydani SN (2002) Eicosanoids and immune function in the aged: dietary modification. Pro. Int. Con. Essen. Fatty Acids and Eicosanoids. 1: 227-229.
Claycombe KJ, Wu D, Palmer H, Nikolova-Karakashian M, Merrill Jr. AH, Paulson E, and Meydani SN (2002) Age-associated increase in macrophage (Mø) cyclooxygenase-2 (cox-2) expression is mediated by ceramide. J. Biol. Chem. 277: 30784-30791. PubMed
Kim S, Whelan J, Claycombe K, Taylor J, and Moustaid-Moussa N (2002) Angiotensin II increases leptin secretion by adipocytes via a prostaglandin-independent mechanism. J Nutr. 132: 1135-1140. PubMed
Koga T, Claycombe KJ, and Meydani M (2002) Homocysteine increases monocyte and T cell adhesion to human aortic endothelial cells. Atherosclerosis. 16: 365-374. PubMed
Kim S, Dugail I, Standridge M, Claycombe K, Chun J, and Moustaid-Moussa N (2001) Angiotensin II- responsive element is the insulin-responsive element in the adipocyte fatty acid synthase gene: role of adipocyte determination and differentiation factor 1/sterol-regulatory-element-binding protein 1c. Biochem J. 357: 899-890. PubMed
Claycombe KJ and Meydani SN (2001) Vitamin E and genome stability. Mutat Res. 475:37-44. ScienceDirect

1999-2000

Claycombe KJ, Jones BH, Guo Y, Wilkison WO, Zemel MB, Chun J, and Moustaid N (2000) Transcriptional regulation of the adipocyte fatty acid synthase gene by the agouti gene products: interaction with insulin. Physiol. Genom. 3: 157-162. American Physiological Society
Claycombe KJ, Xue B, Maynatte RL, Zemel MB, and Moustaid-Moussa N (2000) Regulation of leptin by insulin and agouti. Physiol. Genom. 2: 101-105. PubMed
Moustaid-Moussa N and Claycombe KJ (1999) The yellow mouse obesity syndrome and mechanism of agouti-induced obesity. Obe. Res. 7:506-514. PubMed
Jones BH, Standridge MK, Claycombe KJ, Smith PJ, and Moustaid-Moussa N (1998) Glucose induces expression of stearoyl-CoA desaturase in 3T3-L1 adipocytes. Biochem. J. 335: 405-408, 9. PubMed

1995-1998

Claycombe KJ, Jones BH, Standridge MK, Guo Y, Chun JT, Taylor JW, and Moustaid-Moussa N (1998) Insulin increases fatty acid synthase gene transcription in human adipocytes. Am. J. Physiol. 274: R1253-R1259. PubMed
Mancuso P, Whelan J, DeMichele SJ, Snider CC, Guszcza JA, Claycombe KJ, Smith GT, Gregory TJ, and Karlstad M. (1997) Effects of eicosapentaenoic and gammalinolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats. Crit. Care. Med. 25: 523-532. PubMed
Claycombe KJ, Lee DW, and Miller HA (1995) Proportions of rat ANP-secreting cells that are cardiomyocytes and that synthesize the hormone. Am. J. Physiol. 268: H265-270. PubMed

Additional Publications

Book chapters

Kate J. Claycombe, Hauwei Zeng, Gerald F Combs, Nutrition and Epigenetics, 2015 (Chapter 12), Dietary Effects on Adipocyte metabolism and Epigenetic, CRC Press, Boca Raton, FL.
Meydani SN, Claycombe KJ, Sacristan C. Vitamin E and gene expression. 2001 (Chapter 16) 393-424. Nutrition-Gene Interactions in Health & Disease. (1st Edition, Modern Nutrition Series), CRC Press, Boca Raton, FL.

Bulletins

Claycombe KJ. 2004 “C-reactive protein, Obesity and Immune System”, MAES/M.S.U
Claycombe KJ, 2005 “Montmorency tart cherries: The healing fruit”, Cherry Marketing Institute
Claycombe KJ, 2008 “Researchers make discoveries on what does and does not affect immune system”, M.S.U News Bulletin Newspaper article Chicago Tribune article. "Salmon Dilemma, With higher PCB levels showing up in farmed variety, are the health benefits worth the risk?", Interviewed and quoted in the article, January 28, 2004.

Press Release

“Effects of Cherry Flavonoids on Cardiovascular Disease Biomarkers”, Quoted in the press conference during the National Cherry Festival by Cherry Marketing Institute, Traverse City, Michigan, April 2004.