Kurt Zhang, Ph.D.
Director of ND INBRE Bioinformatics Core
Our research is focused on elucidating the molecular and genetic mechanisms underlying pathological processes using genomic studies. We employ the cutting-edge high-throughput technology such as next-generation sequencing, proteomics and microarray chips to conduct systems biology studies. A major effort in our lab has been devoted to develop advanced computer algorithms and statistical methods for bioinformatics research.
Our research areas include:
Cancer genomics: identification of cancer biomarkers and development of new genetic tests for early diagnosis and prognosis.
Gene regulatory networks: understanding the gene-gene interactions in development and disease progression.
Clinical trials: conducting multiple pre-clinical and clinical trials for cancer and infectious diseases.
Transcriptome assembly: development of a novel de novo assembly algorithm for RNA-Seq data.
Our hardware includes:
Dell PowerEdge M1000e blade chassis with 16 M520 blade servers
Dell PowerEdge R910 rack server with 512 GB RAM and 100 TB disk storage space
Two Dell PowerEdge R420 rack servers
Our software includes:
- Gene set enrichment analysis for longitudinal expression profiles (longiGSEA)
- DNA segmentation using a novel nonparametric method
- Tumor subtype classification using a non-negative matrix decomposition method for DNA copy numbers
- Tumor subtype classification using a hidden Markov model for DNA copy numbers
- Biomarker cutoff determination for survival data
All software packages are available to academic users. If you wish to use the software for commercial purpose, please contact Dr. Kurt Zhang at ke.zhang@UND.edu.